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学科主题: 临床医学
题名:
Association of the DYX1C1 Dyslexia Susceptibility Gene with Orthography in the Chinese Population
作者: Zhang, Yuping1; Li, Jun1; Tardif, Twila2; Burmeister, Margit3,4,5; Villafuerte, Sandra M.3,4; McBride-Chang, Catherine6; Li, Hong7; Shi, Bingjie1; Liang, Weilan8; Zhang, Zhixiang8; Shu, Hua1
刊名: PLOS ONE
发表日期: 2012-09-13
DOI: 10.1371/journal.pone.0042969
卷: 7, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DEVELOPMENTAL DYSLEXIA ; READING DISABILITIES ; CANDIDATE GENE ; CHILDREN ; SUPPORT ; ADOLESCENTS ; CHARACTERS ; VARIANT ; SKILLS ; EKN1
英文摘要:

Several independent studies have supported the association of DYX1C1 with dyslexia, but its role in general reading development remains unclear. Here, we investigated the contribution of this gene to reading, with a focus on orthographic skills, in a sample of 284 unrelated Chinese children aged 5 to 11 years who were participating in the Chinese Longitudinal Study of Reading Development. We tested this association using a quantitative approach for Chinese character reading, Chinese character dictation, orthographic judgment, and visual skills. Significant or marginally significant associations were observed at the marker rs11629841 with children′s orthographic judgments at ages 7 and 8 years (all P values<0.020). Significant associations with Chinese character dictation (all P values<0.013) were also observed for this single-nucleotide polymorphism (SNP) at ages 9, 10, and 11 years. Further analyses revealed that the association with orthographic skills was specific to the processing of specific components of characters (P values<0.046). No association was found at either SNP of rs3743205 or rs57809907. Our findings suggest that DYX1C1 influences reading development in the general Chinese population and supports a universal effect of this gene.

语种: 英语
所属项目编号: 30870758 ; BCS-0350272 ; 448907
项目资助者: Natural Science Foundation of China ; Fundamental Research Funds for the Central University ; U.S. Natural Sciences Foundation ; Research Grants Council of the Hong Kong Special Administrative Region
WOS记录号: WOS:000308788700007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61134
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Univ Michigan, Dept Psychol, Ann Arbor, MI USA
2.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
4.Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA
5.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
6.Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
7.Chinese Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China
8.Beijing Normal Univ, Dept Psychol, Beijing 100875, Peoples R China

Recommended Citation:
Zhang, Yuping,Li, Jun,Tardif, Twila,et al. Association of the DYX1C1 Dyslexia Susceptibility Gene with Orthography in the Chinese Population[J]. PLOS ONE,2012,7(9).
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