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学科主题: 临床医学
题名:
Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation
作者: Zhang Li-ping1; Yang Lu1; Bi Shan-shan4; Lu Wei4; Zhang Xian-hua2; Zhai Suo-di2; Duan Li-ping3
关键词: remifentanil ; liver transplantation ; pharmacokinetics ; anesthesia
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2009-05-05
DOI: 10.3760/cma.j.issn.0366-6999.2009.09.006
卷: 122, 期:9, 页:1032-1038
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ADULT MALE-VOLUNTEERS ; CARDIOPULMONARY BYPASS ; HUMAN BLOOD ; PHARMACODYNAMICS ; GI87084B ; SURGERY ; MODEL ; AGE
英文摘要:

Backgroud Little is known about the influence of liver transplantation on the pharmacokinetics of most anesthetic drugs. The goal of this study was to study the population pharmacokinetics of remifentanil in the different phases of orthotopic liver transplantation (OLT) and the influence of relevant factors.

Methods Thirteen adult patients undergoing OLT were enrolled. A single bolus infusion of remifentanil 5 mu g/kg was administered during the preanhepatic, anhepatic and neohepatic phases of OLT. Arterial blood samples of 1.5 ml were collected at 0 (baseline), 1, 2, 3, 5, 7, 10, 15, 20, 25, 30, 45, 60 and 90 minutes after drug administration. Remifentanil concentration was assayed by high-performance liquid chromatography/mass spectrometry/mass spectrometry (HPLC/MS/MS). Population pharmacokinetic modeling was performed using nonlinear mixed-effects modeling (NONMEM).

Results The pharmacokinetics of remifentanil in patients undergoing OLT was best described by a two-compartment open model. The pharmacokinetic parameters were not influenced by age, gender, operative phase, blood temperature, rehydration volume, or blood loss volume during sampling. The volume of distribution in the central compartment (Vi) and the volume of distribution in the peripheral compartment (V(2)) were influenced by body weight.

Conclusions The population pharmacokinetics of remifentanil in patients undergoing OLT can be well described by a two-compartment open model. The functional status of the liver does not significantly affect the pharmacokinetics of remifentanil, but the body weight is an influential factor of V(1) and V(2). Chin Med J 2009,122(9):1032-1038

语种: 英语
WOS记录号: WOS:000265903000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61122
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang Li-ping,Yang Lu,Bi Shan-shan,et al. Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation[J]. CHINESE MEDICAL JOURNAL,2009,122(9):1032-1038.
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