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学科主题: 临床医学
题名:
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood
作者: Yang, Zhixian; Liu, Xiaoyan; Qin, Jiong; Zhang, Yuehua; Bao, Xinhua; Chang, Xingzhi; Wang, Shuang; Wu, Ye; Xiong, Hui
关键词: Epileptic negative myoclonus ; Atypical benign partial epilepsy ; Benign childhood epilepsy with centrotemporal spikes ; Electroenceph-alogram ; Surface electromyogram ; Treatment
刊名: BRAIN & DEVELOPMENT
发表日期: 2009-04-01
DOI: 10.1016/j.braindev.2008.04.004
卷: 31, 期:4, 页:274-281
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CENTROTEMPORAL SPIKES ; CARBAMAZEPINE ; ETHOSUXIMIDE ; AGGRAVATION ; SEIZURES ; ATONIA
英文摘要:

Objective. To investigate the clinical and neurophysiological characteristics, particularly therapeutic considerations, of epileptic negative myoclonus (ENM) in atypical benign partial epilepsy (ABPE) of childhood. Methods. From 1998 to 2006, 14/242 patients with benign children epilepsy with centrotemporal spikes (BECTS) were diagnosed as having ABPE with ENM. In all 14 patients, we performed video-EEG monitoring along with tests with the patient′s arms outstretched; 6/14 patients were also simultaneously underwent surface electromyogram (EMG). ENM manifestations, electrophysiological features, and responses to antiepileptic drugs were analyzed. Results. In all cases, ENM developed after the onset of epilepsy and during antiepileptic drug therapy, and the appearance of ENM were corresponding to EEG findings of high-amplitude spikes followed by a slow wave in the contralateral motor areas with secondary generalization. This was further confirmed by time-locked silent EMG. During ENM occurrence or recurrence, habitual seizures and interictal discharges were exaggerated. In some patients, the changes in antiepileptic drug regimens in relation to ENM appearance included add-on therapy with carbamazepine. oxcarbazepine, and phenobarbital or withdrawal of valproate. ENM was controlled in most cases by administration of various combinations of valproate, clonazepam, and corticosteroids. Conclusion. The incidence of ENM or ABPE in our center was approximately 5.79%. A combination of video-EEG monitoring with the patient′s arms outstretched and EMG is essential to identify ENM. The aggravation of habitual seizures and interictal discharges indicate ENM. Some antiepileptic drugs, such as carbamazepine, oxcarbazepine, and phenobarbital, may be related to ENM occurrence during spontaneous aggravation of ABPE. Various combinations of valproate, benzodiazepines, and corticosteroids are relatively effective for treating ENM that Occurs in ABPE. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
项目资助者: Research Foundation of Peking University First Hospital
WOS记录号: WOS:000264172300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61189
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Yang, Zhixian,Liu, Xiaoyan,Qin, Jiong,et al. A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood[J]. BRAIN & DEVELOPMENT,2009,31(4):274-281.
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