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学科主题: 临床医学
题名:
Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression
作者: Shao, Yimin; Yuan, Geheng; Zhang, Junqing; Guo, Xiaohui
关键词: liraglutide ; visceral adipose tissue ; AMP-activated protein kinase ; lipogenesis
刊名: DRUG DESIGN DEVELOPMENT AND THERAPY
发表日期: 2015
DOI: 10.2147/DDDT.S79175
卷: 9, 页:1177-1184
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: GLUCAGON-LIKE PEPTIDE-1 ; PROTEIN-KINASE ; INSULIN-RESISTANCE ; ADIPOCYTE DIFFERENTIATION ; OBESITY ; FAT ; METFORMIN ; SAFETY ; COMBINATION ; EFFICACY
英文摘要:

Liraglutide, a glucagon-like peptide-1 analog, has been proved to reduce body weight and visceral adipose tissue (VAT) in human studies. In this study, we aimed at examining lipogenetic signal changes in VAT after weight-loss with liraglutide in db/db mice. The mice were divided into two groups: liraglutide-treated group (n=14, 8-week-old, fasting glucose. >10 mmol/L, liraglutide 300 mu g/kg twice a day for 4 weeks) and control group (n=14, saline). We found body weight gain and food intake were reduced after liraglutide treatment (P<0.05). Compared to the control group, the VAT weights were significantly lower in the treated group (2.32 +/- 0.37 g versus 3.20 +/- 0.30 g, P<0.01) than that in control group. In VAT, compared with control group, the lipogenetic transcription factors PPAR gamma and C/EBP alpha expressions were both reduced with pAMPK and pACC increased 3.5-fold and 2.31-fold respectively, while pAkt and pP38MAPK were reduced 0.38-fold and 0.62-fold respectively (P<0.01). In conclusion, VAT was reduced after weight loss with AMPK activation and Akt suppression with liraglutide treatment, which was associated with reduction of lipogenetic process in VAT.

语种: 英语
WOS记录号: WOS:000349529900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61214
Appears in Collections:北京大学第一临床医学院_内分泌内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China

Recommended Citation:
Shao, Yimin,Yuan, Geheng,Zhang, Junqing,et al. Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression[J]. DRUG DESIGN DEVELOPMENT AND THERAPY,2015,9:1177-1184.
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