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学科主题: 临床医学
题名:
Extralevator abdominoperineal excision for low rectal cancer: a systematic review and meta-analysis of the short-term outcome
作者: Zhou, X.; Sun, T.; Xie, H.; Zhang, Y.; Zeng, H.; Fu, W.
关键词: Extralevator abdominoperineal excision ; circumferential resection margin ; intra-operative bowel perforation ; perineal wound complications ; rectal cancer
刊名: COLORECTAL DISEASE
发表日期: 2015-06-01
DOI: 10.1111/codi.12921
卷: 17, 期:6, 页:474-481
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: TRANSABDOMINAL LEVATOR TRANSECTION ; TOTAL MESORECTAL EXCISION ; PELVIC ANATOMY ; SINGLE-CENTER ; RESECTION ; STANDARD ; RECONSTRUCTION ; PERINEAL ; ELAPE ; SUPERIORITY
英文摘要:

AimThe superiority of extralevator abdominoperineal excision (ELAPE) over conventional abdominoperineal excision (APE) remains controversial, despite the publication of many studies on this issue. The aim of this meta-analysis was to provide a clear, evidence-based comparison of the two procedures.

MethodA systematic review and meta-analysis was conducted through a comprehensive search of the PubMed, EMBASE/Medline and Cochrane Central Library databases for all studies comparing ELAPE with conventional APE for low rectal cancer. Pooled data on circumferential resection margin (CRM) positivity, intra-operative bowel perforation, perineal wound complications and local recurrence were analysed.

ResultsSeven studies, involving a total of 2672 patients, were included. Analysis of the pooled data did not reveal a significant difference between the two operations regarding CRM positivity [risk ratio (RR)=0.79, 95% CI: 0.40-1.57; P=0.50, I-2=86%] and perineal wound complications (RR=0.91, 95% CI: 0.71-1.16; P=0.44, I-2=49%), and showed a borderline reduced risk of intra-operative bowel perforation for ELAPE, but still did not reveal a significant difference between the two groups (RR=0.61, 95% CI: 0.37-1.00; P=0.05, I-2=58%).

ConclusionThe current evidence does not indicate a statistically significant superiority of ELAPE over conventional APE in terms of CRM positivity and intra-operative bowel perforation.

语种: 英语
WOS记录号: WOS:000354813200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61071
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, X.,Sun, T.,Xie, H.,et al. Extralevator abdominoperineal excision for low rectal cancer: a systematic review and meta-analysis of the short-term outcome[J]. COLORECTAL DISEASE,2015,17(6):474-481.
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