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学科主题: 基础医学
题名:
C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4
作者: Zhang, Yan; Tian, Linjie; Zheng, Yi; Qi, Hui; Guo, Changyuan; Sun, Qianying; Xu, Enquan; Zhang, Yingmei; Ma, Dalong; Wang, Ying1
关键词: CKLF1 ; Peptide ; CXCR4 ; CCR4 ; Desensitization ; PKC
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2011-06-03
DOI: 10.1016/j.bbrc.2011.05.047
卷: 409, 期:2, 页:356-361
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ACTIVATION ; TRAFFICKING ; CHEMOTAXIS ; EXPRESSION ; CYTOKINE ; LIGANDS ; ASTHMA ; CKLF1 ; SDF-1
英文摘要:

CKLF1, a human cytokine that is a functional ligand for CCR4, is upregulated in various inflammation and autoimmune diseases. CKLF1 contains at least two secreted forms, the C-terminal peptides C19 and C27. Chemically synthesized C19 and C27 can interact with CCR4 and attenuate allergic inflammation. In this study, we found C19 and C27 could inhibit SDF-1-induced CXCR4-mediated chemotaxis and promote CXCR4 internalization. The inhibitory effect was due to desensitization of CXCR4, which was mediated by CCR4. Further experiments confirmed that CXCR4 desensitization required activation of PI3K/PKC pathway. Altogether our data elucidate the mechanism of C19- and C27-induced CXCR4 desensitization. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2006AA02A305 ; 2009ZX09103-724 ; 30872292 ; 90813025
项目资助者: National High-Tech Research and Development Program of China ; National Key New Drug Creation Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000291779100036
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61100
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Yan,Tian, Linjie,Zheng, Yi,et al. C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,409(2):356-361.
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