IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent
Zhong, Shao-Min; Sun, Nan; Liu, Hui-Xian; Niu, Yue-Qing; Wu, Yan
关键词lignin peroxidase melanin melasma skin lightening emulsions statistics
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2015-02-01
DOI10.3892/etm.2014.2118
9期:2页:341-344
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者Syneron Medical Inc. ; Syneron Medical Inc.
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]PHANEROCHAETE-CHRYSOSPORIUM ; DECOLORIZATION ; GUIDELINES ; MELANIN ; TRIALS
英文摘要

The aim of the present study was to evaluate the efficacy and safety of lignin peroxidase (LIP) as a skin-lightening agent in patients with melasma. A self-controlled clinical study was performed in 31 women who had melasma on both sides of the face. This study involved 8 weeks of a full-face product treatment. The skin color was measured at days 0, 7, 28 and 56 using a chromameter on the forehead and cheeks. Standardized digital photographic images of each side of the face of all subjects were captured by a complexion analysis system. Clinical scores of the pigmentation were determined by two dermatologists. After using the LIP whitening lotion for 7 days, the luminance (L*) values of the melasma and the normal skin were significantly increased from baseline. The L* values continued to increase at days 28 and 56. The melasma area severity index (MASI) score was statistically decreased after 28 days of treatment. No treatment-related adverse events were observed. LIP whitening lotion was able to eliminate the skin pigmentation after 7 days of treatment, and provides a completely innovative approach to rapid skin lightening. The LIP whitening lotion exhibited good compatibility and was well tolerated.

语种英语
资助者Syneron Medical Inc. ; Syneron Medical Inc.
WOS记录号WOS:000349506900009
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61187
Collection北京大学第一临床医学院_皮肤性病科
作者单位Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Zhong, Shao-Min,Sun, Nan,Liu, Hui-Xian,et al. Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2015,9(2):341-344.
APA Zhong, Shao-Min,Sun, Nan,Liu, Hui-Xian,Niu, Yue-Qing,&Wu, Yan.(2015).Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent.EXPERIMENTAL AND THERAPEUTIC MEDICINE,9(2),341-344.
MLA Zhong, Shao-Min,et al."Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent".EXPERIMENTAL AND THERAPEUTIC MEDICINE 9.2(2015):341-344.
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