IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Association of carotid atherosclerotic plaque features with acute ischemic stroke: A magnetic resonance imaging study
Zhao, Huilin1; Zhao, Xihai2; Liu, Xiaosheng1; Cao, Ye1; Hippe, Daniel S.3; Sun, Jie3; Li, Feiyu4; Xu, Jianrong1; Yuan, Chun2,3
关键词Atherosclerosis Carotid arteries Magnetic resonance imaging Plaque Stenosis Stroke
刊名EUROPEAN JOURNAL OF RADIOLOGY
2013-09-01
DOI10.1016/j.ejrad.2013.04.014
82期:9页:E465-E470
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]IN-VIVO ; STENOSIS ; LESIONS ; ENDARTERECTOMY ; PREVALENCE ; PREDICTION ; RECOVERY ; EVENTS ; SCALE ; MRI
英文摘要

Background and purpose: It remains unclear whether direct vessel wall imaging can identify carotid high-risk lesions in symptomatic subjects and whether carotid plaque characteristics are more effective indicators for cerebral infarct severity than stenosis. This study sought to determine the associations of carotid plaque characteristics by MR imaging with stenosis and acute cerebral infarct (ACI) sizes on diffusion weighted imaging (DWI).

Materials and methods: One hundred and fourteen symptomatic patients underwent carotid and brain MRI. ACI volume was determined from symptomatic internal carotid artery territory on DWI images. Ipsilateral carotid plaque morphological and compositional characteristics, and stenosis were also determined. The relationships between carotid plaque characteristics, stenosis and ACIs size were then evaluated.

Results: In carotid arteries with 30-49% stenosis, 86.7% and 26.7% were found to have lipid-rich necrotic core (LRNC) and intraplaque hemorrhage, respectively. Furthermore, 45.8% of carotid arteries with 0-29% stenosis developed LRNCs. Carotid morphological measurements, such as % wall volume, and the LRNC size were significantly associated with ipsilateral ACIs volume before and after adjustment for significant demographic factors (age and LDL) or stenosis in patients with carotid plaque (all p < 0.05).

Conclusions: A substantial number of high-risk plaques characterized by vessel wall imaging exist in carotid arteries with lower grade stenosis. In addition, carotid plaque characteristics, particularly the % wall volume and LRNC size, are independently associated with cerebral infarction as measured by DWI lesions. Our findings indicate that characterizing atherosclerotic plaque by MR vessel wall imaging might be useful for stratification of plaque risk and infarction severity. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000323935200012
项目编号S30203 ; 81271536 ; 81271575 ; HL 56874 ; HL 103609
资助机构Shanghai Leading Academic Discipline Project ; Philips Healthcare ; National Natural Science Foundation of China ; NIH
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61082
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
作者单位1.Shanghai Jiao Tong Univ, Dept Radiol, Renji Hosp, Sch Med, Shanghai 200127, Peoples R China
2.Tsinghua Univ, Sch Med, Dept Biomed Engn, Ctr Biomed Imaging Res, Beijing 100084, Peoples R China
3.Univ Washington, Dept Radiol, Seattle, WA 98109 USA
4.Peking Univ, Dept Radiol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Huilin,Zhao, Xihai,Liu, Xiaosheng,et al. Association of carotid atherosclerotic plaque features with acute ischemic stroke: A magnetic resonance imaging study[J]. EUROPEAN JOURNAL OF RADIOLOGY,2013,82(9):E465-E470.
APA Zhao, Huilin.,Zhao, Xihai.,Liu, Xiaosheng.,Cao, Ye.,Hippe, Daniel S..,...&Yuan, Chun.(2013).Association of carotid atherosclerotic plaque features with acute ischemic stroke: A magnetic resonance imaging study.EUROPEAN JOURNAL OF RADIOLOGY,82(9),E465-E470.
MLA Zhao, Huilin,et al."Association of carotid atherosclerotic plaque features with acute ischemic stroke: A magnetic resonance imaging study".EUROPEAN JOURNAL OF RADIOLOGY 82.9(2013):E465-E470.
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