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IR@PKUHSC  > 北京大学口腔医学院  > 口腔修复科  > 期刊论文
学科主题: 口腔医学
题名:
A review of the bioactivity of hydraulic calcium silicate cements
作者: Niu, Li-na1; Jiao, Kai2; Wang, Tian-da3; Zhang, Wei4; Camilleri, Josette5; Bergeron, Brian E.6; Feng, Hai-lan3; Mao, Jing4; Chen, Ji-hua1; Pashley, David H.7; Tay, Franklin R.6,7
关键词: Bioactivity ; Calcium silicate ; Hydraulic cement ; In vitro ; In vivo
刊名: JOURNAL OF DENTISTRY
发表日期: 2014-05-01
DOI: 10.1016/j.jdent.2013.12.015
卷: 42, 期:5, 页:517-533
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: MINERAL TRIOXIDE AGGREGATE ; END FILLING MATERIALS ; OSTEOBLAST-LIKE CELLS ; SIMULATED BODY-FLUID ; IN-VITRO BIOACTIVITY ; C-S-H ; TRANSMISSION ELECTRON-MICROSCOPY ; PERIODONTAL-LIGAMENT FIBROBLASTS ; BONELIKE APATITE FORMATION ; PHOSPHATE-CONTAINING FLUID
英文摘要:

Objectives: In tissue regeneration research, the term "bioactivity" was initially used to describe the resistance to removal of a biomaterial from host tissues after intraosseous implantation. Hydraulic calcium silicate cements (HCSCs) are putatively accepted as bioactive materials, as exemplified by the increasing number of publications reporting that these cements produce an apatite-rich surface layer after they contact simulated body fluids.

Methods: In this review, the same definitions employed for establishing in vitro and in vivo bioactivity in glass-ceramics, and the proposed mechanisms involved in these phenomena are used as blueprints for investigating whether HCSCs are bioactive.

Results: The literature abounds with evidence that HCSCs exhibit in vitro bioactivity; however, there is a general lack of stringent methodologies for characterizing the calcium phosphate phases precipitated on HCSCs. Although in vivo bioactivity has been demonstrated for some HCSCs, a fibrous connective tissue layer is frequently identified along the bone-cement interface that is reminiscent of the responses observed in bioinert materials, without accompanying clarifications to account for such observations.

Conclusions: As bone-bonding is not predictably achieved, there is insufficient scientific evidence to substantiate that HCSCs are indeed bioactive. Objective appraisal criteria should be developed for more accurately defining the bioactivity profiles of HCSCs designed for clinical use. Published by Elsevier B.V.

语种: 英语
所属项目编号: R01 DE015306-06 ; 81130078 ; 81300898
项目资助者: NIDCR ; National Nature Science Foundation of China
WOS记录号: WOS:000334745000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61124
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, Xian 710032, Peoples R China
2.Univ Malta, Fac Dent Surg, Dept Restorat Dent, Msida, Malta
3.Georgia Regents Univ, Coll Grad Studies, Augusta, GA USA
4.Fourth Mil Med Univ, Sch Stomatol, Dept Oral Anat & Physiol & TMD, Xian 710032, Peoples R China
5.Peking Univ, Sch Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China
6.Huazhong Univ Sci & Technol, Tongji Hosp, Dept Stomatol, Wuhan 430074, Peoples R China
7.Georgia Regents Univ, Coll Dent Med, Dept Endodont, Augusta, GA USA

Recommended Citation:
Niu, Li-na,Jiao, Kai,Wang, Tian-da,et al. A review of the bioactivity of hydraulic calcium silicate cements[J]. JOURNAL OF DENTISTRY,2014,42(5):517-533.
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