学科主题临床医学
A novel CFTR mutation found in a Chinese patient with cystic fibrosis
Li, N; Pei, P; Bu, DF; He, B; Wang, GF
关键词cystic fibrosis transmembrane conductance regulator gene mutation
刊名CHINESE MEDICAL JOURNAL
2006-01-20
119期:2页:103-109
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]GENE ; IDENTIFICATION
英文摘要

Background Cystic fibrosis (CF) is rare in Chinese. We investigated the mutations in the gene of cystic fibrosis transmembrane conductance regulator (CFTR) in a Chinese CF patient and reviewed the clinical features, gene mutations in Chinese CF cases.

Methods Blood samples were collected from a previously reported CF girl and her parents. The 24 coding exons of CFTR of the proband were amplified and sequenced.

Results A Chinese girl of 16 years old was diagnosed as CF at the age of 14. She had recurrent productive cough with bronchiectasis in bilateral upper lobes, parasinusitis and otitis media, but without pancreatic involvement. Her sweat chloride was (108.9 +/- 3.3) mmol/L. A heterozygous novel missense mutation of 699 C -> A which results in the amino acid change of N189K was identified in exon 5. In addition, a heterozygous 3821-3823 delT mutation in exon 19 was found in CFTR. The mutation 699C -> A was inherited from her father, and the 3821-3823delT mutation was from her mother. Twenty patients with CF in Chinese reported from 1974 to 2004 were also reviewed. DelF508 mutation was not found in the nine cases whose CFTR mutations were analyzed.

Conclusions The CF proband carries two heterozygous mutations (699C -> A and 3821-3823delT) in CFTR. 699C -> A mutation is a novel mutation which is not reported previously. Review of reported Chinese cases suggests that the genotype of Chinese CF may be different from those of white cases. More studies are needed to understand the spectra of CFTR and clinical CF features in Chinese.

语种英语
WOS记录号WOS:000235055200003
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61063
专题北京大学第一临床医学院_呼吸和危重症医学科
作者单位1.Peking Univ First Hosp, Dept Pulm Med, Beijing 100034, Peoples R China
2.Peking Univ First Hosp, Cent Lab, Beijing 100034, Peoples R China
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GB/T 7714
Li, N,Pei, P,Bu, DF,et al. A novel CFTR mutation found in a Chinese patient with cystic fibrosis[J]. CHINESE MEDICAL JOURNAL,2006,119(2):103-109.
APA Li, N,Pei, P,Bu, DF,He, B,&Wang, GF.(2006).A novel CFTR mutation found in a Chinese patient with cystic fibrosis.CHINESE MEDICAL JOURNAL,119(2),103-109.
MLA Li, N,et al."A novel CFTR mutation found in a Chinese patient with cystic fibrosis".CHINESE MEDICAL JOURNAL 119.2(2006):103-109.
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