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学科主题: 临床医学
题名:
Pathophysiology of Acute Kidney Injury to Chronic Kidney Disease: Maladaptive Repair
作者: Yang, Li1,2,4; Humphreys, Benjamin D.1,2,3; Bonventre, Joseph V.1,2,3; Kellum, JA; Ronco, C; Vincent, JL
刊名: CONTROVERSIES IN ACUTE KIDNEY INJURY
发表日期: 2011
卷: 174, 页:149-155
收录类别: BSCI ; SCI
文章类型: Book Chapter
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Urology & Nephrology
研究领域[WOS]: General & Internal Medicine ; Urology & Nephrology
关键词[WOS]: ACUTE-RENAL-FAILURE ; ISCHEMIA-REPERFUSION INJURY ; EPITHELIAL-CELLS ; DENDRITIC CELLS ; MACROPHAGES ; FIBROSIS ; RAT
英文摘要:

After damage the kidney has the ability to repair itself. With mild injury this repair can result in the return to a structural and functional state that is indistinguishable from normal. However, when the repair is more severe or is superimposed on baseline kidney abnormalities, the repair process can lead to fibrosis, which can facilitate progression to chronic kidney disease. Epidemiological studies now show that patients who have had acute kidney injury have a marked increase in their risk for the development of end-stage renal disease. Recent data have redefined the role of the surviving epithelial cells in fibrosis and attribute myofibroblast expansion to perivascular and interstitial fibroblasts. After severe injury, the proximal tubule cellular response is impaired with its proliferative response altered due to cell cycle arrest at the G2/M phase of the cell cycle, resulting in generation of profibrotic factors including cytokines, growth factors and matrix proteins. Copyright (C) 2011 S. Karger AG, Basel

语种: 英语
WOS记录号: WOS:000299454300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61102
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Harvard Stem Cell Inst, Cambridge, MA USA
2.Beijing Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
3.Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
4.Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA

Recommended Citation:
Yang, Li,Humphreys, Benjamin D.,Bonventre, Joseph V.,et al. Pathophysiology of Acute Kidney Injury to Chronic Kidney Disease: Maladaptive Repair[J]. CONTROVERSIES IN ACUTE KIDNEY INJURY,2011,174:149-155.
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