IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所
学科主题临床医学
Prediction of Spontaneous HBeAg Seroconversion in HBeAg-Positive Chronic Hepatitis B Patients During the Immune Clearance Phase
Song, Guangjun; Rao, Huiying; Feng, Bo; Wei, Lai
关键词chronic hepatitis B hepatitis B virus HBV DNA HBeAg quantitative assay
刊名JOURNAL OF MEDICAL VIROLOGY
2014-11-01
DOI10.1002/jmv.24032
86期:11页:1838-1844
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
资助者National Science and Technology Major Project for Infectious Diseases Control ; National Science and Technology Major Project for Infectious Diseases Control
研究领域[WOS]Virology
关键词[WOS]HBV DNA LEVELS ; E-ANTIGEN ; HEPATOCELLULAR-CARCINOMA ; NATURAL-HISTORY ; VIRUS-INFECTION ; PEGYLATED INTERFERON-ALPHA-2B ; PEGINTERFERON ALPHA-2A ; ACUTE EXACERBATION ; CHINESE PATIENTS ; GENOTYPE-C
英文摘要

Spontaneous hepatitis B virus (HBV) e antigen (HBeAg) seroconversion is associated with reduced risk of liver-related complications, but is poorly understood. In this study, 113 chronic hepatitis B patients in the immune active HBeAg-positive phase were followed up for 76 weeks. Based on the outcome of liver function, HBeAg, hepatitis B viral e antibody (anti-HBe) and HBV DNA at week 76, 18 patients were classified as spontaneous HBeAg seroconversion group (group A) and 95 patients were classified as non-spontaneous HBeAg seroconversion group (group B). In multivariate logistic regression analysis, only week 28 HBV DNA levels were used for the logistic regression equation, and the odds ratio was 0.505 (95% confidence interval (CI): 0.366-0.697). The areas under the receiver operating characteristic curve for HBV DNA and HBeAg levels at week 28 were 0.824 (P<0.001, 95% CI: 0.720-0.927) and 0.832 (P<0.001, 95% CI: 0.744-0.921), respectively. Based on the maximization of Youden′s index, the optimal cutoff values of HBV DNA and HBeAg levels at week 28 were 3.84 log(10) IU/ml and 1.53 log(10) PEI-U/ml, respectively. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of HBV DNA levels at week 28 were 50.0%, 97.9%, 81.8%, and 91.2%, respectively. The sensitivity, specificity, PPV, and NPV of HBeAg levels at week 28 were 94.4%, 60.0%, 30.9%, and 98.3%, respectively. In conclusion, the dynamic monitoring of HBV DNA and HBeAg levels predicted accurately determines spontaneous HBeAg seroconversion over the duration of 1 year. J. Med. Virol. 86:1838-1844, 2014. (c) 2014 Wiley Periodicals, Inc.

语种英语
所属项目编号2012ZX10002003
资助者National Science and Technology Major Project for Infectious Diseases Control ; National Science and Technology Major Project for Infectious Diseases Control
WOS记录号WOS:000342681200003
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61148
Collection北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Song, Guangjun,Rao, Huiying,Feng, Bo,et al. Prediction of Spontaneous HBeAg Seroconversion in HBeAg-Positive Chronic Hepatitis B Patients During the Immune Clearance Phase[J]. JOURNAL OF MEDICAL VIROLOGY,2014,86(11):1838-1844.
APA Song, Guangjun,Rao, Huiying,Feng, Bo,&Wei, Lai.(2014).Prediction of Spontaneous HBeAg Seroconversion in HBeAg-Positive Chronic Hepatitis B Patients During the Immune Clearance Phase.JOURNAL OF MEDICAL VIROLOGY,86(11),1838-1844.
MLA Song, Guangjun,et al."Prediction of Spontaneous HBeAg Seroconversion in HBeAg-Positive Chronic Hepatitis B Patients During the Immune Clearance Phase".JOURNAL OF MEDICAL VIROLOGY 86.11(2014):1838-1844.
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