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学科主题: 临床医学
题名:
Prediction of Spontaneous HBeAg Seroconversion in HBeAg-Positive Chronic Hepatitis B Patients During the Immune Clearance Phase
作者: Song, Guangjun; Rao, Huiying; Feng, Bo; Wei, Lai
关键词: chronic hepatitis B ; hepatitis B virus ; HBV DNA ; HBeAg ; quantitative assay
刊名: JOURNAL OF MEDICAL VIROLOGY
发表日期: 2014-11-01
DOI: 10.1002/jmv.24032
卷: 86, 期:11, 页:1838-1844
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: HBV DNA LEVELS ; E-ANTIGEN ; HEPATOCELLULAR-CARCINOMA ; NATURAL-HISTORY ; VIRUS-INFECTION ; PEGYLATED INTERFERON-ALPHA-2B ; PEGINTERFERON ALPHA-2A ; ACUTE EXACERBATION ; CHINESE PATIENTS ; GENOTYPE-C
英文摘要:

Spontaneous hepatitis B virus (HBV) e antigen (HBeAg) seroconversion is associated with reduced risk of liver-related complications, but is poorly understood. In this study, 113 chronic hepatitis B patients in the immune active HBeAg-positive phase were followed up for 76 weeks. Based on the outcome of liver function, HBeAg, hepatitis B viral e antibody (anti-HBe) and HBV DNA at week 76, 18 patients were classified as spontaneous HBeAg seroconversion group (group A) and 95 patients were classified as non-spontaneous HBeAg seroconversion group (group B). In multivariate logistic regression analysis, only week 28 HBV DNA levels were used for the logistic regression equation, and the odds ratio was 0.505 (95% confidence interval (CI): 0.366-0.697). The areas under the receiver operating characteristic curve for HBV DNA and HBeAg levels at week 28 were 0.824 (P<0.001, 95% CI: 0.720-0.927) and 0.832 (P<0.001, 95% CI: 0.744-0.921), respectively. Based on the maximization of Youden′s index, the optimal cutoff values of HBV DNA and HBeAg levels at week 28 were 3.84 log(10) IU/ml and 1.53 log(10) PEI-U/ml, respectively. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of HBV DNA levels at week 28 were 50.0%, 97.9%, 81.8%, and 91.2%, respectively. The sensitivity, specificity, PPV, and NPV of HBeAg levels at week 28 were 94.4%, 60.0%, 30.9%, and 98.3%, respectively. In conclusion, the dynamic monitoring of HBV DNA and HBeAg levels predicted accurately determines spontaneous HBeAg seroconversion over the duration of 1 year. J. Med. Virol. 86:1838-1844, 2014. (c) 2014 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 2012ZX10002003
项目资助者: National Science and Technology Major Project for Infectious Diseases Control
WOS记录号: WOS:000342681200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61148
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China

Recommended Citation:
Song, Guangjun,Rao, Huiying,Feng, Bo,et al. Prediction of Spontaneous HBeAg Seroconversion in HBeAg-Positive Chronic Hepatitis B Patients During the Immune Clearance Phase[J]. JOURNAL OF MEDICAL VIROLOGY,2014,86(11):1838-1844.
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