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IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科  > 期刊论文
学科主题: 临床医学
题名:
Can Antidepressants Prevent Pegylated Interferon-alpha/Ribavirin-Associated Depression in Patients with Chronic Hepatitis C: Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials?
作者: Hou, Xin-Jiang; Xu, Jing-Hang; Wang, Jun; Yu, Yan-Yan
刊名: PLOS ONE
发表日期: 2013-10-30
DOI: 10.1371/journal.pone.0076799
卷: 8, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ALPHA-INDUCED DEPRESSION ; PLUS RIBAVIRIN ; PEGINTERFERON ALPHA-2A ; VIROLOGICAL RESPONSE ; SUSTAINED RESPONSE ; MAJOR DEPRESSION ; VIRUS-INFECTION ; THERAPY ; CITALOPRAM ; SYMPTOMS
英文摘要:

Background: Antidepressants are effective in treating interferon-alpha/ribavirin (IFN-alpha/RBV)-associated depression during or after treatment of chronic hepatitis C (CHC). Whether antidepressant prophylaxis is necessary in this population remains under debate.

Methods: Comprehensive searches were performed in Medline, Embase, Cochrane Controlled Trials Register and PubMed. Reference lists were searched manually. The methodology was in accordance with the 2009 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) Statement.

Results: We identified six randomized, double-blind, placebo-controlled trials involving 522 CHC patients treated with pegylated (PEG)-IFN-alpha plus RBV. The antidepressants used were escitalopram, citalopram, and paroxetine, which are selective serotonin reuptake inhibitors (SSRIs). The rates of depression (17.9% vs. 31.0%, P = 0.0005), and rescue therapy (27.4% vs. 42.7%, P<0.0001) in the SSRI group were significantly lower than those in the placebo group. The rate of sustained virological response (SVR) (56.8% vs. 50.0%, P = 0.60) and drug discontinuation (18.7% vs. 21.1%, P = 0.63) in the SSRI group did not differ significantly to those in the placebo group. In terms of safety, the incidence of muscle and joint pain (40.8% vs. 52.4%, P = 0.03) and respiratory problems (29.3% vs. 40.1%, P = 0.03) were lower, but the incidence of dizziness was significantly higher (22.3% vs. 10.2%, P = 0.001) in the SSRI group.

Conclusion: Prophylactic SSRI antidepressants can significantly reduce the incidence of PEG-IFN-alpha/RBV-associated depression in patients with CHC, with good safety and tolerability, without reduction of SVR.

语种: 英语
WOS记录号: WOS:000326334500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61212
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100871, Peoples R China

Recommended Citation:
Hou, Xin-Jiang,Xu, Jing-Hang,Wang, Jun,et al. Can Antidepressants Prevent Pegylated Interferon-alpha/Ribavirin-Associated Depression in Patients with Chronic Hepatitis C: Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials?[J]. PLOS ONE,2013,8(10).
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