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学科主题基础医学
Stress or drug priming induces reinstatement of extinguished conditioned place preference
Wang, B; Luo, F; Zhang, WT; Han, JS
关键词amphetamine conditioned place preference extinction morphine opioid addiction psychological dependence reinstatement relapse stress
刊名NEUROREPORT
2000-08-21
11期:12页:2781-2784
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]2ND-ORDER SCHEDULE ; HEROIN-SEEKING ; RATS ; REINFORCEMENT ; COCAINE ; RELAPSE ; ANTAGONISTS ; WITHDRAWAL ; ADDICTION
英文摘要

To construct a model for the relapse of drug use, we investigated the reinstatement of morphine-induced conditioned place preference (CPP) in rats. After the morphine CPP paradigm was established, rats were left extinguishing for 9 days, then exposed to 15 min of random foot shock or s.c. drug priming with different doses of morphine or amphetamine, respectively. Foot shock or a higher dose (0.25 mg/kg) of both drugs could reinstate the CPP induced by 4 mg/kg of morphine after a 9-day extinction, while a lower dose (0.125 mg/kg) of both drugs had no effect. It is concluded that the CPP extinction-reinstatement paradigm might be used as a model to investigate the mechanism of relapse in addicts. Neuroreport 11:2781-2784 (C) Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000089003300042
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被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61218
专题北京大学基础医学院_神经生物学系
作者单位Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
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GB/T 7714
Wang, B,Luo, F,Zhang, WT,et al. Stress or drug priming induces reinstatement of extinguished conditioned place preference[J]. NEUROREPORT,2000,11(12):2781-2784.
APA Wang, B,Luo, F,Zhang, WT,&Han, JS.(2000).Stress or drug priming induces reinstatement of extinguished conditioned place preference.NEUROREPORT,11(12),2781-2784.
MLA Wang, B,et al."Stress or drug priming induces reinstatement of extinguished conditioned place preference".NEUROREPORT 11.12(2000):2781-2784.
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