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学科主题: 药学
题名:
STUDIES ON THE SYNTHESIS OF NICOTINAMIDE NUCLEOSIDE AND NUCLEOTIDE ANALOGUES AND THEIR INHIBITIONS TOWARDS CD38 NADASE
作者: Chen, Zhe1; Kwong, Anna Ka Yee2; Yang, Zhenjun1; Zhang, Liangren1; Lee, Hon Cheung2; Zhang, Lihe1
关键词: Nucleoside ; Nicotinamide Nucleoside ; Nicotinamide Nucleotide ; Synthesis ; Inhibitor of CD38
刊名: HETEROCYCLES
发表日期: 2011-12-01
DOI: 10.3987/COM-11-12361
卷: 83, 期:12, 页:2837-+
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: INOSINE MONOPHOSPHATE DEHYDROGENASE ; ADENINE-DINUCLEOTIDE ; MEDICINAL CHEMISTRY ; H-PHOSPHONATES ; CYCLIZATION ; MECHANISM ; RIBOSE ; PHOSPHATE ; FLUORINE ; NAD(+)
英文摘要:

Nicotinamide adenine dinucleotide (NAD) analogues inhibit the NADase activity of CD38. In the current study, efficient protocols for the synthesis of substituted-nicotinamide nucleosides and nucleotides were developed. The one-pot phosphorylation esterification strategy provides a convenient way of obtaining nicotinamide nucleoside phosphodiesters from the corresponding nucleosides. Structure activity relationship information revealed that replacement of 3′-hydroxy group with F or N-3 led to the considerably decrease of activity as compared with ara-F NMN. Phosphodiesterification of nicotinamide nucleosides lowers their inhibitory activities in some extent.

语种: 英语
所属项目编号: 20910094 ; 90713005 ; 81172917 ; 200800010078 ; N_HKU 722/08 ; 769107 ; 768408 ; 769309 ; 770610
项目资助者: National Natural Sciences Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; NSFC/RGC ; General Research Fund of Hong Kong
WOS记录号: WOS:000298213100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61177
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Chen, Zhe,Kwong, Anna Ka Yee,Yang, Zhenjun,et al. STUDIES ON THE SYNTHESIS OF NICOTINAMIDE NUCLEOSIDE AND NUCLEOTIDE ANALOGUES AND THEIR INHIBITIONS TOWARDS CD38 NADASE[J]. HETEROCYCLES,2011,83(12):2837-+.
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