IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China
Lai Yue-yun1; Huang Xiao-jun1; Cai Zhen2; Cao Xiang-shan3; Chen Fang-ping4; Chen Xie-qun5; Chen Bao-an6; Fang Mei-yun7; Feng Jia-fu8; Fu Wei-ling9; Guo Hai-ying10; Hou Ming11; Hou Jian12; Hu Yu13; Hu Xiao-tong14; Hu Xiao-mei; Huang Li-qiang16; Jin Jie2; Li Jian-yong17; Li Juan18; Li Wei19; Liang Ying-min20; Liu Ting21; Liu Qi-fa22; Liu Yan-hui23; Mao Ping24; Ouyang Jian25; Qiu Lu-gui26,27,28; Qiu Lin29; Shao Chun-kui30; Shi Bin31; Song Yong-ping32; Sun Zi-min33; Wang Qi-shan34; Wang Chun35; Wang Jian-ming36; Wang Yun-shan37; Wang Zhao38; Wu Jian-bo39; Wu Yin-xia40; Xia Rui-xiang41; Xue Yong-quan42; Yang Bao-zhen43; Yang Guang44; Yang Zheng-lin45; Yu Li46; Yuan Zhong47; Zhang Sheng48; Zhang Yin49; Zhao Hong-guo50; Zhao Li51; Zhou Dao-bin52; Zou Shan-hua53; Zhu Yun-feng54
关键词cytogenetics multiple myeloma in situ hybridization fluorescence
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine

Background Chromosomal abnormalities have been shown to play an important prognostic role in multiple myeloma (MM). Interphase fluorescence in situ hybridization (i-FISH) has been much more effective to identify cytogenetic aberrations in MM than conventional cytogenetic technique (CC). To clearly determine the cytogenetic features of Chinese MM patients and identify their prognostic implications, we designed a multicenter study based on i-FISH including 672 patients from 52 hospitals in China.

Methods All 672 patients were systematically screened for the following genomic aberrations: del(13q), IgH rearrangement, del(p53) and 1q21 amplifications.

Results The analysis showed that the chromosomal changes were detected in 22.1% patients by CC and in 82.3% patients by i-FISH. The most common abnormalities by CC were chromosome 1 aberrations (48.4%), -13/13q- (37.6%), hyperdiploidy (36.6%), hypodiploidy (30.1%) and IgH rearrangements (23.7%). The most frequent abnormalities by FISH was del(13q), which was found in 60.4% patients, whereas IgH rearrangement, 1q21 amplification and p53 deletions were detected in 57.6%, 49.0% and 34.7% cases, respectively. By statistical analysis, -13/13q- by CC was associated with low level of platelet (P=0.015), hyperdiploidy was associated with low level of serum albumin (P=0.028), and IgH rearrangement by FISH was associated with high level of 82 microglobulin (P=0.019). Moreover, 1q21 amplification and del(p53) by FISH conferred a high incidence of progressive disease (PD) after initial therapy. Metaphase detection of IgH rearrangements and chromosome 1 aberrations concurrently was associated with a short progression free survival (PFS) (P=0.036). No significant prognostic implications of other cytogenetic abnormalities were found associated with overall survival and PFS.

Conclusions Chinese MM patients had similar cytogenetic abnormalities compared with the previous reported studies. However, the prognostic significance of FISH aberrations were not clearly determined and further study is required. Chin Med J 2012;125(15):2663-2670

资助机构China Ministry of Public Health
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
作者单位1.Changzheng Hosp Shanghai, Dept Hematol, Shanghai 200003, Peoples R China
2.Jiangsu Prov Hosp, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China
3.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
4.Zhejiang Univ, Affiliated Hosp 1, Dept Hematol, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
5.Soochow Univ, Dept Hematol, Affiliated Hosp 3, Suzhou 213003, Jiangsu, Peoples R China
6.Cent S Univ, Dept Hematol, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China
7.Fourth Mil Med Univ, Dept Hematol, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China
8.Southeast Univ, Dept Hematol, Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China
9.Dalian Med Univ, Dept Hematol, Affiliated Hosp 1, Dalian 116011, Liaoning, Peoples R China
10.Mianyang Cent Hosp, Dept Clin Lab, Mianyang 621000, Sichuan, Peoples R China
11.Third Mil Med Univ, Southwest Hosp, Dept Clin Lab, Chongqing 400038, Peoples R China
12.Third Peoples Hosp Chengdu, Dept Hematol, Chengdu 610031, Sichuan, Peoples R China
13.Shandong Univ, Qilu Hosp, Dept Hematol, Jinan 250012, Shandong, Peoples R China
14.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Hematol, Wuhan 430022, Hubei, Peoples R China
15.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Cent Lab, Hangzhou 310016, Zhejiang, Peoples R China
16.China Acad Chinese Med Sci, Xiyuan Hosp, Dept Hematol, Beijing 100091, Peoples R China
17.Liaoning Prov Benxi Cent Hosp, Dept Hematol, Benxi 117000, Liaoning, Peoples R China
18.Zhongshan Univ, Affiliated Hosp 1, Dept Hematol, Guangzhou 510080, Guangdong, Peoples R China
19.Jilin Univ, Affiliated Hosp 1, Dept Hematol, Changchun 130021, Jilin, Peoples R China
20.Forth Mil Med Univ, Tangdu Hosp, Dept Hematol, Xian 710038, Shaanxi, Peoples R China
21.Sichuan Univ, W China Hosp, Dept Hematol, Chengdu 610041, Sichuan, Peoples R China
22.So Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou 510515, Guangdong, Peoples R China
23.Guangdong Gen Hosp, Dept Pathol, Guangzhou 510080, Guangdong, Peoples R China
24.Guangzhou First Municipal Peoples Hosp, Dept Hematol, Guangzhou 510180, Guangdong, Peoples R China
25.Nanjing Univ, Gulou Hosp, Dept Hematol, Nanjing 210008, Jiangsu, Peoples R China
26.Chinese Acad Med Sci, Inst Hematol, Tianjin 300020, Peoples R China
27.Chinese Acad Med Sci, Hosp Blood Dis, Tianjin 300020, Peoples R China
28.Peking Union Med Coll, Tianjin 300020, Peoples R China
29.Harbin First Hosp, Dept Hematol, Harbin 150010, Heilongjiang, Peoples R China
30.Zhongshan Univ, Affiliated Hosp 3, Dept Pathol, Guangzhou 510530, Guangdong, Peoples R China
31.Capital Med Univ, Fuxing Hosp, Dept Hematol, Beijing 100045, Peoples R China
32.Henan Canc Hosp, Dept Hematol, Zhengzhou 450003, Henan, Peoples R China
33.Anhui Prov Hosp, Dept Hematol, Hefei 230032, Anhui, Peoples R China
34.Changhai Hosp Shanghai, Dept Hematol, Shanghai 200433, Peoples R China
35.Shaanxi Prov Peoples Hosp, Dept Hematol, Xian 710068, Shaanxi, Peoples R China
36.Shanghai First Peoples Hosp, Dept Hematol, Shanghai 200080, Peoples R China
37.Jinan Cent Hosp, Dept Lab Diag Ctr, Jinan 250013, Shandong, Peoples R China
38.Beijing Friendship Hosp, Dept Hematol, Beijing 100050, Peoples R China
39.Wenzhou Med Coll, Affiliated Hosp 1, Dept Hematol, Wenzhou 325000, Zhejiang, Peoples R China
40.Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Internal Med Neurol, Wuhan 430064, Hubei, Peoples R China
41.Anhui Med Univ, Affiliated Hosp 1, Dept Hematol, Hefei 230022, Anhui, Peoples R China
42.Soochow Univ, Affiliated Hosp 1, Dept Hematol, Suzhou 215006, Jiangsu, Peoples R China
43.Ningxia Med Univ, Affiliated Hosp, Dept Med Expt Ctr, Ningxia 750004, Peoples R China
44.Foshan First Peoples Hosp, Inst Clin Med, Foshan 528000, Guangdong, Peoples R China
45.Sichuan Prov Peoples Hosp, Dept Clin Lab Ctr, Chengdu 610072, Sichuan, Peoples R China
46.Chinese Peoples Liberat Army Gen Hosp, Dept Hematol, Beijing 100853, Peoples R China
47.Zunyi Med Univ, Affiliated Hosp, Dept Hematol, Zunyi 563003, Guizhou, Peoples R China
48.Fujian Med Univ, Clin Med Coll 1, Dept Pathol, Fuzhou 350005, Fujian, Peoples R China
49.Henan Prov Peoples Hosp, Dept Hematol, Zhengzhou 450003, Henan, Peoples R China
50.Qingdao Univ, Coll Med, Affiliated Hosp, Dept Hematol, Qingdao 266003, Shandong, Peoples R China
51.Lanzhou Univ, Affiliated Hosp 1, Dept Hematol, Lanzhou 730000, Gansu, Peoples R China
52.Beijing Union Med Coll Hosp, Dept Hematol, Beijing 100730, Peoples R China
53.Fudan Univ, Zhongshan Hosp, Dept Hematol, Shanghai 200032, Peoples R China
54.307 Hosp Peoples Liberat Army, Dept Hematol, Beijing 100101, Peoples R China
GB/T 7714
Lai Yue-yun,Huang Xiao-jun,Cai Zhen,et al. Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China[J]. CHINESE MEDICAL JOURNAL,2012,125(15):2663-2670.
APA Lai Yue-yun.,Huang Xiao-jun.,Cai Zhen.,Cao Xiang-shan.,Chen Fang-ping.,...&Zhu Yun-feng.(2012).Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China.CHINESE MEDICAL JOURNAL,125(15),2663-2670.
MLA Lai Yue-yun,et al."Prognostic power of abnormal cytogenetics for multiple myeloma: a multicenter study in China".CHINESE MEDICAL JOURNAL 125.15(2012):2663-2670.
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