|Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia|
|Zhou, Fu-Chun1; Xiang, Yu-Tao1,2; Wang, Chuan-Yue1; Dickerson, Faith3; Au, Raymond W. C.2; Zhou, Jing-Jing1; Zhou, Yan1; Shum, David H. K.4,5; Chiu, Helen F. K.2; Man, David6; Lee, Edwin H. M.2; Yu, Xin7; Chan, Raymond C. K.8; Ungvari, Gabor S.9|
|关键词||First-episode schizophrenia Prospective memory Cognitive functions|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|关键词[WOS]||WORKING-MEMORY ; ACETYLCHOLINE-RECEPTORS ; RETROSPECTIVE-MEMORY ; UNTREATED PSYCHOSIS ; EXECUTIVE FUNCTION ; IMPAIRMENT ; HALOPERIDOL ; CLOZAPINE ; DEFICITS ; BRAIN|
Objective: The aim of this study was to examine prospective memory (PM) and its socio-demographic, clinical, and neurocognitive correlates in first episode schizophrenia (FES).
Methods: Fifty-one FES patients and 42 healthy controls formed the study sample. Time-and event-based PM (TBPM and EBPM) performance were measured with the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT). A battery of neuropsychological tests was also administered. Patients′ clinical symptoms were evaluated with the Positive and Negative Symptom Scale (PANSS).
Results: Patients performed significantly worse in both TBPM (8.7 +/- 5.3 vs. 14.8 +/- 3.5) and EBPM (11.3 +/- 4.7 vs. 15.7 +/- 2.7) than the controls. After controlling for age, gender, education level and neurocognitive test score, the difference in performance on the two types of PM tasks between patients and controls was no longer present. In multiple linear regression analyses, longer duration of untreated psychosis (DUP), lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the categories completed of the Wisconsin Card Sorting Test (WCST-CC) and higher score of the Color Trails Test-2 (CTT-2) contributed to poorer TBPM performance, while lower score of HVLT-R, higher score of the perseverative errors of the Wisconsin Card Sorting Test (WCST-PE) and longer DUP contributed to worse performance on EBPM.
Conclusions: Both subtypes of PM are impaired in first-episode schizophrenia suggesting that PM deficits are an integral part of the cognitive dysfunction in the disease process. (C) 2011 Elsevier B.V. All rights reserved.
|项目编号||81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2007BAI17B04 ; 2009AA022702|
|资助机构||National Natural Science Foundation of China ; Beijing Sciences and Technology Nova Program ; National Scientific and Technical Supporting Programs of China ; National High Technology Research and Development Program of China (863 Program)|
|作者单位||1.Stanley Res Program Sheppard Pratt, Baltimore, MD USA|
2.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
5.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
6.Griffith Univ, Griffith Hlth Inst, Brisbane, Qld 4111, Australia
7.Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Hong Kong, Peoples R China
8.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
9.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
|Zhou, Fu-Chun,Xiang, Yu-Tao,Wang, Chuan-Yue,et al. Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2012,135(1-3):34-39.|
|APA||Zhou, Fu-Chun.,Xiang, Yu-Tao.,Wang, Chuan-Yue.,Dickerson, Faith.,Au, Raymond W. C..,...&Ungvari, Gabor S..(2012).Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia.SCHIZOPHRENIA RESEARCH,135(1-3),34-39.|
|MLA||Zhou, Fu-Chun,et al."Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia".SCHIZOPHRENIA RESEARCH 135.1-3(2012):34-39.|