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学科主题: 精神卫生
题名:
An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population
作者: Fan, Hua2; Zhang, Fuquan1; Xu, Yong1,3; Huang, Xuezhu1; Sun, Gaoxiang1; Song, Yuqing4; Long, Haiyin2; Liu, Pozi1
关键词: Schizophrenia ; DRD2 ; rs6277
刊名: NEUROSCIENCE LETTERS
发表日期: 2010-06-21
DOI: 10.1016/j.neulet.2009.11.017
卷: 477, 期:2, 页:53-56
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DOPAMINE D2 RECEPTOR ; AVAILABILITY IN-VIVO ; C957T POLYMORPHISM ; WORKING-MEMORY ; METAANALYSIS ; PSYCHOSIS ; GENOTYPE ; VARIANT ; SHESIS ; RISK
英文摘要:

Dopamine signaling is strongly implicated in the etiology of schizophrenia (SZ). Because of the essential role dopamine D2 receptor (DRD2) in dopamine signaling, DRD2 gene has been regarded as one of the top candidate genes for SZ. However, the findings from linkage and association analyses on this gene are mixed and largely inconsistent across various studies. The aim of this study is to investigate the correlation of DRD2 gene variation and the risk for SZ in a Chinese Han population. Three SNPs (rs1801028, rs6275 and rs6277) of DRD2 gene were genotyped in a patient-control sample involving 421 SZ patients and 404 healthy controls. Our data indicated a nominally significant association of rs6277 with SZ, with T-allele being the risk allele (OR = 1.58, 95%CI = 1.03-2.43, P=0.034). This study suggests that rs6277 T-allele may play a role in the genetic vulnerability for SZ, supporting the involvement of DRD2 gene in SZ pathogenesis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30570430
项目资助者: National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000278941400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61065
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Tsinghua Univ, Yuquan Hosp, Dept Psychiat, Beijing 100049, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Dept Psychiat, Beijing 10088, Peoples R China
4.Shanxi Med Univ, Dept Psychiat, Hosp 1, Taiyuan 030001, Peoples R China

Recommended Citation:
Fan, Hua,Zhang, Fuquan,Xu, Yong,et al. An association study of DRD2 gene polymorphisms with schizophrenia in a Chinese Han population[J]. NEUROSCIENCE LETTERS,2010,477(2):53-56.
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