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学科主题: 临床医学
题名:
Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection
作者: Che, Wenliang1; Zhang, Buchun1; Liu, Wenling2; Wei, Yidong1; Xu, Yawei1; Hu, Dayi2
刊名: MEDIATORS OF INFLAMMATION
发表日期: 2012
DOI: 10.1155/2012/730923
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: CARDIOVASCULAR EVENTS ; RISK ; MYOCARDITIS ; PREVENTION ; DISEASE
英文摘要:

Background. Prior study showed HCV-infected patients have increased serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and a possible left ventricular diastolic dysfunction. The objectives of the present paper were to investigate the characteristics of hs-CRP and its correlation with clinical profiles including NT-proBNP and echocardiographic variables in HCV-infected patients. Methods and Results. A total of 106 HCV-infected patients and 106 control healthy individuals were enrolled. The level of serum hs-CRP (median 1.023 mg/L, range 0.03 similar to 5.379 mg/L) was significantly lower in all 106 patients than that in controls (median 3.147 mg/L, range 0.08 similar to 7.36 mg/L, P = 0.012). Although hs-CRP did not correlate significantly with NT-proBNP when all patients and controls were included (r = 0.169, P = 0.121), simple regression analysis demonstrated a statistically significant linear correlation between hs-CRP and NT-proBNP in HCV-infected patients group (r = 0.392, P = 0.017). Independent correlates of hs-CRP levels (R-2 = 0.13) were older age (beta′ = 0.031, P = 0.025) and NT proBNP (beta′ = 0.024, P = 0.017). Conclusions. Although the level of serum hs-CRP decreased significantly, there was a significant association between hs-CRP and NT-proBNP in HCV-infected patients.

语种: 英语
所属项目编号: 2009KJ011 ; 1501219024 ; 11ZR1428200
项目资助者: Natural Science Foundation of Tongji University ; Shanghai Natural Science Foundation of China
WOS记录号: WOS:000304968100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61185
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai 200072, Peoples R China
2.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100044, Peoples R China

Recommended Citation:
Che, Wenliang,Zhang, Buchun,Liu, Wenling,et al. Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection[J]. MEDIATORS OF INFLAMMATION,2012.
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