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STUDIES ON THE SYNTHESIS OF NICOTINAMIDE NUCLEOSIDE AND NUCLEOTIDE ANALOGUES AND THEIR INHIBITIONS TOWARDS CD38 NADASE
Chen, Zhe1; Kwong, Anna Ka Yee2; Yang, Zhenjun1; Zhang, Liangren1; Lee, Hon Cheung2; Zhang, Lihe1
关键词Nucleoside Nicotinamide Nucleoside Nicotinamide Nucleotide Synthesis Inhibitor of CD38
刊名HETEROCYCLES
2011-12-01
DOI10.3987/COM-11-12361
83期:12页:2837-+
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]INOSINE MONOPHOSPHATE DEHYDROGENASE ; ADENINE-DINUCLEOTIDE ; MEDICINAL CHEMISTRY ; H-PHOSPHONATES ; CYCLIZATION ; MECHANISM ; RIBOSE ; PHOSPHATE ; FLUORINE ; NAD(+)
英文摘要

Nicotinamide adenine dinucleotide (NAD) analogues inhibit the NADase activity of CD38. In the current study, efficient protocols for the synthesis of substituted-nicotinamide nucleosides and nucleotides were developed. The one-pot phosphorylation esterification strategy provides a convenient way of obtaining nicotinamide nucleoside phosphodiesters from the corresponding nucleosides. Structure activity relationship information revealed that replacement of 3′-hydroxy group with F or N-3 led to the considerably decrease of activity as compared with ara-F NMN. Phosphodiesterification of nicotinamide nucleosides lowers their inhibitory activities in some extent.

语种英语
WOS记录号WOS:000298213100009
项目编号20910094 ; 90713005 ; 81172917 ; 200800010078 ; N_HKU 722/08 ; 769107 ; 768408 ; 769309 ; 770610
资助机构National Natural Sciences Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; NSFC/RGC ; General Research Fund of Hong Kong
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61177
专题北京大学药学院
北京大学药学院_药物化学系
北京大学第二临床医学院_妇科
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Chen, Zhe,Kwong, Anna Ka Yee,Yang, Zhenjun,et al. STUDIES ON THE SYNTHESIS OF NICOTINAMIDE NUCLEOSIDE AND NUCLEOTIDE ANALOGUES AND THEIR INHIBITIONS TOWARDS CD38 NADASE[J]. HETEROCYCLES,2011,83(12):2837-+.
APA Chen, Zhe,Kwong, Anna Ka Yee,Yang, Zhenjun,Zhang, Liangren,Lee, Hon Cheung,&Zhang, Lihe.(2011).STUDIES ON THE SYNTHESIS OF NICOTINAMIDE NUCLEOSIDE AND NUCLEOTIDE ANALOGUES AND THEIR INHIBITIONS TOWARDS CD38 NADASE.HETEROCYCLES,83(12),2837-+.
MLA Chen, Zhe,et al."STUDIES ON THE SYNTHESIS OF NICOTINAMIDE NUCLEOSIDE AND NUCLEOTIDE ANALOGUES AND THEIR INHIBITIONS TOWARDS CD38 NADASE".HETEROCYCLES 83.12(2011):2837-+.
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