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A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood
Yang, Zhixian; Liu, Xiaoyan; Qin, Jiong; Zhang, Yuehua; Bao, Xinhua; Chang, Xingzhi; Wang, Shuang; Wu, Ye; Xiong, Hui
关键词Epileptic negative myoclonus Atypical benign partial epilepsy Benign childhood epilepsy with centrotemporal spikes Electroenceph-alogram Surface electromyogram Treatment
刊名BRAIN & DEVELOPMENT
2009-04-01
DOI10.1016/j.braindev.2008.04.004
31期:4页:274-281
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CENTROTEMPORAL SPIKES ; CARBAMAZEPINE ; ETHOSUXIMIDE ; AGGRAVATION ; SEIZURES ; ATONIA
英文摘要

Objective. To investigate the clinical and neurophysiological characteristics, particularly therapeutic considerations, of epileptic negative myoclonus (ENM) in atypical benign partial epilepsy (ABPE) of childhood. Methods. From 1998 to 2006, 14/242 patients with benign children epilepsy with centrotemporal spikes (BECTS) were diagnosed as having ABPE with ENM. In all 14 patients, we performed video-EEG monitoring along with tests with the patient′s arms outstretched; 6/14 patients were also simultaneously underwent surface electromyogram (EMG). ENM manifestations, electrophysiological features, and responses to antiepileptic drugs were analyzed. Results. In all cases, ENM developed after the onset of epilepsy and during antiepileptic drug therapy, and the appearance of ENM were corresponding to EEG findings of high-amplitude spikes followed by a slow wave in the contralateral motor areas with secondary generalization. This was further confirmed by time-locked silent EMG. During ENM occurrence or recurrence, habitual seizures and interictal discharges were exaggerated. In some patients, the changes in antiepileptic drug regimens in relation to ENM appearance included add-on therapy with carbamazepine. oxcarbazepine, and phenobarbital or withdrawal of valproate. ENM was controlled in most cases by administration of various combinations of valproate, clonazepam, and corticosteroids. Conclusion. The incidence of ENM or ABPE in our center was approximately 5.79%. A combination of video-EEG monitoring with the patient′s arms outstretched and EMG is essential to identify ENM. The aggravation of habitual seizures and interictal discharges indicate ENM. Some antiepileptic drugs, such as carbamazepine, oxcarbazepine, and phenobarbital, may be related to ENM occurrence during spontaneous aggravation of ABPE. Various combinations of valproate, benzodiazepines, and corticosteroids are relatively effective for treating ENM that Occurs in ABPE. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000264172300002
资助机构Research Foundation of Peking University First Hospital
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61189
专题北京大学第一临床医学院_儿科
北京大学第二临床医学院_儿科
作者单位Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yang, Zhixian,Liu, Xiaoyan,Qin, Jiong,et al. A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood[J]. BRAIN & DEVELOPMENT,2009,31(4):274-281.
APA Yang, Zhixian.,Liu, Xiaoyan.,Qin, Jiong.,Zhang, Yuehua.,Bao, Xinhua.,...&Xiong, Hui.(2009).A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood.BRAIN & DEVELOPMENT,31(4),274-281.
MLA Yang, Zhixian,et al."A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood".BRAIN & DEVELOPMENT 31.4(2009):274-281.
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