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学科主题临床医学
Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression
Shao, Yimin; Yuan, Geheng; Zhang, Junqing; Guo, Xiaohui
关键词liraglutide visceral adipose tissue AMP-activated protein kinase lipogenesis
刊名DRUG DESIGN DEVELOPMENT AND THERAPY
2015
DOI10.2147/DDDT.S79175
9页:1177-1184
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]GLUCAGON-LIKE PEPTIDE-1 ; PROTEIN-KINASE ; INSULIN-RESISTANCE ; ADIPOCYTE DIFFERENTIATION ; OBESITY ; FAT ; METFORMIN ; SAFETY ; COMBINATION ; EFFICACY
英文摘要

Liraglutide, a glucagon-like peptide-1 analog, has been proved to reduce body weight and visceral adipose tissue (VAT) in human studies. In this study, we aimed at examining lipogenetic signal changes in VAT after weight-loss with liraglutide in db/db mice. The mice were divided into two groups: liraglutide-treated group (n=14, 8-week-old, fasting glucose. >10 mmol/L, liraglutide 300 mu g/kg twice a day for 4 weeks) and control group (n=14, saline). We found body weight gain and food intake were reduced after liraglutide treatment (P<0.05). Compared to the control group, the VAT weights were significantly lower in the treated group (2.32 +/- 0.37 g versus 3.20 +/- 0.30 g, P<0.01) than that in control group. In VAT, compared with control group, the lipogenetic transcription factors PPAR gamma and C/EBP alpha expressions were both reduced with pAMPK and pACC increased 3.5-fold and 2.31-fold respectively, while pAkt and pP38MAPK were reduced 0.38-fold and 0.62-fold respectively (P<0.01). In conclusion, VAT was reduced after weight loss with AMPK activation and Akt suppression with liraglutide treatment, which was associated with reduction of lipogenetic process in VAT.

语种英语
WOS记录号WOS:000349529900001
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61214
专题北京大学第一临床医学院_内分泌内科
作者单位Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
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Shao, Yimin,Yuan, Geheng,Zhang, Junqing,et al. Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression[J]. DRUG DESIGN DEVELOPMENT AND THERAPY,2015,9:1177-1184.
APA Shao, Yimin,Yuan, Geheng,Zhang, Junqing,&Guo, Xiaohui.(2015).Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression.DRUG DESIGN DEVELOPMENT AND THERAPY,9,1177-1184.
MLA Shao, Yimin,et al."Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression".DRUG DESIGN DEVELOPMENT AND THERAPY 9(2015):1177-1184.
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