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学科主题: 临床医学
题名:
p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR
作者: Gong, Manman; Meng, Lin; Jiang, Beihai; Zhang, Jianzhi; Yang, Hua; Wu, Jian; Shou, Chengchao
刊名: MOLECULAR CANCER THERAPEUTICS
发表日期: 2008-03-01
DOI: 10.1158/1535-7163.MCT-07-2191
卷: 7, 期:3, 页:530-537
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; MOUSE SARCOMA-CELLS ; GROWTH-FACTOR ; MALIGNANT-TRANSFORMATION ; MEMBRANE GLYCOPROTEIN ; CHROMOSOME CHANGES ; TNF-ALPHA ; CLEAVAGE ; RECEPTOR ; INVITRO
英文摘要:

High Mycoplasma infection in gastric cancer tissues suggests a possible association between Mycoplasma infection and tumorigenesis. By using human gastric cancer cells AGS and mouse melanoma cells B16F10 stably expressing p37, the major immunogen of Mycoplasma hyorhinis, we found that p37 enhanced cell motility, migration, and invasion in vitro. With experimental metastasis model in C57BL/6 mice, p37 adenovirus-infected B16F10 cells formed more metastasis lesions in the lung. Furthermore, p37 promoted the phosphorylation of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase and the activity of matrix metalloproteinase-2 (MMP-2). Inhibitor of MMPs significantly blocked p37-induced EGFR but has little effect on extracellular signal-regulated kinase phosphorylation, whereas the p37-induced MMP-2 activation was only partially suppressed by inhibitor of MEK1/2 or by inhibitor of EGFR. However, all these inhibitors significantly reduced the p37-induced invasiveness of AGS cells. These results suggest that p37 may stimulate invasion by increasing the activity of MMP-2, thereby inducing EGFR phosphorylation and contributing to tumor metastasis on M. hyorhinis infection. p37 and its regulated molecules could be the potential targets for cancer therapy.

语种: 英语
WOS记录号: WOS:000254312800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61112
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Dept Biochem & Mol Biol, Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China

Recommended Citation:
Gong, Manman,Meng, Lin,Jiang, Beihai,et al. p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR[J]. MOLECULAR CANCER THERAPEUTICS,2008,7(3):530-537.
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