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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸部肿瘤内科  > 期刊论文
学科主题: 临床医学
题名:
EML4-ALK Rearrangement and Its Clinical Significance in Chinese Patients with Advanced Non-Small Cell Lung Cancer
作者: Wang, Zhijie1; Zhang, Xuchao2; Bai, Hua1; Zhao, Jun1; Zhuo, Minglei1; An, Tongtong1; Duan, Jianchun1; Yang, Lu1; Wu, Meina1; Wang, Shuhang1; Wang, Yuyan1; Wu, Yilong2; Wang, Jie1
关键词: Anaplastic lymphoma kinase ; EML4-ALK ; Echinoderm microtubule-associated protein-like 4 ; Epidermal growth factor receptor ; Non-small cell lung cancer ; Tyrosine kinase inhibitors
刊名: ONCOLOGY
发表日期: 2012
DOI: 10.1159/000341381
卷: 83, 期:5, 页:248-256
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: INFLAMMATORY MYOFIBROBLASTIC TUMORS ; FUSION GENE ; PLASMA DNA ; LYMPHOMA ; EGFR ; ALK ; MUTATIONS ; GEFITINIB ; ADENOCARCINOMA ; INHIBITOR
英文摘要:

Objective: To identify the clinicopathological characteristics and clinical outcomes of Chinese patients with non-small cell lung cancer (NSCLC) and to investigate possible associations of NSCLC with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) mutations. Methods: Patients with stage IV NSCLC were screened for EML4-ALK rearrangement and EGFR mutations at the Peking University Cancer Hospital. EML4-ALK was identified using fluorescent in situ hybridization and confirmed by immunohistochemistry. EGFR mutations were determined using denaturing high-performance liquid chromatography. Results: The incidence of EML4-ALK was 9.7% (11/113). Patients with EML4-ALK were more likely to present the EGFR wild type (WT; p = 0.033). Response to EGFR-tyrosine kinase inhibitor (TKI) was similar between patients with EML4-ALK rearrangement and EGFR mutation (33.3 vs. 46.9%, p = 0.451), but progression-free survival (PFS) was inferior compared to those with EGFR mutation (2.1 vs. 8.8 months, p = 0.032), and similar to patients with WT/nonrearrangement (2.1 vs. 2.2 months, p = 0.696; and general p = 0.023 between the three cohorts). Moreover, 2 patients with concurrent EML4-ALK and EGFR mutations had superior PFS after EGFR-TKI compared to patients with single EML4-ALK rearrangement. Conclusions: Patients with EML4-ALK conferred similar objective response rates after EGFR-TKI although inferior PFS compared to those with EGFR mutation. Coexistence of EML4-ALK and EGFR mutation might represent a separate NSCLC genotype. Copyright (C) 2012 S. Karger AG, Basel

语种: 英语
所属项目编号: 81025012 ; 81101778
项目资助者: National Science Fund for Distinguished Young Scholars of China ; National Science Fund for Young Scholars of China
WOS记录号: WOS:000308741800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61108
Appears in Collections:北京大学临床肿瘤学院_胸部肿瘤内科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Thorac Med Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Wang, Zhijie,Zhang, Xuchao,Bai, Hua,et al. EML4-ALK Rearrangement and Its Clinical Significance in Chinese Patients with Advanced Non-Small Cell Lung Cancer[J]. ONCOLOGY,2012,83(5):248-256.
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