IR@PKUHSC  > 北京大学药学院  > 化学生物学系
学科主题药学
Determination of nonsteroidal anti-inflammatory drugs in serum by microchip capillary electrophoresis with electrochemical detection
Ding, Yongsheng; Garcia, Carlos D.
关键词microchip capillary electrophoresis nonsteroidal anti-inflammatory drugs electrochemical detection
刊名ELECTROANALYSIS
2006-11-01
DOI10.1002/elan.200603648
18期:22页:2202-2209
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Electrochemistry
研究领域[WOS]Chemistry ; Electrochemistry
关键词[WOS]PULSED AMPEROMETRIC DETECTION ; MICELLAR ELECTROKINETIC CHROMATOGRAPHY ; POLY(DIMETHYLSILOXANE) MICROFLUIDIC DEVICES ; INDUCED FLUORESCENCE DETECTION ; ZONE-ELECTROPHORESIS ; SURFACE MODIFICATION ; MASS-SPECTROMETRY ; ACETAMINOPHEN OVERDOSE ; ACIDIC DRUGS ; AMINO-ACIDS
英文摘要

A simple and rapid method has been developed for the analysis of four nonsteroidal anti-inflammatory drugs (NSAIDs) in serum using microchip capillary electrophoresis with pulsed amperometric detection. The selected NSAIDs (salicylic acid, acetaminophen, diflunisal, and diclofenac) are among the most commonly used drugs to treat fever, inflammation, and pain. Used above the therapeutic levels, these drugs can cause a wide variety of adverse effects and their fast analysis could have a significant impact in treatment and recovery of the patients. Several conditions, including separation potential, pH, and concentration of the electrolyte solution were studied to optimize the separation and detection. In this study, salicylic acid, acetaminophen, diflunisal, and diclofenac were separated in less than 2 minutes using a 5 mM borate buffer at pH 11.5 and a separation potential of + 1200 V Linear relationships were obtained between the concentration and peak current in the 0.5 - 15.3 mu g/mL range and detection limits around 0.26 mu g/mL. After 30 consecutive injections, the stability of both the response and migration time of the analytes showed relative related deviations of less than 4.6% and 1.0%, respectively. The potential of this method was verified by spiking a bovine serum sample with the four NSAIDs and analyzing the recovery ratio.

语种英语
WOS记录号WOS:000242412500007
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61204
专题北京大学药学院_化学生物学系
作者单位1.Univ Texas, Dept Chem, San Antonio, TX 78249 USA
2.Peking Univ, Hlth Sci Ctr, Dept Chem Biol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ding, Yongsheng,Garcia, Carlos D.. Determination of nonsteroidal anti-inflammatory drugs in serum by microchip capillary electrophoresis with electrochemical detection[J]. ELECTROANALYSIS,2006,18(22):2202-2209.
APA Ding, Yongsheng,&Garcia, Carlos D..(2006).Determination of nonsteroidal anti-inflammatory drugs in serum by microchip capillary electrophoresis with electrochemical detection.ELECTROANALYSIS,18(22),2202-2209.
MLA Ding, Yongsheng,et al."Determination of nonsteroidal anti-inflammatory drugs in serum by microchip capillary electrophoresis with electrochemical detection".ELECTROANALYSIS 18.22(2006):2202-2209.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ding, Yongsheng]的文章
[Garcia, Carlos D.]的文章
百度学术
百度学术中相似的文章
[Ding, Yongsheng]的文章
[Garcia, Carlos D.]的文章
必应学术
必应学术中相似的文章
[Ding, Yongsheng]的文章
[Garcia, Carlos D.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。