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Differentiation-stimulating potency of differentiated HL60 cells after drug treatment
Wang, Cong; Zhang, Qun; Gou, Bao-Di; Zhang, Tian-Lan; Wang, Kui
关键词Leukemia Drug-differentiated cell Cell-induced differentiation Tetradecanoylphorbol acetate Phorbol ester Retinoic acid
刊名BIOMEDICINE & PHARMACOTHERAPY
2014-06-01
DOI10.1016/j.biopha.2014.05.001
68期:5页:581-588
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
资助者Project of National Base for Talent Training in Basic Sciences ; Project of National Base for Talent Training in Basic Sciences
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]PROMYELOCYTIC LEUKEMIA-CELLS ; TRANS-RETINOIC ACID ; I CLINICAL-TRIAL ; HL-60 CELLS ; GRANULOCYTIC DIFFERENTIATION ; TERMINAL DIFFERENTIATION ; MYELOID-LEUKEMIA ; PHORBOL DIESTER ; LINE HL-60 ; 12-O-TETRADECANOYLPHORBOL-13-ACETATE
英文摘要

Differentiation therapy in the treatment of leukemia is often hampered by limitations on using certain pharmaceutical regents or on the required doses due to various reasons, such as drug-resistance and retinoic acid syndrome. To circumvent these problems, a strategy might be developed on the basis of the ability of drug-differentiated cells to stimulate differentiation in leukemia cells. Using the promyelocytic leukemia cell line HL60 as a cell model, we assessed the differentiation-stimulating potency of differentiated granulocytes and monocytes/macrophages after treatments with all-trans retinoic acid (ATRA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), respectively. ATRA- and TPA-differentiated cells were able to stimulate differentiation in fresh HL60 cells, accompanied by inhibition on cell growth to various extents. The differentiated cells of the second generation, especially those originated from TPA treatment, were as potent as the drugs themselves in stimulating differentiation in fresh HL60 cells. On the basis of "differentiation induced by differentiated cells", we explored the feasibility of ex vivo therapy. (C) 2014 Elsevier Masson SAS. All rights reserved.

语种英语
所属项目编号J0830836
资助者Project of National Base for Talent Training in Basic Sciences ; Project of National Base for Talent Training in Basic Sciences
WOS记录号WOS:000342667800011
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61154
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Cong,Zhang, Qun,Gou, Bao-Di,et al. Differentiation-stimulating potency of differentiated HL60 cells after drug treatment[J]. BIOMEDICINE & PHARMACOTHERAPY,2014,68(5):581-588.
APA Wang, Cong,Zhang, Qun,Gou, Bao-Di,Zhang, Tian-Lan,&Wang, Kui.(2014).Differentiation-stimulating potency of differentiated HL60 cells after drug treatment.BIOMEDICINE & PHARMACOTHERAPY,68(5),581-588.
MLA Wang, Cong,et al."Differentiation-stimulating potency of differentiated HL60 cells after drug treatment".BIOMEDICINE & PHARMACOTHERAPY 68.5(2014):581-588.
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