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学科主题: 临床医学
题名:
Off-label prescriptions for adult neurological patients: a pilot survey in China
作者: Yi, Zhan-Miao1; Zhai, Suo-Di1; Huang, Sen2; Wang, Tian-Sheng3; Liu, Fang1
关键词: China ; Neurological patients ; Observational ; Off-label prescribing ; Retrospective ; Supporting evidence
刊名: INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
发表日期: 2012-02-01
DOI: 10.1007/s11096-011-9590-2
卷: 34, 期:1, 页:81-87
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PLATELET-AGGREGATION ; CHILDREN
英文摘要:

Background Data concerning the extent of off-label prescriptions for adult neurological patients are limited, and the method of assessing supporting evidence in previous studies has some limitations. Objective To improve the method of assessing supporting evidence, determine the status of off-label prescriptions for adult neurological patients, and evaluate the varying levels of supporting evidence. Setting Single, 1,264-bed, tertiary care university hospital in Beijing, China. Method This was a pilot retrospective observational study for adult neurological patients during the period of March 22nd-28th, 2010. Off-label prescriptions were defined according to package inserts. The DRUGDEX system was used to evaluate supporting evidence initially; when information was not available, PubMed/CBM was searched and the grading system proposed by Oxford Centre for Evidence-Based Medicine (OCEBM) was used for categorizing supporting evidence alternatively. Main outcome measure Types, main therapeutic classes and main neurological diseases involved, evidence and recommendation strengths of off-label prescriptions. Results A total of 418 off-label prescriptions were identified from 3,187 prescriptions for 966 patients, 193 from 759 inpatient (25.4%) and 225 from 2,428 outpatient care (9.3%). Most off-label prescriptions were related to unapproved indications. These off-label prescriptions mainly included drugs labeled for nervous system diseases, cerebrovascular diseases, anemia and ophthalmic conditions; and the medication orders were mostly for cerebrovascular diseases. A total of 155 (37.1%) were initially searched and evaluated in the DRUGDEX system; the remaining 263 (62.9%) prescriptions were found in PubMed/CBM search and evaluated by the OCEBM grading system. Sixty-six (34.2%) off-label prescriptions from inpatients and 103 (45.8%) from outpatients were categorized as Class III or Grade D recommendations. Conclusions The improved method provided a supplementary way to study off-label uses. Off-label prescriptions for adult neurological patients mainly concerned unapproved indications, nervous system agents and cerebrovascular diseases, and many of them had inferior level of evidence.

语种: 英语
WOS记录号: WOS:000299329300013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61073
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ, Dept Pharm, Hosp 3, Beijing 100871, Peoples R China
2.Peking Univ, Dept Hlth Policy & Management, Sch Publ Hlth, Beijing 100871, Peoples R China
3.Peking Univ, Dept Pharm Adm & Clin Pharm, Sch Pharmaceut Sci, Beijing 100871, Peoples R China

Recommended Citation:
Yi, Zhan-Miao,Zhai, Suo-Di,Huang, Sen,et al. Off-label prescriptions for adult neurological patients: a pilot survey in China[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACY,2012,34(1):81-87.
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