IR@PKUHSC  > 北京大学药学院
学科主题药学
Modulation of Colon Cancer by Nutmeg
Li, Fei1,2; Yang, Xiu-Wei3; Krausz, Kristopher W.1; Nichols, Robert G.4; Xu, Wei3; Patterson, Andrew D.4; Gonzalez, Frank J.1
关键词Colon cancer nutmeg uremic toxin inflammation metabolomics mass spectrometry
刊名JOURNAL OF PROTEOME RESEARCH
2015-04-01
DOI10.1021/pr5013152
14期:4页:1937-1946
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods
资助者U.S.-China Program for Biomedical Collaborative Research ; National Cancer Institute Intramural Research Program ; National Natural Science Foundation of China ; U.S.-China Program for Biomedical Collaborative Research ; National Cancer Institute Intramural Research Program ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]INFLAMMATORY-BOWEL-DISEASE ; HUMAN COLORECTAL-CANCER ; MYRISTICA-FRAGRANS ; HELICOBACTER-PYLORI ; MASS-SPECTROMETRY ; UREMIC TOXINS ; INDOXYL SULFATE ; METABOLOMICS ; MICE ; METABOLISM
英文摘要

Colon cancer is the most common cancer and the third leading cause of cancer mortality in humans. Using mass spectrometry-based metabolomics, the current study revealed the accumulation of four uremic toxins (cresol sulfate, cresol glucuronide, indoxyl sulfate, and phenyl sulfate) in the serum of mice harboring adenomatous polyposis coli (APC) gene mutation-induced colon cancer. These uremic toxins, likely generated from the gut microbiota, were associated with an increase in the expression of the proinflammatory cytokine IL-6 and a disorder of lipid metabolism. Nutmeg, which exhibits antimicrobial activity, attenuated the levels of uremic toxins and decreased intestinal tumorigenesis in Apc(min/+) mice. Nutmeg-treated Apc(min/+) mice had decreased IL-6 levels and normalized dysregulated lipid metabolism, suggesting that uremic toxins are responsible, in part, for the metabolic disorders that occur during tumorigenesis. These studies demonstrate a potential biochemical link among gut microbial metabolism, inflammation, and metabolic disorders and suggest that modulation of gut microbiota and lipid metabolism using dietary intervention or drugs may be effective in colon cancer chemoprevention strategies.

语种英语
所属项目编号30973863 ; 81161120429 ; 81360509
资助者U.S.-China Program for Biomedical Collaborative Research ; National Cancer Institute Intramural Research Program ; National Natural Science Foundation of China ; U.S.-China Program for Biomedical Collaborative Research ; National Cancer Institute Intramural Research Program ; National Natural Science Foundation of China
WOS记录号WOS:000352463300026
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61207
专题北京大学药学院
作者单位1.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
2.Jiangxi Univ Tradit Chinese Med, Res Ctr Differentiat & Dev Basic Theory Tradit Ch, Nanchang 330004, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs,Dept Nat Med, Beijing 100191, Peoples R China
4.Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA
推荐引用方式
GB/T 7714
Li, Fei,Yang, Xiu-Wei,Krausz, Kristopher W.,et al. Modulation of Colon Cancer by Nutmeg[J]. JOURNAL OF PROTEOME RESEARCH,2015,14(4):1937-1946.
APA Li, Fei.,Yang, Xiu-Wei.,Krausz, Kristopher W..,Nichols, Robert G..,Xu, Wei.,...&Gonzalez, Frank J..(2015).Modulation of Colon Cancer by Nutmeg.JOURNAL OF PROTEOME RESEARCH,14(4),1937-1946.
MLA Li, Fei,et al."Modulation of Colon Cancer by Nutmeg".JOURNAL OF PROTEOME RESEARCH 14.4(2015):1937-1946.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Fei]的文章
[Yang, Xiu-Wei]的文章
[Krausz, Kristopher W.]的文章
百度学术
百度学术中相似的文章
[Li, Fei]的文章
[Yang, Xiu-Wei]的文章
[Krausz, Kristopher W.]的文章
必应学术
必应学术中相似的文章
[Li, Fei]的文章
[Yang, Xiu-Wei]的文章
[Krausz, Kristopher W.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。