IR@PKUHSC  > 北京大学第三临床医学院  > 麻醉科
学科主题临床医学
Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation
Zhang Li-ping1; Yang Lu1; Bi Shan-shan4; Lu Wei4; Zhang Xian-hua2; Zhai Suo-di2; Duan Li-ping3
关键词remifentanil liver transplantation pharmacokinetics anesthesia
刊名CHINESE MEDICAL JOURNAL
2009-05-05
DOI10.3760/cma.j.issn.0366-6999.2009.09.006
122期:9页:1032-1038
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ADULT MALE-VOLUNTEERS ; CARDIOPULMONARY BYPASS ; HUMAN BLOOD ; PHARMACODYNAMICS ; GI87084B ; SURGERY ; MODEL ; AGE
英文摘要

Backgroud Little is known about the influence of liver transplantation on the pharmacokinetics of most anesthetic drugs. The goal of this study was to study the population pharmacokinetics of remifentanil in the different phases of orthotopic liver transplantation (OLT) and the influence of relevant factors.

Methods Thirteen adult patients undergoing OLT were enrolled. A single bolus infusion of remifentanil 5 mu g/kg was administered during the preanhepatic, anhepatic and neohepatic phases of OLT. Arterial blood samples of 1.5 ml were collected at 0 (baseline), 1, 2, 3, 5, 7, 10, 15, 20, 25, 30, 45, 60 and 90 minutes after drug administration. Remifentanil concentration was assayed by high-performance liquid chromatography/mass spectrometry/mass spectrometry (HPLC/MS/MS). Population pharmacokinetic modeling was performed using nonlinear mixed-effects modeling (NONMEM).

Results The pharmacokinetics of remifentanil in patients undergoing OLT was best described by a two-compartment open model. The pharmacokinetic parameters were not influenced by age, gender, operative phase, blood temperature, rehydration volume, or blood loss volume during sampling. The volume of distribution in the central compartment (Vi) and the volume of distribution in the peripheral compartment (V(2)) were influenced by body weight.

Conclusions The population pharmacokinetics of remifentanil in patients undergoing OLT can be well described by a two-compartment open model. The functional status of the liver does not significantly affect the pharmacokinetics of remifentanil, but the body weight is an influential factor of V(1) and V(2). Chin Med J 2009,122(9):1032-1038

语种英语
WOS记录号WOS:000265903000006
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61122
专题北京大学第三临床医学院_麻醉科
北京大学医学部管理机构_科学研究处
北京大学药学院_药剂学系
作者单位1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang Li-ping,Yang Lu,Bi Shan-shan,et al. Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation[J]. CHINESE MEDICAL JOURNAL,2009,122(9):1032-1038.
APA Zhang Li-ping.,Yang Lu.,Bi Shan-shan.,Lu Wei.,Zhang Xian-hua.,...&Duan Li-ping.(2009).Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation.CHINESE MEDICAL JOURNAL,122(9),1032-1038.
MLA Zhang Li-ping,et al."Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation".CHINESE MEDICAL JOURNAL 122.9(2009):1032-1038.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang Li-ping]的文章
[Yang Lu]的文章
[Bi Shan-shan]的文章
百度学术
百度学术中相似的文章
[Zhang Li-ping]的文章
[Yang Lu]的文章
[Bi Shan-shan]的文章
必应学术
必应学术中相似的文章
[Zhang Li-ping]的文章
[Yang Lu]的文章
[Bi Shan-shan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。