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学科主题: 药学
题名:
Proteome analysis of the left ventricle in the vitamin D-3 and nicotine-induced rat vascular calcification model
作者: Wang, Qian-Qian; Zhao, Xin; Pu, Xiao-Ping1
关键词: Vitamin D ; Nicotine ; Vascular calcification ; Left ventricular ; Two-dimensional gel electrophoresis
刊名: JOURNAL OF PROTEOMICS
发表日期: 2011-04-01
DOI: 10.1016/j.jprot.2010.12.010
卷: 74, 期:4, 页:480-489
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: SPONTANEOUSLY HYPERTENSIVE-RATS ; SHOCK-RELATED PROTEIN ; OXIDATIVE STRESS ; PLUS NICOTINE ; ENERGY-METABOLISM ; AORTIC STIFFNESS ; SMOOTH-MUSCLE ; HEART ; HSP20 ; HYPERTROPHY
英文摘要:

Vitamin D-3 and nicotine (VDN) serve as an animal model of arterial calcification. The vascular calcification induced by the VDN model is always accompanied by compensatory left ventricular (LV) hypertrophy and impaired cardiac performance. To determine the possible mechanisms that are responsible for the effects of VDN on the LV, a 2-DE based proteomics approach was used to evaluate the changes in protein expression of the left ventricle in VDN rats, to our knowledge, for the first time. We identified sixteen proteins that were markedly altered and involved in mitochondrial function, heat shock protein activity, myocyte cytoskeleton composition and enzyme activity for energy metabolism. We describe, for the first time, a novel pathway (NDPK) that is involved in LV hypertrophy and enzyme activities of three of the sixteen clinical identified proteins: lactate dehydrogenase (LDH), SOD [Mn] and GST. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2004CB518902
项目资助者: National Program for Key Basic Research Projects
WOS记录号: WOS:000289022900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61155
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Qian-Qian,Zhao, Xin,Pu, Xiao-Ping. Proteome analysis of the left ventricle in the vitamin D-3 and nicotine-induced rat vascular calcification model[J]. JOURNAL OF PROTEOMICS,2011,74(4):480-489.
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