北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 化学生物学系  > 期刊论文
学科主题: 药学
题名:
Differentiation-stimulating potency of differentiated HL60 cells after drug treatment
作者: Wang, Cong; Zhang, Qun; Gou, Bao-Di; Zhang, Tian-Lan; Wang, Kui
关键词: Leukemia ; Drug-differentiated cell ; Cell-induced differentiation ; Tetradecanoylphorbol acetate ; Phorbol ester ; Retinoic acid
刊名: BIOMEDICINE & PHARMACOTHERAPY
发表日期: 2014-06-01
DOI: 10.1016/j.biopha.2014.05.001
卷: 68, 期:5, 页:581-588
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: PROMYELOCYTIC LEUKEMIA-CELLS ; TRANS-RETINOIC ACID ; I CLINICAL-TRIAL ; HL-60 CELLS ; GRANULOCYTIC DIFFERENTIATION ; TERMINAL DIFFERENTIATION ; MYELOID-LEUKEMIA ; PHORBOL DIESTER ; LINE HL-60 ; 12-O-TETRADECANOYLPHORBOL-13-ACETATE
英文摘要:

Differentiation therapy in the treatment of leukemia is often hampered by limitations on using certain pharmaceutical regents or on the required doses due to various reasons, such as drug-resistance and retinoic acid syndrome. To circumvent these problems, a strategy might be developed on the basis of the ability of drug-differentiated cells to stimulate differentiation in leukemia cells. Using the promyelocytic leukemia cell line HL60 as a cell model, we assessed the differentiation-stimulating potency of differentiated granulocytes and monocytes/macrophages after treatments with all-trans retinoic acid (ATRA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), respectively. ATRA- and TPA-differentiated cells were able to stimulate differentiation in fresh HL60 cells, accompanied by inhibition on cell growth to various extents. The differentiated cells of the second generation, especially those originated from TPA treatment, were as potent as the drugs themselves in stimulating differentiation in fresh HL60 cells. On the basis of "differentiation induced by differentiated cells", we explored the feasibility of ex vivo therapy. (C) 2014 Elsevier Masson SAS. All rights reserved.

语种: 英语
所属项目编号: J0830836
项目资助者: Project of National Base for Talent Training in Basic Sciences
WOS记录号: WOS:000342667800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61154
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Cong,Zhang, Qun,Gou, Bao-Di,et al. Differentiation-stimulating potency of differentiated HL60 cells after drug treatment[J]. BIOMEDICINE & PHARMACOTHERAPY,2014,68(5):581-588.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Cong]'s Articles
[Zhang, Qun]'s Articles
[Gou, Bao-Di]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Cong]‘s Articles
[Zhang, Qun]‘s Articles
[Gou, Bao-Di]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace