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学科主题: 药学
题名:
Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes
作者: Ma, Xu; Zhou, Jia; Zhang, Cheng-Xiang; Li, Xiu-Ying; Li, Nan; Ju, Rui-Jun; Shi, Ji-Feng; Sun, Meng-Ge; Zhao, Wei-Yu; Mu, Li-Min; Yan, Yan; Lu, Wan-Liang
关键词: Targeting berberine liposomes ; Mitochondrial signaling pathways ; ATP-binding cassette transporters ; Breast cancer stem cells ; Relapse
刊名: BIOMATERIALS
发表日期: 2013-06-01
DOI: 10.1016/j.biomaterials.2013.02.066
卷: 34, 期:18, 页:4452-4465
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: MULTIDRUG-RESISTANCE ; SIDE POPULATION ; P-GLYCOPROTEIN ; CYTOCHROME-C ; BCL-2 FAMILY ; IN-VITRO ; MITOCHONDRIA ; IDENTIFICATION ; SUPPRESSION ; EXPRESSION
英文摘要:

The recurrence of breast cancer is associated with drug-resistance of cancer stem cells (CSCs), while overexpression of cell membrane ATP-binding cassette (ABC) transporters and resistance of mitochondrial apoptosis-related proteins are responsible for the drug-resistance of CSCs. The targeting berberine liposomes were developed to modulate the resistant membrane and mitochondrial proteins of breast CSCs for the treatment and prevention of breast cancer relapse. Evaluations were performed on human breast CSCs and CSC xenografts in nude mice. The targeting berberine liposomes were shown to cross the CSC membrane, inhibit ABC transporters (ABCC1, ABCC2, ABCC3, ABCG2) and selectively accumulate in the mitochondria. Furthermore, the pro-apoptotic protein Bax was activated while the anti-apoptotic protein Bcl-2 was inhibited resulting in opening of the mitochondrial permeability transition pores, release of cytochrome c, and activation of caspase-9/caspase-3 enzymes. Significant efficacy of the administrations in mice was observed, indicating that the targeting berberine liposomes are a potential therapy for the treatment and prevention of breast cancer relapse arising from CSCs. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2013CB932501 ; 81172991 ; 7131009 ; BMU20110263
项目资助者: National Basic Research Program of China (973 program) ; National Science Foundation of China ; Beijing Natural Science Foundation ; Innovation Team of Ministry of Education
WOS记录号: WOS:000317884800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61196
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Ma, Xu,Zhou, Jia,Zhang, Cheng-Xiang,et al. Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes[J]. BIOMATERIALS,2013,34(18):4452-4465.
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