IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Can Antidepressants Prevent Pegylated Interferon-alpha/Ribavirin-Associated Depression in Patients with Chronic Hepatitis C: Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials?
Hou, Xin-Jiang; Xu, Jing-Hang; Wang, Jun; Yu, Yan-Yan
刊名PLOS ONE
2013-10-30
DOI10.1371/journal.pone.0076799
8期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ALPHA-INDUCED DEPRESSION ; PLUS RIBAVIRIN ; PEGINTERFERON ALPHA-2A ; VIROLOGICAL RESPONSE ; SUSTAINED RESPONSE ; MAJOR DEPRESSION ; VIRUS-INFECTION ; THERAPY ; CITALOPRAM ; SYMPTOMS
英文摘要

Background: Antidepressants are effective in treating interferon-alpha/ribavirin (IFN-alpha/RBV)-associated depression during or after treatment of chronic hepatitis C (CHC). Whether antidepressant prophylaxis is necessary in this population remains under debate.

Methods: Comprehensive searches were performed in Medline, Embase, Cochrane Controlled Trials Register and PubMed. Reference lists were searched manually. The methodology was in accordance with the 2009 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) Statement.

Results: We identified six randomized, double-blind, placebo-controlled trials involving 522 CHC patients treated with pegylated (PEG)-IFN-alpha plus RBV. The antidepressants used were escitalopram, citalopram, and paroxetine, which are selective serotonin reuptake inhibitors (SSRIs). The rates of depression (17.9% vs. 31.0%, P = 0.0005), and rescue therapy (27.4% vs. 42.7%, P<0.0001) in the SSRI group were significantly lower than those in the placebo group. The rate of sustained virological response (SVR) (56.8% vs. 50.0%, P = 0.60) and drug discontinuation (18.7% vs. 21.1%, P = 0.63) in the SSRI group did not differ significantly to those in the placebo group. In terms of safety, the incidence of muscle and joint pain (40.8% vs. 52.4%, P = 0.03) and respiratory problems (29.3% vs. 40.1%, P = 0.03) were lower, but the incidence of dizziness was significantly higher (22.3% vs. 10.2%, P = 0.001) in the SSRI group.

Conclusion: Prophylactic SSRI antidepressants can significantly reduce the incidence of PEG-IFN-alpha/RBV-associated depression in patients with CHC, with good safety and tolerability, without reduction of SVR.

语种英语
WOS记录号WOS:000326334500010
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61212
专题北京大学第一临床医学院_感染疾病科
作者单位Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Hou, Xin-Jiang,Xu, Jing-Hang,Wang, Jun,et al. Can Antidepressants Prevent Pegylated Interferon-alpha/Ribavirin-Associated Depression in Patients with Chronic Hepatitis C: Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials?[J]. PLOS ONE,2013,8(10).
APA Hou, Xin-Jiang,Xu, Jing-Hang,Wang, Jun,&Yu, Yan-Yan.(2013).Can Antidepressants Prevent Pegylated Interferon-alpha/Ribavirin-Associated Depression in Patients with Chronic Hepatitis C: Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials?.PLOS ONE,8(10).
MLA Hou, Xin-Jiang,et al."Can Antidepressants Prevent Pegylated Interferon-alpha/Ribavirin-Associated Depression in Patients with Chronic Hepatitis C: Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials?".PLOS ONE 8.10(2013).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hou, Xin-Jiang]的文章
[Xu, Jing-Hang]的文章
[Wang, Jun]的文章
百度学术
百度学术中相似的文章
[Hou, Xin-Jiang]的文章
[Xu, Jing-Hang]的文章
[Wang, Jun]的文章
必应学术
必应学术中相似的文章
[Hou, Xin-Jiang]的文章
[Xu, Jing-Hang]的文章
[Wang, Jun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。