北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 老年病内科  > 期刊论文
学科主题: 临床医学
题名:
Antithrombotic therapy in elderly patients with non-valvular atrial fibrillation: a pilot study
作者: Xiang, Wei; Zhang, Jingwei; Liu, Meilin; Liu, Fang; Feng, Xueru; Wang, Yuchuan
关键词: elderly ; atrial fibrillation ; ischemic stroke ; anticoagulation ; CHA(2)DS(2)-VASc score
刊名: CLINICAL INTERVENTIONS IN AGING
发表日期: 2015
DOI: 10.2147/CIA.S67974
卷: 10, 页:515-519
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology
研究领域[WOS]: Geriatrics & Gerontology
关键词[WOS]: ORAL ANTICOAGULANT-THERAPY ; ISCHEMIC-STROKE ; RISK ; CLOPIDOGREL ; POPULATION ; PREVALENCE ; WARFARIN ; ASPIRIN
英文摘要:

Objective: Non-valvular atrial fibrillation (NVAF) is one common arrhythmia in the elderly. However, use of antithrombotic therapy in this population is not well known in the People′s Republic of China. This study aimed at investigating antithrombotic therapy status in elderly patients with NVAF in our hospital.

Methods: A cross-sectional study of consecutive geriatric patients aged >= 60 years with NVAF who discharged from our hospital between January 2012 and December 2013 were collected. CHA(2)DS(2)-VASc score (cardiac failure or dysfunction, hypertension, age >75 [doubled], diabetes, stroke or transient ischemic attack [doubled], vascular disease, age 65-74, and sex category [female]) was used to analyze antithrombotic indication.

Results: We consecutively collected data of 1,000 discharged elderly patients (>= 60 years) with NVAF (mean age 75.3 +/- 8.0 years, 75 years or older 54.7%, female 42.7%). The proportion of paroxysmal atrial fibrillation and non-paroxysmal atrial fibrillation (persistent or permanent) patients were 39.4% and 60.6%, respectively. Among 1,000 patients, 29.1% received oral anticoagulant therapy (OAT), including warfarin (27.8%) and novel oral anticoagulants (1.3%), 39.5% of patients received antiplatelet therapy, and 31.4% received neither therapy. Based on CHA(2)DS(2)-VASc score for stroke risk stratification, 68.9% patients with score >= 1 and 70.2% patients with score >= 2 received antithrombotic therapy, while the rates of OAT were 29.1% and 29.5%, respectively. Among patients with high stroke risk, those with paroxysmal atrial fibrillation were less likely to receive OAT compared with the patients with non-paroxysmal atrial fibrillation (19.5% vs 35.7%, P<0.001). The patients >= 75 years old had lower rate of OAT than the patients <75 years old (25.8% vs 34.8%, P=0.003). The patients with coronary artery disease had lower rate of OAT than the patients without coronary artery disease (24.4% vs 33.4%, P=0.003). Sex and history of stroke or transient ischemic attack had no effect on the use of OAT (30.8% vs 27.9%, P=0.326 and 28.8% vs 29.8%, P=0.761, respectively).

Conclusion: OAT in elderly patients with NVAF in our hospital is underused, especially in those patients with higher risk of stroke.

语种: 英语
所属项目编号: 2012BAI37B05
项目资助者: National Science and Technology Support Program
WOS记录号: WOS:000350634600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61129
Appears in Collections:北京大学第一临床医学院_老年病内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 1, Dept Geriatr, Beijing 100034, Peoples R China

Recommended Citation:
Xiang, Wei,Zhang, Jingwei,Liu, Meilin,et al. Antithrombotic therapy in elderly patients with non-valvular atrial fibrillation: a pilot study[J]. CLINICAL INTERVENTIONS IN AGING,2015,10:515-519.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xiang, Wei]'s Articles
[Zhang, Jingwei]'s Articles
[Liu, Meilin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xiang, Wei]‘s Articles
[Zhang, Jingwei]‘s Articles
[Liu, Meilin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace