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学科主题: 临床医学
题名:
Cfr-Mediated Linezolid-Resistance among Methicillin-Resistant Coagulase-Negative Staphylococci from Infections of Humans
作者: Cui, Lanqing1; Wang, Yang2; Li, Yun1; He, Tao2; Schwarz, Stefan3; Ding, Yujing1; Shen, Jianzhong2; Lv, Yuan1
刊名: PLOS ONE
发表日期: 2013-02-20
DOI: 10.1371/journal.pone.0057096
卷: 8, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: 1ST REPORT ; GENE CFR ; AUREUS ; EPIDERMIDIS ; MUTATION ; CHLORAMPHENICOL ; OXAZOLIDINONES ; ISOLATE ; CHINA
英文摘要:

Four methicillin-resistant coagulase-negative staphylococci (MRCoNS), one Staphylococcus haemolyticus and three Staphylococcus cohnii, from infections of humans collected via the Ministry of Health National Antimicrobial Resistance Surveillance Net (Mohnarin) program in China were identified as linezolid-resistant. These four isolates were negative for the 23S rRNA mutations, but positive for the gene cfr. Mutations in the gene for the ribosomal protein L3, which resulted in the amino acid exchanges Gly152Asp and Tyr158Phe, were identified in S. haemolyticus 09D279 and S. cohnii NDM113, respectively. In each isolate, the cfr gene was located on a plasmid of ca. 35.4 kb, as shown by S1 nuclease pulsed-field gel electrophoresis and Southern blotting experiments. This plasmid was indistinguishable from the previously described plasmid pSS-02 by its size, restriction pattern, and a sequenced 14-kb cfr-carrying segment. Plasmid pSS-02 was originally identified in staphylococci isolated from pigs. This is the first time that a cfr-carrying plasmid has been detected in MRCoNS obtained from intensive care patients in China. Based on the similarities to the cfr-carrying plasmid pSS-02 from porcine coagulase-negative staphylococci, a transmission of this cfr-carrying plasmid between staphylococci from pigs and humans appears to be likely.

语种: 英语
所属项目编号: 2012ZX09303005-003 ; 31001087
项目资助者: National Science and Technology Major Project ; National Natural Science Foundation of China
WOS记录号: WOS:000315184200213
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61121
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 1, Inst Clin Pharmacol, Beijing 100871, Peoples R China
2.China Agr Univ, Coll Vet Med, Beijing 100094, Peoples R China
3.FLI, Inst Farm Anim Genet, Neustadt, Germany

Recommended Citation:
Cui, Lanqing,Wang, Yang,Li, Yun,et al. Cfr-Mediated Linezolid-Resistance among Methicillin-Resistant Coagulase-Negative Staphylococci from Infections of Humans[J]. PLOS ONE,2013,8(2).
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