IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Relationship between HLA-DQA1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy
Liu, W; Li, WM; Sun, NL
关键词polymorphism idiopathic dilated cardiomyopathy
刊名CHINESE MEDICAL JOURNAL
2004-10-01
117期:10页:1449-1452
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
英文摘要

Background Autoimmune mechanisms are likely to participate in the pathogenesis of subgroup of idiopathic dilated cardiomyopathy ( IDC), and components of the major histocompatibility complex may serve as markers for the propensity to develop immune-mediated myocardial damage. Human leukocyte antigen ( HLA) class II genes especially highly polymorphic HLA-DQ genes, play an important role in the activation of immune responses, and thus control the predisposition for or protect from IDC. This study was conducted to investigate the HLA-DQA1 allele polymorphisms in IDC patients and to explore the underlying immunological mechanism and the hereditary susceptibility to IDC.

Methods The polymerase chain reaction sequence-specific primers (PCR-SSP) technique was used to analyze the polymorphisms in the second exon of DQA1 in three groups: 72 IDC patients diagnosed according to the criteria of World Health Organization ( IDC group); 100 end-stage heart failure patients suffering from a disease of known etiology ( HF group); and 100 healthy subjects enrolled for the study during a routine health survey ( control group). Patients in the IDC group were stratified according to ejection fraction ( EF). Those with EF values were higher than 35% were placed into subgroup 1; subgroup 2 included patients with an EF value of 15% -35%; and subgroup 3 consisted of those whose EF values less than 15%.

Results The frequency of HLA-DQA1 *0501 alleles was significantly higher in the IDC group (0.39) than that in the HF group (0.12) and the control group (0.09) (both P < 0.05). Further analysis of the three IDC subgroups showed a higher frequency of DQA1 * 0501 among patients with lower EF values (both P < 0.05, compared with subgroups 1 and 2). The frequency of DQA1 *0201 was higher in the control group than that in the IDC group ( P < 0.05).

Conclusions The HLA-DQA1 *0501 allele confers susceptibility to IDC, while the DQA1 *0201 allele confers protection against it, which indicates that genetic background involved in IDC and heart failure is different. HLA-DQA1 genes are involved in the regulation of specific immune responses by auto- or foreign anti-myocardium antibody.

语种英语
WOS记录号WOS:000224787500002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61176
专题北京大学第二临床医学院_心血管内科
作者单位1.Harbin Med Coll, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Liu, W,Li, WM,Sun, NL. Relationship between HLA-DQA1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy[J]. CHINESE MEDICAL JOURNAL,2004,117(10):1449-1452.
APA Liu, W,Li, WM,&Sun, NL.(2004).Relationship between HLA-DQA1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy.CHINESE MEDICAL JOURNAL,117(10),1449-1452.
MLA Liu, W,et al."Relationship between HLA-DQA1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy".CHINESE MEDICAL JOURNAL 117.10(2004):1449-1452.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, W]的文章
[Li, WM]的文章
[Sun, NL]的文章
百度学术
百度学术中相似的文章
[Liu, W]的文章
[Li, WM]的文章
[Sun, NL]的文章
必应学术
必应学术中相似的文章
[Liu, W]的文章
[Li, WM]的文章
[Sun, NL]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。