学科主题基础医学
C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4
Zhang, Yan; Tian, Linjie; Zheng, Yi; Qi, Hui; Guo, Changyuan; Sun, Qianying; Xu, Enquan; Zhang, Yingmei; Ma, Dalong; Wang, Ying1
关键词CKLF1 Peptide CXCR4 CCR4 Desensitization PKC
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2011-06-03
DOI10.1016/j.bbrc.2011.05.047
409期:2页:356-361
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ACTIVATION ; TRAFFICKING ; CHEMOTAXIS ; EXPRESSION ; CYTOKINE ; LIGANDS ; ASTHMA ; CKLF1 ; SDF-1
英文摘要

CKLF1, a human cytokine that is a functional ligand for CCR4, is upregulated in various inflammation and autoimmune diseases. CKLF1 contains at least two secreted forms, the C-terminal peptides C19 and C27. Chemically synthesized C19 and C27 can interact with CCR4 and attenuate allergic inflammation. In this study, we found C19 and C27 could inhibit SDF-1-induced CXCR4-mediated chemotaxis and promote CXCR4 internalization. The inhibitory effect was due to desensitization of CXCR4, which was mediated by CCR4. Further experiments confirmed that CXCR4 desensitization required activation of PI3K/PKC pathway. Altogether our data elucidate the mechanism of C19- and C27-induced CXCR4 desensitization. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000291779100036
项目编号2006AA02A305 ; 2009ZX09103-724 ; 30872292 ; 90813025
资助机构National High-Tech Research and Development Program of China ; National Key New Drug Creation Program of China ; National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61100
专题北京大学基础医学院_北京大学人类疾病基因研究中心
作者单位1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100191, Peoples R China
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GB/T 7714
Zhang, Yan,Tian, Linjie,Zheng, Yi,et al. C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,409(2):356-361.
APA Zhang, Yan.,Tian, Linjie.,Zheng, Yi.,Qi, Hui.,Guo, Changyuan.,...&Wang, Ying.(2011).C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,409(2),356-361.
MLA Zhang, Yan,et al."C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 409.2(2011):356-361.
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