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学科主题: 临床医学
题名:
NPM1-mutated acute myeloid leukemia of monocytic or myeloid origin exhibit distinct immunophenotypes
作者: Liu, Yan-Rong; Zhu, Hong-Hu; Ruan, Guo-Rui; Qin, Ya-Zhen; Shi, Hong-Xia; Lai, Yue-Yun; Chang, Yan; Wang, Ya-Zhe; Lu, Dan; Hao, Le; Li, Jin-Lan; Li, Ling-Di; Jiang, Bin; Huang, Xiao-Jun
关键词: Acute myeloid leukemia ; Nucleophosmin mutation ; Immunophenotype ; Flow cytometry
刊名: LEUKEMIA RESEARCH
发表日期: 2013-07-01
DOI: 10.1016/j.leukres.2013.03.009
卷: 37, 期:7, 页:737-741
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: ACUTE MYELOGENOUS LEUKEMIA ; CYTOPLASMIC NUCLEOPHOSMIN ; FAVORABLE PROGNOSIS ; TANDEM DUPLICATION ; NORMAL KARYOTYPE ; GENE-MUTATIONS ; NPM1 MUTATION ; EXPRESSION ; AML ; CLASSIFICATION
英文摘要:

Acute myeloid leukemia with mutated nucleophosmin (NPM1m+AML) is a heterogeneous entity. We investigated whether NPM1m+AML with monocytic or myeloid differentiation have distinct immunophenotype. The study included 160 NPM1m+AMLpatients and 178 AML patients without NPM1 mutation and recurrent cytogenetic abnormality (NPM1wt-AML). We analyzed the immunophenotype by flow cytometry. NPM1 mutation was detected by PCR. Compared with NPM1wt-AML patients, NPM1m+AML patients showed higher positive rates of CD33 and CD9 and lower positive rates of CD34, HLA-DR, CD7, CD15 and CD117 (all P < 0.05). HLA-DR, CD64, CD14, CD11b, CD15, CD4, CD9 and CD10 were higher (P < 0.001) and CD117 was lower (P < 0.01) in monocytic NPM1m+AML compared with myeloid NPM1m+AML. Similar rates of lymphoid antigen (CD19, CD2, and CD7) and myeloid antigen (CD13, CD33) positivity were detected in monocytic and myeloid NPM1m+AML. Compared with NPM1wt-AML, CD34 expression was lower both in myeloid and monocytic NPM1m+AML subgroups, although HLA-DR was lower in NPM1m+AML compared with NPM1wt-AML only in myeloid subgroup. Comparisons of NPM1m+AML and NPM1wt-AML showed no differences in monocyte-associated markers such as CD14 and CD11b in myeloid and monocytic subgroup. Myeloid NPM1m+AML correlated with the female gender (P = 0.001), lower WBC counts (P = 0.04) and higher WT1 transcripts (P = 0.006) compared with monocytic NPM1m+AML. These results suggested monocytic and myeloid-derived NPM1m+AML exhibit distinct immunophenotypes. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011YQ03013407
项目资助者: Special-funded programme on national key scientific instruments and equipment development
WOS记录号: WOS:000320583100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61111
Appears in Collections:北京大学第二临床医学院_北京大学血液病研究所_期刊论文

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作者单位: Peking Univ, Peking Univ Inst Hematol, Dept Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Yan-Rong,Zhu, Hong-Hu,Ruan, Guo-Rui,et al. NPM1-mutated acute myeloid leukemia of monocytic or myeloid origin exhibit distinct immunophenotypes[J]. LEUKEMIA RESEARCH,2013,37(7):737-741.
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