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Transcriptome profiling analysis reveals region-distinctive changes of gene expression in the CNS in response to different moderate restraint stress
Wang, Ke4,5; Xiang, Xiao-Hui1,2,3; He, Fei5; Lin, Li-Bo5; Zhang, Rong1,2,3; Ping, Xing-Jie1,2,3; Han, Ji-Sheng1,2,3; Guo, Ning6; Zhang, Qing-Hua4,5; Cui, Cai-Lian1,2,3; Zhao, Guo-Ping4,5
关键词Cns Microarray Restraint Stress Transcriptome Profile
刊名JOURNAL OF NEUROCHEMISTRY
2010-06-01
DOI10.1111/j.1471-4159.2010.06679.x
113期:6页:1436-1446
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
资助者Ministry of Science and Technology of China ; Ministry of Science and Technology of China
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]SPATIAL MEMORY FORMATION ; GINKGO-BILOBA EXTRACT ; C-FOS EXPRESSION ; HIGH-FAT DIET ; PERIAQUEDUCTAL GRAY ; PARAVENTRICULAR NUCLEUS ; BIOMEDICAL-RESEARCH ; KINASE ISOFORMS ; ARCUATE NUCLEUS ; LOCUS-COERULEUS
英文摘要

P>It is generally believed that temporary moderate stress to a living organism has protective and adaptive effects, but little is known about the responses of CNS to the moderate stresses at molecular level. This study aims to investigate the gene expression changes induced by moderate stress in CNS stress- and nociception-related regions of rats. Moderate restraint was applied to rats for 50 min and cDNA microarrays were used to detect the differential gene expression in different CNS regions. Transcriptome profiling analysis showed that at acute stage stress-related genes were up-regulated in arcuate nucleus; fight-or-flight behavior-related genes were up-regulated in periaqueductal gray, while nitric oxide and GABA signal transmission-related genes were up-regulated in spinal dorsal horn. In addition, immune-related genes were broadly regulated, especially at the late stage. These results suggested that specific genes of certain gene ontology categories were spatiotemporally regulated in specific CNS regions related to relevant functions under moderate external stimuli at acute stage, while immune response was broadly regulated at the late stage. The co-regulated genes among the three different CNS regions may play general roles in CNS when exposed to moderate stress. Furthermore, these results will help to elucidate the physiological processes involved in moderate stress in CNS.

语种英语
所属项目编号2007CB512501
资助者Ministry of Science and Technology of China ; Ministry of Science and Technology of China
WOS记录号WOS:000278309900007
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61168
专题基础医学院_神经生物学系
作者单位1.Natl Engn Res Ctr Biochip Shanghai, Shanghai, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Minist Publ Hlth, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Key Lab Neurosci,Minist Educ, Beijing 100191, Peoples R China
5.Shanghai Univ Tradit Chinese Med, Grad Sch, Shanghai, Peoples R China
6.Shanghai Univ Tradit Chinese Med, Ctr Chinese Med Therapy & Syst Biol, Shanghai, Peoples R China
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GB/T 7714
Wang, Ke,Xiang, Xiao-Hui,He, Fei,et al. Transcriptome profiling analysis reveals region-distinctive changes of gene expression in the CNS in response to different moderate restraint stress[J]. JOURNAL OF NEUROCHEMISTRY,2010,113(6):1436-1446.
APA Wang, Ke.,Xiang, Xiao-Hui.,He, Fei.,Lin, Li-Bo.,Zhang, Rong.,...&Zhao, Guo-Ping.(2010).Transcriptome profiling analysis reveals region-distinctive changes of gene expression in the CNS in response to different moderate restraint stress.JOURNAL OF NEUROCHEMISTRY,113(6),1436-1446.
MLA Wang, Ke,et al."Transcriptome profiling analysis reveals region-distinctive changes of gene expression in the CNS in response to different moderate restraint stress".JOURNAL OF NEUROCHEMISTRY 113.6(2010):1436-1446.
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