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学科主题临床医学
Pathophysiology of Acute Kidney Injury to Chronic Kidney Disease: Maladaptive Repair
Yang, Li1,2,4; Humphreys, Benjamin D.1,2,3; Bonventre, Joseph V.1,2,3; Kellum, JA; Ronco, C; Vincent, JL
刊名CONTROVERSIES IN ACUTE KIDNEY INJURY
2011
174页:149-155
收录类别BSCI ; SCI
文章类型Book Chapter
WOS标题词Science & Technology
类目[WOS]Critical Care Medicine ; Urology & Nephrology
研究领域[WOS]General & Internal Medicine ; Urology & Nephrology
关键词[WOS]ACUTE-RENAL-FAILURE ; ISCHEMIA-REPERFUSION INJURY ; EPITHELIAL-CELLS ; DENDRITIC CELLS ; MACROPHAGES ; FIBROSIS ; RAT
英文摘要

After damage the kidney has the ability to repair itself. With mild injury this repair can result in the return to a structural and functional state that is indistinguishable from normal. However, when the repair is more severe or is superimposed on baseline kidney abnormalities, the repair process can lead to fibrosis, which can facilitate progression to chronic kidney disease. Epidemiological studies now show that patients who have had acute kidney injury have a marked increase in their risk for the development of end-stage renal disease. Recent data have redefined the role of the surviving epithelial cells in fibrosis and attribute myofibroblast expansion to perivascular and interstitial fibroblasts. After severe injury, the proximal tubule cellular response is impaired with its proliferative response altered due to cell cycle arrest at the G2/M phase of the cell cycle, resulting in generation of profibrotic factors including cytokines, growth factors and matrix proteins. Copyright (C) 2011 S. Karger AG, Basel

语种英语
WOS记录号WOS:000299454300017
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61102
专题北京大学第一临床医学院_肾脏内科
作者单位1.Harvard Stem Cell Inst, Cambridge, MA USA
2.Beijing Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
3.Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
4.Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
推荐引用方式
GB/T 7714
Yang, Li,Humphreys, Benjamin D.,Bonventre, Joseph V.,et al. Pathophysiology of Acute Kidney Injury to Chronic Kidney Disease: Maladaptive Repair[J]. CONTROVERSIES IN ACUTE KIDNEY INJURY,2011,174:149-155.
APA Yang, Li,Humphreys, Benjamin D.,Bonventre, Joseph V.,Kellum, JA,Ronco, C,&Vincent, JL.(2011).Pathophysiology of Acute Kidney Injury to Chronic Kidney Disease: Maladaptive Repair.CONTROVERSIES IN ACUTE KIDNEY INJURY,174,149-155.
MLA Yang, Li,et al."Pathophysiology of Acute Kidney Injury to Chronic Kidney Disease: Maladaptive Repair".CONTROVERSIES IN ACUTE KIDNEY INJURY 174(2011):149-155.
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