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学科主题: 临床医学
题名:
Relationship between HLA-DQA1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy
作者: Liu, W; Li, WM; Sun, NL
关键词: polymorphism ; idiopathic dilated cardiomyopathy
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2004-10-01
卷: 117, 期:10, 页:1449-1452
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
英文摘要:

Background Autoimmune mechanisms are likely to participate in the pathogenesis of subgroup of idiopathic dilated cardiomyopathy ( IDC), and components of the major histocompatibility complex may serve as markers for the propensity to develop immune-mediated myocardial damage. Human leukocyte antigen ( HLA) class II genes especially highly polymorphic HLA-DQ genes, play an important role in the activation of immune responses, and thus control the predisposition for or protect from IDC. This study was conducted to investigate the HLA-DQA1 allele polymorphisms in IDC patients and to explore the underlying immunological mechanism and the hereditary susceptibility to IDC.

Methods The polymerase chain reaction sequence-specific primers (PCR-SSP) technique was used to analyze the polymorphisms in the second exon of DQA1 in three groups: 72 IDC patients diagnosed according to the criteria of World Health Organization ( IDC group); 100 end-stage heart failure patients suffering from a disease of known etiology ( HF group); and 100 healthy subjects enrolled for the study during a routine health survey ( control group). Patients in the IDC group were stratified according to ejection fraction ( EF). Those with EF values were higher than 35% were placed into subgroup 1; subgroup 2 included patients with an EF value of 15% -35%; and subgroup 3 consisted of those whose EF values less than 15%.

Results The frequency of HLA-DQA1 *0501 alleles was significantly higher in the IDC group (0.39) than that in the HF group (0.12) and the control group (0.09) (both P < 0.05). Further analysis of the three IDC subgroups showed a higher frequency of DQA1 * 0501 among patients with lower EF values (both P < 0.05, compared with subgroups 1 and 2). The frequency of DQA1 *0201 was higher in the control group than that in the IDC group ( P < 0.05).

Conclusions The HLA-DQA1 *0501 allele confers susceptibility to IDC, while the DQA1 *0201 allele confers protection against it, which indicates that genetic background involved in IDC and heart failure is different. HLA-DQA1 genes are involved in the regulation of specific immune responses by auto- or foreign anti-myocardium antibody.

语种: 英语
WOS记录号: WOS:000224787500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61176
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Harbin Med Coll, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, W,Li, WM,Sun, NL. Relationship between HLA-DQA1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy[J]. CHINESE MEDICAL JOURNAL,2004,117(10):1449-1452.
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