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学科主题: 口腔医学
题名:
The hidden treasure in apical papilla: The potential role in pulp/dentin regeneration and bioroot engineering
作者: Huang, George T. -J.1; Sonoyama, Wataru; Liu, Yi3,4; Liu, He6; Wang, Songlin3,4; Shi, Songtao2
关键词: apexogenesis ; apical papilla ; bioroot engineering ; dental pulp stem cells ; immature teeth ; periodontal ligament stem cells ; pulp regeneration ; stem cells from human exfoliated deciduous teeth ; stem cells from the apical papilla
刊名: JOURNAL OF ENDODONTICS
发表日期: 2008-06-01
DOI: 10.1016/j.joen.2008.03.001
卷: 34, 期:6, 页:645-651
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: MESENCHYMAL STEM-CELLS ; GROWTH-FACTOR DELIVERY ; AVULSED PERMANENT INCISORS ; CELLULITIS SYNDROME-V ; IMMATURE DOG TEETH ; DENTAL-PULP CELLS ; IN-VITRO ; TOOTH REGENERATION ; POLYMER SCAFFOLDS ; INFECTION CONTROL
英文摘要:

Some clinical case reports have shown that immature permanent teeth with periradicular periodontitis or abscess can undergo apexogenesis after conservative endodontic treatment. A call for a paradigm shift and new protocol for the clinical management of these cases has been brought to attention. Concomitantly, a new population of mesenchymal stem cells residing in the apical papilla of permanent immature teeth recently has been discovered and was termed stem cells from the apical papilla (SCAP). These stem cells appear to be the source of odontoblasts that are responsible for the formation of root dentin. Conservation of these stem cells when treating immature teeth may allow continuous formation of the root to completion. This article reviews current findings on the isolation and characterization of these stem cells. The potential role of these stem cells in the following respects will be discussed: (1) their contribution in continued root maturation in endodontically treated immature teeth with periradicular periodontitis or abscess and (2) their potential utilization for pulp/dentin regeneration and bioroot engineering.

语种: 英语
WOS记录号: WOS:000256454500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61085
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China
2.Univ Maryland, Coll Dent Surg, Sch Dent, Dept Endodont Prothodont & Operat Dent, Baltimore, MD 21201 USA
3.Univ So Calif, Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90089 USA
4.Capital Med Univ, Sch Stomatol, Salivary Gland Dis Ctr, Beijing, Peoples R China
5.Capital Med Univ, Sch Stomatol, Mol Lab Gene Therapy, Beijing, Peoples R China
6.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral & Maxillofacial Rehabil, Okayama, Japan

Recommended Citation:
Huang, George T. -J.,Sonoyama, Wataru,Liu, Yi,et al. The hidden treasure in apical papilla: The potential role in pulp/dentin regeneration and bioroot engineering[J]. JOURNAL OF ENDODONTICS,2008,34(6):645-651.
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