IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Suppression of cue-induced heroin craving and cue-reactivity by single-trial transcutaneous electrical nerve stimulation at 2 Hz
Zhong, Fei; Wu, Liu-Zhen; Han, Ji-Sheng
关键词cue reactivity drug-related cue heroin craving heroin dependence relapse transcutaneous electrical nerve stimulation
刊名ADDICTION BIOLOGY
2006-06-01
DOI10.1111/j.1355-6215.2006.00020.x
11期:2页:184-189
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Substance Abuse
研究领域[WOS]Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]DETOXIFIED OPIATE ADDICTS ; MOLECULAR-MECHANISMS ; COCAINE ; EXPOSURE ; RELAPSE ; SEEKING
英文摘要

The purpose of the present study was to investigate the efficacy of 2 Hz transcutaneous electrical nerve stimulation (TENS) to reduce cue-induced heroin craving and the corresponding cardiovascular responses. Seventy heroin addicts with at least 1 month of abstinence were enrolled and randomly divided into two groups of 35, to receive single-trial 2 Hz TENS (TENS group) or mock TENS (mock group) during experimental procedure, respectively. They were required to express their degree of craving by visual analog scale before and after the presentation of a video-cue, and after TENS treatment, which lasted for 30 minutes. Heart rate and arterial blood pressure were simultaneously monitored in 56 cases, with 28 in each group. Results show that in mock group, video-cue induced a dramatic increase of craving score, which did not return to baseline in 150 minutes, whereas in the TENS group, 2 Hz TENS treatment produced a significant decrease of craving, reaching baseline in 90 minutes. Video-cue induced a significant increase of heart rate and systolic and diastolic blood pressure, which remained elevated for at least 60 minutes in the mock group; whereas in the TENS group, they returned to baseline immediately after the termination of TENS. These results indicate that the craving induced by a heroin-related cue can be immediately and significantly suppressed, and the cardiovascular activation totally abolished by a single-trial 2 Hz TENS for 30 minutes.

语种英语
WOS记录号WOS:000238484700010
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61211
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Dept Neurol, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhong, Fei,Wu, Liu-Zhen,Han, Ji-Sheng. Suppression of cue-induced heroin craving and cue-reactivity by single-trial transcutaneous electrical nerve stimulation at 2 Hz[J]. ADDICTION BIOLOGY,2006,11(2):184-189.
APA Zhong, Fei,Wu, Liu-Zhen,&Han, Ji-Sheng.(2006).Suppression of cue-induced heroin craving and cue-reactivity by single-trial transcutaneous electrical nerve stimulation at 2 Hz.ADDICTION BIOLOGY,11(2),184-189.
MLA Zhong, Fei,et al."Suppression of cue-induced heroin craving and cue-reactivity by single-trial transcutaneous electrical nerve stimulation at 2 Hz".ADDICTION BIOLOGY 11.2(2006):184-189.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Suppression of cue-i(154KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhong, Fei]的文章
[Wu, Liu-Zhen]的文章
[Han, Ji-Sheng]的文章
百度学术
百度学术中相似的文章
[Zhong, Fei]的文章
[Wu, Liu-Zhen]的文章
[Han, Ji-Sheng]的文章
必应学术
必应学术中相似的文章
[Zhong, Fei]的文章
[Wu, Liu-Zhen]的文章
[Han, Ji-Sheng]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Suppression of cue-induced heroin craving and cue-reactivity by single-trial transcutaneous electrical nerve stimulation at 2 Hz.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。