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学科主题: 口腔医学
题名:
The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro
作者: Ma, Ting1; Ge, Xi-Yuan2; Jia, Sheng-Nan1; Jiang, Xi1; Zhang, Yu1; Lin, Ye1
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra10701f
卷: 5, 期:99, 页:81378-81387
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: BONE-FORMATION ; BIOMATERIAL SURFACES ; IMPLANT SURFACES ; DENTAL IMPLANTS ; WEAR PARTICLES ; TNF-ALPHA ; DIFFERENTIATION ; OSSEOINTEGRATION ; HYDROPHILICITY ; MICROROUGHNESS
英文摘要:

Achieving fast and long-term osseointegration is one of the major goals in dental implant design. Physic-chemical surface modification is a key to osseointegration improvement. Two types of alkaline modifications, 1 M sodium bicarbonate and 0.05 M sodium hydroxide, were applied on the sand-blasting and acid etching (SLA) titanium surface. After the alkaline treatments, superhydrophilic SLA surfaces were produced. The mRNA expression level of IL-1 beta of Raw264.7 cells cultured on the sodium bicarbonate treated SLA surface was inhibited compared with SLA and sodium hydroxide treated surfaces, while MMP-9 expression on the sodium hydroxide treated SLA surface was increased with comparison to SLA and sodium bicarbonate treated surfaces. Cell adhesion of osteoblast-like MG63 cells on surfaces with alkaline treatments were moderately more pronounced than that on the SLA surface. With comparison to SLA surface, the proliferation of MG63 cells was decreased, while the alkaline phosphatase (ALP) activity was enhanced on the sodium bicarbonate treated SLA surface after 3 days. An increased mRNA expression level of integrin alpha(v) of MG63 cells were observed on the alkali treated surfaces compared with the SLA surface. Integrin beta 1, osteocalcin (OCN) and bone morphogenetic protein-2 (BMP-2) were enhanced on the sodium bicarbonate treated SLA surface when compared to the SLA surface. The results imply that the inflammation-related gene expression of macrophage cells is changed on sodium hydroxide and sodium bicarbonate treated SLA surfaces; the early adhesion of osteoblast-like cells is enhanced by both alkaline treatments, while the osteogenic differentiation is improved on sodium bicarbonate treated surface.

语种: 英语
所属项目编号: 2012CB933900
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000362436800059
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61057
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Oral Implantol, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Ma, Ting,Ge, Xi-Yuan,Jia, Sheng-Nan,et al. The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro[J]. RSC ADVANCES,2015,5(99):81378-81387.
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