|Hand, foot, and mouth disease in China, 2008-12: an epidemiological study|
|Xing, Weijia1; Liao, Qiaohong1; Viboud, Cecile2; Zhang, Jing1; Sun, Junling1; Wu, Joseph T.3; Chang, Zhaorui1; Liu, Fengfeng1; Fang, Vicky J.3; Zheng, Yingdong4; Cowling, Benjamin J.3; Varma, Jay K.5; Farrar, Jeremy J.6,7,8,9; Leung, Gabriel M.3; Yu, Hongjie1|
|刊名||LANCET INFECTIOUS DISEASES|
|WOS标题词||Science & Technology|
|关键词[WOS]||ENTEROVIRUS 71 INFECTION ; COXSACKIEVIRUS A16 ; CHILDREN ; OUTBREAK ; TAIWAN ; SEROEPIDEMIOLOGY ; TEMPERATURE ; EMERGENCE ; SINGAPORE ; SHANGHAI|
Background Hand, foot, and mouth disease is a common childhood illness caused by enteroviruses. Increasingly, the disease has a substantial burden throughout east and southeast Asia. To better inform vaccine and other interventions, we characterised the epidemiology of hand, foot, and mouth disease in China on the basis of enhanced surveillance.
Methods We extracted epidemiological, clinical, and laboratory data from cases of hand, foot, and mouth disease reported to the Chinese Center for Disease Control and Prevention between Jan 1, 2008, and Dec 31, 2012. We then compiled climatic, geographical, and demographic information. All analyses were stratified by age, disease severity, laboratory confirmation status, and enterovirus serotype.
Findings The surveillance registry included 7 200 092 probable cases of hand, foot, and mouth disease (annual incidence, 1.2 per 1000 person-years from 2010-12), of which 267 942 (3.7%) were laboratory confirmed and 2457 (0.03%) were fatal. Incidence and mortality were highest in children aged 12-23 months (38.2 cases per 1000 person-years and 1.5 deaths per 100 000 person-years in 2012). Median duration from onset to diagnosis was 1.5 days (IQR 0.5-2.5) and median duration from onset to death was 3.5 days (2.5-4.5). The absolute number of patients with cardiopulmonary or neurological complications was 82 486 (case-severity rate 1.1%), and 2457 of 82486 patients with severe disease died (fatality rate 3.0%); 1617 of 1737 laboratory confirmed deaths (93%) were associated with enterovirus 71. Every year in June, hand, foot, and mouth disease peaked in north China, whereas southern China had semiannual outbreaks in May and September October. Geographical differences in seasonal patterns were weakly associated with climate and demographic factors (variance explained 8-23% and 3-19%, respectively).
Interpretation This is the largest population-based study up to now of the epidemiology of hand, foot, and mouth disease. Future mitigation policies should take into account the heterogeneities of disease burden identified. Additional epidemiological and serological studies are warranted to elucidate the dynamics and immunity patterns of local hand, foot, and mouth disease and to optimise interventions.
|资助机构||China-US Collaborative Program on Emerging and Re-emerging Infectious Diseases ; Li Ka Shing Oxford Global Health Programme ; Welkome Trust, Harvard Center for Communicable Disease Dynamics, and Health and Medical Research Fund, Government of Hong Kong Special Administrative Region ; WHO|
|作者单位||1.Li Ka Shing Oxford Global Hlth Programme & Wellco, Oxford, England|
2.Chinese Ctr Dis Control & Prevent, Key Lab Surveillance & Early Warning Infect Dis, Div Infect Dis, Beijing, Peoples R China
3.NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA
4.Univ Hong Kong, Sch Publ Hlth, Div Epidemiol & Biostatist, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China
5.Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100871, Peoples R China
6.New York City Dept Hlth & Mental Hyg, New York, NY USA
7.Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programmes, Ho Chi Minh City, Vietnam
8.Univ Oxford, Churchill Hosp, Int Severe Acute Resp & Emerging Infect Consortiu, Ctr Trop Med, Oxford, England
9.Natl Univ Singapore, Dept Med, Singapore 117548, Singapore
|Xing, Weijia,Liao, Qiaohong,Viboud, Cecile,et al. Hand, foot, and mouth disease in China, 2008-12: an epidemiological study[J]. LANCET INFECTIOUS DISEASES,2014,14(4):308-318.|
|APA||Xing, Weijia.,Liao, Qiaohong.,Viboud, Cecile.,Zhang, Jing.,Sun, Junling.,...&Yu, Hongjie.(2014).Hand, foot, and mouth disease in China, 2008-12: an epidemiological study.LANCET INFECTIOUS DISEASES,14(4),308-318.|
|MLA||Xing, Weijia,et al."Hand, foot, and mouth disease in China, 2008-12: an epidemiological study".LANCET INFECTIOUS DISEASES 14.4(2014):308-318.|