IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study
Fan, Feng-Mei1,2; Tan, Shu-Ping1; Yang, Fu-De1; Tan, Yun-Long1; Zhao, Yan-Li1; Chen, Nan1; Li, Bin-Bin1; Song, Chong-Sheng1; Wang, Yun-Hui1; Jin, Zhen3; Zhou, Dong-Feng4; Milham, Michael P.5,6; Zou, Yi-Zhuang1; Zuo, Xi-Nian2
关键词schizophrenia emotion regulation ventral medial prefrontal cortex functional connectivity resting state functional MRI
刊名NEUROSCIENCE BULLETIN
2013-02-01
DOI10.1007/s12264-013-1300-8
29期:1页:59-74
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者Beijing Municipal Science &amp ; Technology Commission ; Beijing Natural Science Foundation ; Fund for Capital Medical Development and Research ; National Natural Science Foundation of China ; Startup Foundation for Distinguished Research Professors of the Institute for Psychology ; Fund for Outstanding Talents in Beijing ; Beijing Municipal Science &amp ; Technology Commission ; Beijing Natural Science Foundation ; Fund for Capital Medical Development and Research ; National Natural Science Foundation of China ; Startup Foundation for Distinguished Research Professors of the Institute for Psychology ; Fund for Outstanding Talents in Beijing
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]TASK-INDUCED DEACTIVATION ; CONSENSUS COGNITIVE BATTERY ; LOW-FREQUENCY FLUCTUATIONS ; MAGNETIC-RESONANCE IMAGES ; BRAINS DEFAULT NETWORK ; RESTING-STATE ; SOCIAL COGNITION ; DECISION-MAKING ; AUDITORY HALLUCINATIONS ; CEREBRAL-CORTEX
英文摘要

People with schizophrenia exhibit impaired social cognitive functions, particularly emotion regulation. Abnormal activations of the ventral medial prefrontal cortex (vMPFC) during emotional tasks have been demonstrated in schizophrenia, suggesting its important role in emotion processing in patients. We used the resting-state functional connectivity approach, setting a functionally relevant region, the vMPFC, as a seed region to examine the intrinsic functional interactions and communication between the vMPFC and other brain regions in schizophrenic patients. We found hypo-connectivity between the vMPFC and the medial frontal cortex, right middle temporal lobe (MTL), right hippocampus, parahippocampal cortex (PHC) and amygdala. Further, there was a decreased strength of the negative connectivity (or anticorrelation) between the vMPFC and the bilateral dorsal lateral prefrontal cortex (DLPFC) and pre-supplementary motor areas. Among these connectivity alterations, reduced vMPFC-DLPFC connectivity was positively correlated with positive symptoms on the Positive and Negative Syndrome Scale, while vMPFC-right MTL/PHC/amygdala functional connectivity was positively correlated with the performance of emotional regulation in patients. These findings imply that communication and coordination throughout the brain networks are disrupted in schizophrenia. The emotional correlates of vMPFC connectivity suggest a role of the hypo-connectivity between these regions in the neuropathology of abnormal social cognition in chronic schizophrenia.

语种英语
所属项目编号D0906001040191 ; D101107047810005 ; D101100050010051 ; 7102086 ; 2007-3059 ; 81171409 ; Y0CX492S03 ; 2012D003034000003
资助者Beijing Municipal Science &amp ; Technology Commission ; Beijing Natural Science Foundation ; Fund for Capital Medical Development and Research ; National Natural Science Foundation of China ; Startup Foundation for Distinguished Research Professors of the Institute for Psychology ; Fund for Outstanding Talents in Beijing ; Beijing Municipal Science &amp ; Technology Commission ; Beijing Natural Science Foundation ; Fund for Capital Medical Development and Research ; National Natural Science Foundation of China ; Startup Foundation for Distinguished Research Professors of the Institute for Psychology ; Fund for Outstanding Talents in Beijing
WOS记录号WOS:000314298300009
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61070
Collection北京大学精神卫生研究所
作者单位1.Beijing Huilongguan Hosp, Psychiat Res Ctr, Beijing 100096, Peoples R China
2.Chinese Acad Sci, Lab Funct Connectome & Dev, Magnet Resonance Imaging Res Ctr, Key Lab Behav Sci,Inst Psychol, Beijing 100101, Peoples R China
3.306th Hosp PLA, Magnet Resonance Imaging Unit, Beijing 100091, Peoples R China
4.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
5.Child Mind Inst, Ctr Dev Brain, New York, NY 10022 USA
6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
Recommended Citation
GB/T 7714
Fan, Feng-Mei,Tan, Shu-Ping,Yang, Fu-De,et al. Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study[J]. NEUROSCIENCE BULLETIN,2013,29(1):59-74.
APA Fan, Feng-Mei.,Tan, Shu-Ping.,Yang, Fu-De.,Tan, Yun-Long.,Zhao, Yan-Li.,...&Zuo, Xi-Nian.(2013).Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study.NEUROSCIENCE BULLETIN,29(1),59-74.
MLA Fan, Feng-Mei,et al."Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study".NEUROSCIENCE BULLETIN 29.1(2013):59-74.
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