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学科主题: 基础医学
题名:
Stress or drug priming induces reinstatement of extinguished conditioned place preference
作者: Wang, B; Luo, F; Zhang, WT; Han, JS
关键词: amphetamine ; conditioned place preference ; extinction ; morphine ; opioid addiction ; psychological dependence ; reinstatement ; relapse ; stress
刊名: NEUROREPORT
发表日期: 2000-08-21
卷: 11, 期:12, 页:2781-2784
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: 2ND-ORDER SCHEDULE ; HEROIN-SEEKING ; RATS ; REINFORCEMENT ; COCAINE ; RELAPSE ; ANTAGONISTS ; WITHDRAWAL ; ADDICTION
英文摘要:

To construct a model for the relapse of drug use, we investigated the reinstatement of morphine-induced conditioned place preference (CPP) in rats. After the morphine CPP paradigm was established, rats were left extinguishing for 9 days, then exposed to 15 min of random foot shock or s.c. drug priming with different doses of morphine or amphetamine, respectively. Foot shock or a higher dose (0.25 mg/kg) of both drugs could reinstate the CPP induced by 4 mg/kg of morphine after a 9-day extinction, while a lower dose (0.125 mg/kg) of both drugs had no effect. It is concluded that the CPP extinction-reinstatement paradigm might be used as a model to investigate the mechanism of relapse in addicts. Neuroreport 11:2781-2784 (C) Lippincott Williams & Wilkins.

语种: 英语
WOS记录号: WOS:000089003300042
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61218
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Wang, B,Luo, F,Zhang, WT,et al. Stress or drug priming induces reinstatement of extinguished conditioned place preference[J]. NEUROREPORT,2000,11(12):2781-2784.
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