IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Comparison of the major malformation rate of children conceived from cryopreserved embryos and fresh embryos
Li Hong-zhen; Qiao Jie; Chi Hong-bin; Chen Xin-na; Liu Ping; Ma Cai-hong
关键词congenital malformation fertilization in vitro sperm injections intracytoplasmic frozen-thawed embryo transfer
刊名CHINESE MEDICAL JOURNAL
2010-07-20
DOI10.3760/cma.j.issn.0366-6999.2010.14.012
123期:14页:1893-1897
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]IN-VITRO FERTILIZATION ; INTRACYTOPLASMIC SPERM INJECTION ; ASSISTED-REPRODUCTIVE-TECHNOLOGY ; BIRTH-DEFECTS ; CONGENITAL-MALFORMATIONS ; UNITED-STATES ; IVF-METHODS ; ICSI ; PREGNANCIES ; BORN
英文摘要

Background Cryopreserved embryo transfer has become indispensable in reproductive technology. More and more children are conceived from frozen-thawed embryo transfer (FET). The risk of birth defects associated with frozen-thawed embryo transfer has been evaluated and conflict results are obtained. The aim of this study was to compare the rate of major malformations in children conceived from cryopreserved embryos with that of children from fresh embryos.

Methods A retrospective analysis was performed on children conceived from frozen-thawed embryos and fresh embryos between January 2005 and December 2008 at the Reproduction Center of the Third Hospital, Peking University. The major malformation rates were compared between two groups for all children, as well as singletons or twins, separately. The frequencies of different subtypes of malformations classified according to different organ system were also compared.

Results Thirty-four of 3125 children from cryopreserved embryos had a major malformation. The malformation rate was 1.09%, which was comparable to that for children after fresh embryos transfer (1.53%(55/3604), OR: 0.71, 95% CI; 0.46-1.09). The malformation rate was also similar when the analysis was limited to children from cryopreserved embryos resulted from in vitro fertilization (IVF)(1.39%)and fresh IVF(1.3%). However, children from cryopreserved embryos resulted from intracytoplasmic sperm injections (ICSI) had much lower malformation rate than from fresh ICSI(0.63% vs.1.83%, OR: 0.34, 95% CI: 0.16-0.75). No difference was found in the incidence of major malformations in singletons from cryo ICSI (0.73%) and fresh ICSI(1.9%), or from cryo IVF(1.49%) and fresh IVF(1.67%). Similar malformation rate was found in multiples from cryo ICSI(0.52%) and fresh ICSI(1.76%), or cryo IVF(1.30%) and fresh IVF(0.90%). The distribution and risk of the subtype of malformations, such as cardiovascular, gastrointestinal, neural tube, urogenital, musculoskeletal and facial abnormalities was not different between the cryo group and fresh group.

Conclusions The major malformation rate is similar between fetuses/children conceived from cryopreserved embryos and those from fresh embryos. Large prospective and long-term follow-up studies are needed to get exact results concerning the birth defects of the children born after cryopreserved embryos. Chin Med J 2010;123(14):1893-1897

语种英语
WOS记录号WOS:000280433700012
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61069
Collection北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynecol, Med Ctr Human Reprod, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li Hong-zhen,Qiao Jie,Chi Hong-bin,et al. Comparison of the major malformation rate of children conceived from cryopreserved embryos and fresh embryos[J]. CHINESE MEDICAL JOURNAL,2010,123(14):1893-1897.
APA Li Hong-zhen,Qiao Jie,Chi Hong-bin,Chen Xin-na,Liu Ping,&Ma Cai-hong.(2010).Comparison of the major malformation rate of children conceived from cryopreserved embryos and fresh embryos.CHINESE MEDICAL JOURNAL,123(14),1893-1897.
MLA Li Hong-zhen,et al."Comparison of the major malformation rate of children conceived from cryopreserved embryos and fresh embryos".CHINESE MEDICAL JOURNAL 123.14(2010):1893-1897.
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