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学科主题: 药学
题名:
In vitro and in vivo antitumor activity of oridonin nanosuspension
作者: Lou, Haiyan2; Zhang, Xiumei2; Gao, Lei3; Feng, Feifei1; Wang, Juying2; Wei, Xinbing2; Yu, Zongqin1; Zhang, Dianrui1; Zhang, Qiang4
关键词: Oridonin ; Nanosuspension ; Antitumor ; Cytotoxicity
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2009-09-08
DOI: 10.1016/j.ijpharm.2009.06.022
卷: 379, 期:1, 页:181-186
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PARTICLE-SIZE REDUCTION ; POORLY SOLUBLE DRUGS ; CANCER-THERAPY ; NANOPARTICLES ; DELIVERY ; FORMULATION ; CELLS ; APOPTOSIS ; SYSTEMS
英文摘要:

The aim of the present study was to evaluate the antitumor activity of an oridonin (ORI) nanosuspension relative to ORI solution both in vitro and in vivo. ORI nanosuspension with a particle size of 897.2 +/- 14.2 nm was prepared by the high pressure homogenization method (HPH). MTT assay showed that ORI nanosuspension could significantly enhance the in vitro cytotoxicity against K562 cells compared to the ORI solution, the IC(50) value at 36 h was reduced from 12.85 mu mol/L for ORI solution to 8.11 mu mol/L for ORI nanosuspension. Flow cytometric analysis demonstrated that the ORI nanosuspension also induced a higher apoptotic rate in K562 cells compared to ORI solution. In vivo studies in a mouse model of sarcoma-180 solid tumors demonstrated significantly greater inhibition of tumor growth following treatment with ORI nanosuspension than ORI solution at the same dosage. The mice injected with ORI nanosuspension showed a higher reduction in tumor volume and tumor weight at the dose of 20 mg/kg compared to the ORI solution (P<0.01), with the tumor inhibition rate increased from 42.49% for ORI solution to 60.23% for the ORI nanosuspension. Taken together, these results suggest that the delivery of ORI in nanosuspension is a promising approach for the treatment of the tumor. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30672674 ; 2009CB930300
项目资助者: National Nature Science Foundation of China ; National Basic Research Program of China
WOS记录号: WOS:000269809600023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61059
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Sch Pharm, Dept Pharmaceut, Jinan 250012, Shandong Prov, Peoples R China
2.Shandong Univ, Sch Pharm, Dept Pharmacol, Jinan 250012, Peoples R China
3.First Affiliated Hosp Gen Hosp PLA, Dept Pharm, Beijing 100037, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Lou, Haiyan,Zhang, Xiumei,Gao, Lei,et al. In vitro and in vivo antitumor activity of oridonin nanosuspension[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2009,379(1):181-186.
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