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学科主题: 药学
题名:
Modulation of Colon Cancer by Nutmeg
作者: Li, Fei1,2; Yang, Xiu-Wei3; Krausz, Kristopher W.1; Nichols, Robert G.4; Xu, Wei3; Patterson, Andrew D.4; Gonzalez, Frank J.1
关键词: Colon cancer ; nutmeg uremic toxin ; inflammation ; metabolomics ; mass spectrometry
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2015-04-01
DOI: 10.1021/pr5013152
卷: 14, 期:4, 页:1937-1946
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: INFLAMMATORY-BOWEL-DISEASE ; HUMAN COLORECTAL-CANCER ; MYRISTICA-FRAGRANS ; HELICOBACTER-PYLORI ; MASS-SPECTROMETRY ; UREMIC TOXINS ; INDOXYL SULFATE ; METABOLOMICS ; MICE ; METABOLISM
英文摘要:

Colon cancer is the most common cancer and the third leading cause of cancer mortality in humans. Using mass spectrometry-based metabolomics, the current study revealed the accumulation of four uremic toxins (cresol sulfate, cresol glucuronide, indoxyl sulfate, and phenyl sulfate) in the serum of mice harboring adenomatous polyposis coli (APC) gene mutation-induced colon cancer. These uremic toxins, likely generated from the gut microbiota, were associated with an increase in the expression of the proinflammatory cytokine IL-6 and a disorder of lipid metabolism. Nutmeg, which exhibits antimicrobial activity, attenuated the levels of uremic toxins and decreased intestinal tumorigenesis in Apc(min/+) mice. Nutmeg-treated Apc(min/+) mice had decreased IL-6 levels and normalized dysregulated lipid metabolism, suggesting that uremic toxins are responsible, in part, for the metabolic disorders that occur during tumorigenesis. These studies demonstrate a potential biochemical link among gut microbial metabolism, inflammation, and metabolic disorders and suggest that modulation of gut microbiota and lipid metabolism using dietary intervention or drugs may be effective in colon cancer chemoprevention strategies.

语种: 英语
所属项目编号: 30973863 ; 81161120429 ; 81360509
项目资助者: U.S.-China Program for Biomedical Collaborative Research ; National Cancer Institute Intramural Research Program ; National Natural Science Foundation of China
WOS记录号: WOS:000352463300026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61207
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
2.Jiangxi Univ Tradit Chinese Med, Res Ctr Differentiat & Dev Basic Theory Tradit Ch, Nanchang 330004, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs,Dept Nat Med, Beijing 100191, Peoples R China
4.Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA

Recommended Citation:
Li, Fei,Yang, Xiu-Wei,Krausz, Kristopher W.,et al. Modulation of Colon Cancer by Nutmeg[J]. JOURNAL OF PROTEOME RESEARCH,2015,14(4):1937-1946.
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