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学科主题临床医学
p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR
Gong, Manman; Meng, Lin; Jiang, Beihai; Zhang, Jianzhi; Yang, Hua; Wu, Jian; Shou, Chengchao
刊名MOLECULAR CANCER THERAPEUTICS
2008-03-01
DOI10.1158/1535-7163.MCT-07-2191
7期:3页:530-537
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]NECROSIS-FACTOR-ALPHA ; MOUSE SARCOMA-CELLS ; GROWTH-FACTOR ; MALIGNANT-TRANSFORMATION ; MEMBRANE GLYCOPROTEIN ; CHROMOSOME CHANGES ; TNF-ALPHA ; CLEAVAGE ; RECEPTOR ; INVITRO
英文摘要

High Mycoplasma infection in gastric cancer tissues suggests a possible association between Mycoplasma infection and tumorigenesis. By using human gastric cancer cells AGS and mouse melanoma cells B16F10 stably expressing p37, the major immunogen of Mycoplasma hyorhinis, we found that p37 enhanced cell motility, migration, and invasion in vitro. With experimental metastasis model in C57BL/6 mice, p37 adenovirus-infected B16F10 cells formed more metastasis lesions in the lung. Furthermore, p37 promoted the phosphorylation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase and the activity of matrix metalloproteinase-2 (MMP-2). Inhibitor of MMPs significantly blocked p37-induced EGFR but has little effect on extracellular signal-regulated kinase phosphorylation, whereas the p37-induced MMP-2 activation was only partially suppressed by inhibitor of MEK1/2 or by inhibitor of EGFR. However, all these inhibitors significantly reduced the p37-induced invasiveness of AGS cells. These results suggest that p37 may stimulate invasion by increasing the activity of MMP-2, thereby inducing EGFR phosphorylation and contributing to tumor metastasis on M. hyorhinis infection. p37 and its regulated molecules could be the potential targets for cancer therapy.

语种英语
WOS记录号WOS:000254312800011
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61112
专题北京大学临床肿瘤学院
北京大学第三临床医学院_检验科
北京大学临床肿瘤学院_胸部肿瘤外二科
北京大学临床肿瘤学院_生化与分子生物学研究室
作者单位Peking Univ, Sch Oncol, Dept Biochem & Mol Biol, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China
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GB/T 7714
Gong, Manman,Meng, Lin,Jiang, Beihai,et al. p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR[J]. MOLECULAR CANCER THERAPEUTICS,2008,7(3):530-537.
APA Gong, Manman.,Meng, Lin.,Jiang, Beihai.,Zhang, Jianzhi.,Yang, Hua.,...&Shou, Chengchao.(2008).p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR.MOLECULAR CANCER THERAPEUTICS,7(3),530-537.
MLA Gong, Manman,et al."p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR".MOLECULAR CANCER THERAPEUTICS 7.3(2008):530-537.
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