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学科主题口腔医学
The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro
Ma, Ting1; Ge, Xi-Yuan2; Jia, Sheng-Nan1; Jiang, Xi1; Zhang, Yu1; Lin, Ye1
刊名RSC ADVANCES
2015
DOI10.1039/c5ra10701f
5期:99页:81378-81387
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program)
研究领域[WOS]Chemistry
关键词[WOS]BONE-FORMATION ; BIOMATERIAL SURFACES ; IMPLANT SURFACES ; DENTAL IMPLANTS ; WEAR PARTICLES ; TNF-ALPHA ; DIFFERENTIATION ; OSSEOINTEGRATION ; HYDROPHILICITY ; MICROROUGHNESS
英文摘要

Achieving fast and long-term osseointegration is one of the major goals in dental implant design. Physic-chemical surface modification is a key to osseointegration improvement. Two types of alkaline modifications, 1 M sodium bicarbonate and 0.05 M sodium hydroxide, were applied on the sand-blasting and acid etching (SLA) titanium surface. After the alkaline treatments, superhydrophilic SLA surfaces were produced. The mRNA expression level of IL-1 beta of Raw264.7 cells cultured on the sodium bicarbonate treated SLA surface was inhibited compared with SLA and sodium hydroxide treated surfaces, while MMP-9 expression on the sodium hydroxide treated SLA surface was increased with comparison to SLA and sodium bicarbonate treated surfaces. Cell adhesion of osteoblast-like MG63 cells on surfaces with alkaline treatments were moderately more pronounced than that on the SLA surface. With comparison to SLA surface, the proliferation of MG63 cells was decreased, while the alkaline phosphatase (ALP) activity was enhanced on the sodium bicarbonate treated SLA surface after 3 days. An increased mRNA expression level of integrin alpha(v) of MG63 cells were observed on the alkali treated surfaces compared with the SLA surface. Integrin beta 1, osteocalcin (OCN) and bone morphogenetic protein-2 (BMP-2) were enhanced on the sodium bicarbonate treated SLA surface when compared to the SLA surface. The results imply that the inflammation-related gene expression of macrophage cells is changed on sodium hydroxide and sodium bicarbonate treated SLA surfaces; the early adhesion of osteoblast-like cells is enhanced by both alkaline treatments, while the osteogenic differentiation is improved on sodium bicarbonate treated surface.

语种英语
所属项目编号2012CB933900
资助者National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program)
WOS记录号WOS:000362436800059
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61057
专题北京大学口腔医学院
作者单位1.Peking Univ, Sch Stomatol, Dept Oral Implantol, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Ma, Ting,Ge, Xi-Yuan,Jia, Sheng-Nan,et al. The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro[J]. RSC ADVANCES,2015,5(99):81378-81387.
APA Ma, Ting,Ge, Xi-Yuan,Jia, Sheng-Nan,Jiang, Xi,Zhang, Yu,&Lin, Ye.(2015).The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro.RSC ADVANCES,5(99),81378-81387.
MLA Ma, Ting,et al."The influence of titanium surfaces treated by alkalis on macrophage and osteoblast-like cell adhesion and gene expression in vitro".RSC ADVANCES 5.99(2015):81378-81387.
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