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学科主题: 药学
题名:
Determination of nonsteroidal anti-inflammatory drugs in serum by microchip capillary electrophoresis with electrochemical detection
作者: Ding, Yongsheng; Garcia, Carlos D.
关键词: microchip ; capillary electrophoresis ; nonsteroidal anti-inflammatory drugs ; electrochemical detection
刊名: ELECTROANALYSIS
发表日期: 2006-11-01
DOI: 10.1002/elan.200603648
卷: 18, 期:22, 页:2202-2209
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Electrochemistry
研究领域[WOS]: Chemistry ; Electrochemistry
关键词[WOS]: PULSED AMPEROMETRIC DETECTION ; MICELLAR ELECTROKINETIC CHROMATOGRAPHY ; POLY(DIMETHYLSILOXANE) MICROFLUIDIC DEVICES ; INDUCED FLUORESCENCE DETECTION ; ZONE-ELECTROPHORESIS ; SURFACE MODIFICATION ; MASS-SPECTROMETRY ; ACETAMINOPHEN OVERDOSE ; ACIDIC DRUGS ; AMINO-ACIDS
英文摘要:

A simple and rapid method has been developed for the analysis of four nonsteroidal anti-inflammatory drugs (NSAIDs) in serum using microchip capillary electrophoresis with pulsed amperometric detection. The selected NSAIDs (salicylic acid, acetaminophen, diflunisal, and diclofenac) are among the most commonly used drugs to treat fever, inflammation, and pain. Used above the therapeutic levels, these drugs can cause a wide variety of adverse effects and their fast analysis could have a significant impact in treatment and recovery of the patients. Several conditions, including separation potential, pH, and concentration of the electrolyte solution were studied to optimize the separation and detection. In this study, salicylic acid, acetaminophen, diflunisal, and diclofenac were separated in less than 2 minutes using a 5 mM borate buffer at pH 11.5 and a separation potential of + 1200 V Linear relationships were obtained between the concentration and peak current in the 0.5 - 15.3 mu g/mL range and detection limits around 0.26 mu g/mL. After 30 consecutive injections, the stability of both the response and migration time of the analytes showed relative related deviations of less than 4.6% and 1.0%, respectively. The potential of this method was verified by spiking a bovine serum sample with the four NSAIDs and analyzing the recovery ratio.

语种: 英语
WOS记录号: WOS:000242412500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61204
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Univ Texas, Dept Chem, San Antonio, TX 78249 USA
2.Peking Univ, Hlth Sci Ctr, Dept Chem Biol, Beijing 100083, Peoples R China

Recommended Citation:
Ding, Yongsheng,Garcia, Carlos D.. Determination of nonsteroidal anti-inflammatory drugs in serum by microchip capillary electrophoresis with electrochemical detection[J]. ELECTROANALYSIS,2006,18(22):2202-2209.
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