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Receptor-ligand interactions in a reconstituted bilayer lipid membrane
Wang, L; Hou, XP; Ottova, A; Tien, HT
关键词bilayer lipid membrane planar lipid bilayer receptor-ligand interactions electrical properties reconstitution
刊名ELECTROCHEMISTRY COMMUNICATIONS
2000-05-01
2期:5页:287-289
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Electrochemistry
研究领域[WOS]Electrochemistry
英文摘要

A simple method is described to reconstitute membrane receptors into bilayer Lipid membranes (BLMs). After reconstitution, the receptor still retains its ligand activity. Furthermore, the relationship between receptor-ligand interactions and electrical properties of reconstituted BLMs such as membrane capacitance (C-m) and membrane resistance (R-m) was studied. When glycophorin in erythrocyte and asialoglycoprotein in hepatocyte were taken as examples, it was found that the resistance of reconstituted BLM decreased when adding blood type monoclonal antibody or the solutions of galactose, respectively, and the decrease is ligand-concentration dependent; however, the membrane capacitance was not influenced. This provides a simple, practical approach to determining the interactions between the receptor and its ligand. (C) 2000 Published by Elsevier Science S.A. All rights reserved.

语种英语
WOS记录号WOS:000086885500001
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61199
专题北京大学药学院
作者单位1.Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
2.Beijing Med Univ, Sch Pharmaceut Sci, Dept Phys Pharm, Beijing 100083, Peoples R China
3.Slovak Univ Technol Bratislava, Fac Elect Engn & Informat Technol, Dept Microelect, Bratislava 81219, Slovakia
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GB/T 7714
Wang, L,Hou, XP,Ottova, A,et al. Receptor-ligand interactions in a reconstituted bilayer lipid membrane[J]. ELECTROCHEMISTRY COMMUNICATIONS,2000,2(5):287-289.
APA Wang, L,Hou, XP,Ottova, A,&Tien, HT.(2000).Receptor-ligand interactions in a reconstituted bilayer lipid membrane.ELECTROCHEMISTRY COMMUNICATIONS,2(5),287-289.
MLA Wang, L,et al."Receptor-ligand interactions in a reconstituted bilayer lipid membrane".ELECTROCHEMISTRY COMMUNICATIONS 2.5(2000):287-289.
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