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Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes
Ma, Xu; Zhou, Jia; Zhang, Cheng-Xiang; Li, Xiu-Ying; Li, Nan; Ju, Rui-Jun; Shi, Ji-Feng; Sun, Meng-Ge; Zhao, Wei-Yu; Mu, Li-Min; Yan, Yan; Lu, Wan-Liang
关键词Targeting berberine liposomes Mitochondrial signaling pathways ATP-binding cassette transporters Breast cancer stem cells Relapse
刊名BIOMATERIALS
2013-06-01
DOI10.1016/j.biomaterials.2013.02.066
34期:18页:4452-4465
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]MULTIDRUG-RESISTANCE ; SIDE POPULATION ; P-GLYCOPROTEIN ; CYTOCHROME-C ; BCL-2 FAMILY ; IN-VITRO ; MITOCHONDRIA ; IDENTIFICATION ; SUPPRESSION ; EXPRESSION
英文摘要

The recurrence of breast cancer is associated with drug-resistance of cancer stem cells (CSCs), while overexpression of cell membrane ATP-binding cassette (ABC) transporters and resistance of mitochondrial apoptosis-related proteins are responsible for the drug-resistance of CSCs. The targeting berberine liposomes were developed to modulate the resistant membrane and mitochondrial proteins of breast CSCs for the treatment and prevention of breast cancer relapse. Evaluations were performed on human breast CSCs and CSC xenografts in nude mice. The targeting berberine liposomes were shown to cross the CSC membrane, inhibit ABC transporters (ABCC1, ABCC2, ABCC3, ABCG2) and selectively accumulate in the mitochondria. Furthermore, the pro-apoptotic protein Bax was activated while the anti-apoptotic protein Bcl-2 was inhibited resulting in opening of the mitochondrial permeability transition pores, release of cytochrome c, and activation of caspase-9/caspase-3 enzymes. Significant efficacy of the administrations in mice was observed, indicating that the targeting berberine liposomes are a potential therapy for the treatment and prevention of breast cancer relapse arising from CSCs. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000317884800006
项目编号2013CB932501 ; 81172991 ; 7131009 ; BMU20110263
资助机构National Basic Research Program of China (973 program) ; National Science Foundation of China ; Beijing Natural Science Foundation ; Innovation Team of Ministry of Education
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61196
专题北京大学药学院
医学人文研究院/公共教学部_哲学与社会科学系
北京大学第一临床医学院_检验科
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Ma, Xu,Zhou, Jia,Zhang, Cheng-Xiang,et al. Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes[J]. BIOMATERIALS,2013,34(18):4452-4465.
APA Ma, Xu.,Zhou, Jia.,Zhang, Cheng-Xiang.,Li, Xiu-Ying.,Li, Nan.,...&Lu, Wan-Liang.(2013).Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes.BIOMATERIALS,34(18),4452-4465.
MLA Ma, Xu,et al."Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes".BIOMATERIALS 34.18(2013):4452-4465.
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