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学科主题: 临床医学
题名:
Clinical and serologic features of primary Sjogren′s syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study
作者: Wen, Wen1,2; Liu, Yanying1,2; Zhao, Chuchu1,2; Sun, Xiaolin1,2; Zhang, Chunfang3; Li, Zhanguo1,2
关键词: Anemia ; Autoimmunity ; Cytopenia ; Primary biliary cirrhosis ; Sjogren&prime ; s syndrome
刊名: CLINICAL RHEUMATOLOGY
发表日期: 2015-11-01
DOI: 10.1007/s10067-015-3081-0
卷: 34, 期:11, 页:1877-1884
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: DISEASE
英文摘要:

Autoimmune hemolytic anemia (AIHA) is an uncommon but clinically significant disorder in primary Sjogren′s syndrome (pSS). Among 565 pSS patients hospitalized in Peking University People′s Hospital from January 2000 to March 2013, 16 patients were diagnosed with AIHA (2.8 % prevalence). AIHA presented at the onset of pSS without overt sicca symptoms in 3 of the 16 patients. Primary biliary cirrhosis (PBC) was more prevalent in the patients with SS-AIHA than in those without (p = 0.007). Edema, fever, and liver involvement occurred significantly more frequently in pSS patients with AIHA than those without AIHA (p = 0.035, p = 0.029, p = 0.024, respectively). The pSS patients with AIHA were more vulnerable to leukopenia and thrombocytopenia than those without AIHA (p = 0.004 and p = 0.001, respectively). Additionally, the levels of complement component 3 (C3) and complement component 4 (C4) were significantly lower in the SS-AIHA group (p = 0.008 and p = 0.037, respectively). Taken together, our results indicate that pSS should be considered in the differential diagnosis of AIHA, even in the absence of sicca symptoms. Among pSS patients, the existence of PBC, cytopenia, or hypocomplementemia suggests a higher risk of suffering from AIHA.

语种: 英语
所属项目编号: 2014BAI07B01 ; 81471601 ; 7152150
项目资助者: National Sci-Tech Support Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000363957100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61138
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ Peoples Hosp, Clin Immunol Ctr, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Beijing Key Lab Rheumatism Mech & Immune Diag BZ0, Beijing 100044, Peoples R China
3.Peking Univ Peoples Hosp, Dept Clin Epidemiol & Biostat, Beijing 100044, Peoples R China

Recommended Citation:
Wen, Wen,Liu, Yanying,Zhao, Chuchu,et al. Clinical and serologic features of primary Sjogren′s syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study[J]. CLINICAL RHEUMATOLOGY,2015,34(11):1877-1884.
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