IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Risk Factors for Severe Illness with 2009 Pandemic Influenza A (H1N1) Virus Infection in China
Yu, Hongjie1; Feng, Zijian1; Uyeki, Timothy M.5; Liao, Qiaohong1; Zhou, Lei1; Feng, Luzhao1; Ye, Min1; Xiang, Nijuan1; Huai, Yang1; Yuan, Yuan3; Jiang, Hui1; Zheng, Yingdong4; Gargiullo, Paul5; Peng, Zhibin1; Feng, Yunxia1; Zheng, Jiandong1; Xu, Cuiling2; Zhang, Yanping2; Shu, Yuelong2; Gao, Zhancheng3; Yang, Weizhong1; Wang, Yu1
刊名CLINICAL INFECTIOUS DISEASES
2011-02-01
DOI10.1093/cid/ciq144
52期:4页:457-465
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Microbiology
资助者Ministry of Health, China ; US National Institutes of Health ; China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases ; Ministry of Health, China ; US National Institutes of Health ; China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases
研究领域[WOS]Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]CRITICALLY-ILL PATIENTS ; PREGNANT-WOMEN ; A(H1N1) INFECTION ; UNITED-STATES ; HOSPITALIZATION ; PREVALENCE ; CALIFORNIA ; OUTCOMES ; CANADA ; MEXICO
英文摘要

Background. Data on risk factors for severe outcomes from 2009 pandemic influenza A (H1N1) virus infection are limited outside of developed countries.

Methods. We reviewed medical charts to collect data from patients hospitalized with laboratory-confirmed 2009 H1N1 infection who were identified across China during the period from September 2009 through February 2010, and we analyzed potential risk factors associated with severe illness (defined as illness requiring intensive care unit admission or resulting in death).

Results. Among 9966 case patients, the prevalence of chronic medical conditions (33% vs 14%), pregnancy (15% vs 7%), or obesity (19% vs 14%) was significantly higher in those patients with severe illness than it was in those with less severe disease. In multivariable analyses, among nonpregnant case patients aged >= 2 years, having a chronic medical condition significantly increased the risk of severe outcome among all age groups, and obesity was a risk factor among those < 60 years of age. The risk of severe illness among pregnant case patients was significantly higher for those in the second and third trimesters. The risk of severe illness was increased when oseltamivir treatment was initiated >= 5 days after illness onset (odds ratio, 1.42; 95% confidence interval, 1.20-1.67). For persons < 60 years of age, the prevalence of obesity among case patients with severe illness was significantly greater than it was among those without severe illness or among the general population.

Conclusions. Risk factors for severe 2009 H1N1 illness in China were similar to those observed in developed countries, but there was a lower prevalence of chronic medical conditions and a lower prevalence of obesity. Obesity was a risk factor among case patients < 60 years of age. Early initiation of oseltamivir treatment was most beneficial, and there was an increased risk of severe disease when treatment was started >= 5 days after illness onset.

语种英语
所属项目编号U19 AI51915
资助者Ministry of Health, China ; US National Institutes of Health ; China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases ; Ministry of Health, China ; US National Institutes of Health ; China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases
WOS记录号WOS:000286677800009
引用统计
被引频次:91[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61078
专题北京大学第二临床医学院
作者单位1.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Off Dis Control & Emergency Response, Beijing 102206, Peoples R China
2.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China
3.Peking Univ Hlth Sci Ctr, Peking Univ Peoples Hosp, Beijing, Peoples R China
4.Peking Univ Hlth Sci Ctr, Sch Publ Hlth, Beijing, Peoples R China
5.Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA
推荐引用方式
GB/T 7714
Yu, Hongjie,Feng, Zijian,Uyeki, Timothy M.,et al. Risk Factors for Severe Illness with 2009 Pandemic Influenza A (H1N1) Virus Infection in China[J]. CLINICAL INFECTIOUS DISEASES,2011,52(4):457-465.
APA Yu, Hongjie.,Feng, Zijian.,Uyeki, Timothy M..,Liao, Qiaohong.,Zhou, Lei.,...&Wang, Yu.(2011).Risk Factors for Severe Illness with 2009 Pandemic Influenza A (H1N1) Virus Infection in China.CLINICAL INFECTIOUS DISEASES,52(4),457-465.
MLA Yu, Hongjie,et al."Risk Factors for Severe Illness with 2009 Pandemic Influenza A (H1N1) Virus Infection in China".CLINICAL INFECTIOUS DISEASES 52.4(2011):457-465.
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