IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Clinical and serologic features of primary Sjogren′s syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study
Wen, Wen1,2; Liu, Yanying1,2; Zhao, Chuchu1,2; Sun, Xiaolin1,2; Zhang, Chunfang3; Li, Zhanguo1,2
关键词Anemia Autoimmunity Cytopenia Primary biliary cirrhosis Sjogren&prime s syndrome
刊名CLINICAL RHEUMATOLOGY
2015-11-01
DOI10.1007/s10067-015-3081-0
34期:11页:1877-1884
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
资助者National Sci-Tech Support Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Sci-Tech Support Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
研究领域[WOS]Rheumatology
关键词[WOS]DISEASE
英文摘要

Autoimmune hemolytic anemia (AIHA) is an uncommon but clinically significant disorder in primary Sjogren′s syndrome (pSS). Among 565 pSS patients hospitalized in Peking University People′s Hospital from January 2000 to March 2013, 16 patients were diagnosed with AIHA (2.8 % prevalence). AIHA presented at the onset of pSS without overt sicca symptoms in 3 of the 16 patients. Primary biliary cirrhosis (PBC) was more prevalent in the patients with SS-AIHA than in those without (p = 0.007). Edema, fever, and liver involvement occurred significantly more frequently in pSS patients with AIHA than those without AIHA (p = 0.035, p = 0.029, p = 0.024, respectively). The pSS patients with AIHA were more vulnerable to leukopenia and thrombocytopenia than those without AIHA (p = 0.004 and p = 0.001, respectively). Additionally, the levels of complement component 3 (C3) and complement component 4 (C4) were significantly lower in the SS-AIHA group (p = 0.008 and p = 0.037, respectively). Taken together, our results indicate that pSS should be considered in the differential diagnosis of AIHA, even in the absence of sicca symptoms. Among pSS patients, the existence of PBC, cytopenia, or hypocomplementemia suggests a higher risk of suffering from AIHA.

语种英语
所属项目编号2014BAI07B01 ; 81471601 ; 7152150
资助者National Sci-Tech Support Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Sci-Tech Support Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号WOS:000363957100007
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61138
Collection北京大学第二临床医学院
作者单位1.Peking Univ Peoples Hosp, Clin Immunol Ctr, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Beijing Key Lab Rheumatism Mech & Immune Diag BZ0, Beijing 100044, Peoples R China
3.Peking Univ Peoples Hosp, Dept Clin Epidemiol & Biostat, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Wen, Wen,Liu, Yanying,Zhao, Chuchu,et al. Clinical and serologic features of primary Sjogren′s syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study[J]. CLINICAL RHEUMATOLOGY,2015,34(11):1877-1884.
APA Wen, Wen,Liu, Yanying,Zhao, Chuchu,Sun, Xiaolin,Zhang, Chunfang,&Li, Zhanguo.(2015).Clinical and serologic features of primary Sjogren′s syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study.CLINICAL RHEUMATOLOGY,34(11),1877-1884.
MLA Wen, Wen,et al."Clinical and serologic features of primary Sjogren′s syndrome concomitant with autoimmune hemolytic anemia: a large-scale cross-sectional study".CLINICAL RHEUMATOLOGY 34.11(2015):1877-1884.
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