IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Gastro-floating tablets of cephalexin: Preparation and in vitro/in vivo evaluation
Yin, Lifang1,2; Qin, Chao2; Chen, Kaisheng2; Zhu, Chunli3; Cao, Hui2; Zhou, Jianping2; He, Wei2; Zhang, Qiang1
关键词Cephalexin Gastro-floating Sustained-release Absorption study Bioavailability
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2013-08-16
DOI10.1016/j.ijpharm.2013.05.011
452期:1-2页:241-248
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者Ministry of Education of China ; Ministry of Science and Technology of China ; National Basic Research Program of China ; Ministry of Education of China ; Ministry of Science and Technology of China ; National Basic Research Program of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]GASTRORETENTIVE DOSAGE FORMS ; EXTENDED-RELEASE TABLETS ; DRUG-DELIVERY SYSTEMS ; ORAL CEPHALOSPORINS ; MATRIX TABLETS ; RAT STOMACH ; FORMULATION ; PHARMACOKINETICS ; PHARMACOLOGY ; ABSORPTION
英文摘要

Gastro-floating tablets of cephalexin were developed to prolong the residence time in major absorption sites. Gastro-floating tablets were prepared and optimized using hydroxypropyl methylcellulose (HPMC K100M) as matrix and sodium bicarbonate as a gas-forming agent. The properties of the tablets in terms of floating lag time, floating time and in vitro release were evaluated. Furthermore, in vivo pharmacokinetic study in fed and fasted beagle dogs was performed. The gastro-floating tablets had short floating lag time and exhibited a satisfactory sustained-release profile in vitro. Compared with conventional capsules, the gastro-floating tablets presented a sustained-release behavior with a relative bioavailability of 99.4%, while the reference sustained-release tablets gave a relative bioavailability of only 39.3%. Meanwhile, the food had significant effect on the pharmacokinetics of sustained-release tablets. It was concluded that the gastro-floating tablets had a sustained-release effect in vitro and in vivo, as well as desired pharmacokinetic properties in both fed and fasted conditions. (C) 2013 Elsevier B. V. All rights reserved.

语种英语
所属项目编号NECT-08-0846 ; 2009ZX09310-004 ; 2009CB930300
资助者Ministry of Education of China ; Ministry of Science and Technology of China ; National Basic Research Program of China ; Ministry of Education of China ; Ministry of Science and Technology of China ; National Basic Research Program of China
WOS记录号WOS:000321496200029
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61127
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.China Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China
3.Nanjing Kang Bixin Pharmaceut Technol Co Ltd, Nanjing 210046, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Yin, Lifang,Qin, Chao,Chen, Kaisheng,et al. Gastro-floating tablets of cephalexin: Preparation and in vitro/in vivo evaluation[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,452(1-2):241-248.
APA Yin, Lifang.,Qin, Chao.,Chen, Kaisheng.,Zhu, Chunli.,Cao, Hui.,...&Zhang, Qiang.(2013).Gastro-floating tablets of cephalexin: Preparation and in vitro/in vivo evaluation.INTERNATIONAL JOURNAL OF PHARMACEUTICS,452(1-2),241-248.
MLA Yin, Lifang,et al."Gastro-floating tablets of cephalexin: Preparation and in vitro/in vivo evaluation".INTERNATIONAL JOURNAL OF PHARMACEUTICS 452.1-2(2013):241-248.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yin, Lifang]的文章
[Qin, Chao]的文章
[Chen, Kaisheng]的文章
百度学术
百度学术中相似的文章
[Yin, Lifang]的文章
[Qin, Chao]的文章
[Chen, Kaisheng]的文章
必应学术
必应学术中相似的文章
[Yin, Lifang]的文章
[Qin, Chao]的文章
[Chen, Kaisheng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。