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Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia
Zhou, Fu-Chun1; Xiang, Yu-Tao1,2; Wang, Chuan-Yue1; Dickerson, Faith3; Au, Raymond W. C.2; Zhou, Jing-Jing1; Zhou, Yan1; Shum, David H. K.4,5; Chiu, Helen F. K.2; Man, David6; Lee, Edwin H. M.2; Yu, Xin7; Chan, Raymond C. K.8; Ungvari, Gabor S.9
关键词First-episode schizophrenia Prospective memory Cognitive functions
刊名SCHIZOPHRENIA RESEARCH
2012-03-01
DOI10.1016/j.schres.2011.12.001
135期:1-3页:34-39
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
资助者National Natural Science Foundation of China ; Beijing Sciences and Technology Nova Program ; National Scientific and Technical Supporting Programs of China ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China ; Beijing Sciences and Technology Nova Program ; National Scientific and Technical Supporting Programs of China ; National High Technology Research and Development Program of China (863 Program)
研究领域[WOS]Psychiatry
关键词[WOS]WORKING-MEMORY ; ACETYLCHOLINE-RECEPTORS ; RETROSPECTIVE-MEMORY ; UNTREATED PSYCHOSIS ; EXECUTIVE FUNCTION ; IMPAIRMENT ; HALOPERIDOL ; CLOZAPINE ; DEFICITS ; BRAIN
英文摘要

Objective: The aim of this study was to examine prospective memory (PM) and its socio-demographic, clinical, and neurocognitive correlates in first episode schizophrenia (FES).

Methods: Fifty-one FES patients and 42 healthy controls formed the study sample. Time-and event-based PM (TBPM and EBPM) performance were measured with the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT). A battery of neuropsychological tests was also administered. Patients′ clinical symptoms were evaluated with the Positive and Negative Symptom Scale (PANSS).

Results: Patients performed significantly worse in both TBPM (8.7 +/- 5.3 vs. 14.8 +/- 3.5) and EBPM (11.3 +/- 4.7 vs. 15.7 +/- 2.7) than the controls. After controlling for age, gender, education level and neurocognitive test score, the difference in performance on the two types of PM tasks between patients and controls was no longer present. In multiple linear regression analyses, longer duration of untreated psychosis (DUP), lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the categories completed of the Wisconsin Card Sorting Test (WCST-CC) and higher score of the Color Trails Test-2 (CTT-2) contributed to poorer TBPM performance, while lower score of HVLT-R, higher score of the perseverative errors of the Wisconsin Card Sorting Test (WCST-PE) and longer DUP contributed to worse performance on EBPM.

Conclusions: Both subtypes of PM are impaired in first-episode schizophrenia suggesting that PM deficits are an integral part of the cognitive dysfunction in the disease process. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
所属项目编号81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2007BAI17B04 ; 2009AA022702
资助者National Natural Science Foundation of China ; Beijing Sciences and Technology Nova Program ; National Scientific and Technical Supporting Programs of China ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China ; Beijing Sciences and Technology Nova Program ; National Scientific and Technical Supporting Programs of China ; National High Technology Research and Development Program of China (863 Program)
WOS记录号WOS:000300940000006
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61066
专题北京大学精神卫生研究所
作者单位1.Stanley Res Program Sheppard Pratt, Baltimore, MD USA
2.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
5.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
6.Griffith Univ, Griffith Hlth Inst, Brisbane, Qld 4111, Australia
7.Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Hong Kong, Peoples R China
8.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
9.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
推荐引用方式
GB/T 7714
Zhou, Fu-Chun,Xiang, Yu-Tao,Wang, Chuan-Yue,et al. Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2012,135(1-3):34-39.
APA Zhou, Fu-Chun.,Xiang, Yu-Tao.,Wang, Chuan-Yue.,Dickerson, Faith.,Au, Raymond W. C..,...&Ungvari, Gabor S..(2012).Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia.SCHIZOPHRENIA RESEARCH,135(1-3),34-39.
MLA Zhou, Fu-Chun,et al."Characteristics and clinical correlates of prospective memory performance in first-episode schizophrenia".SCHIZOPHRENIA RESEARCH 135.1-3(2012):34-39.
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