IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions
Wang, Hua1,2; Liu, Congrong1,2; Debnath, Gargi1; Baines, Anthony J.4; Conboy, John G.5; Mohandas, Narla1; An, Xiuli1,3
关键词4 1R 4 1G 4 1B 4 1N Adrenal gland
刊名HISTOCHEMISTRY AND CELL BIOLOGY
2010-10-01
DOI10.1007/s00418-010-0749-z
134期:4页:411-420
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Microscopy
研究领域[WOS]Cell Biology ; Microscopy
关键词[WOS]ACTIN-BINDING DOMAIN ; CELL MEMBRANE ; GENE FAMILY ; CYTOSKELETAL ; COMPLEX ; ISOFORMS ; MECHANOCHEMISTRY ; EVOLUTION ; INTEGRITY ; JUNCTION
英文摘要

The members of the protein 4.1 family, 4.1R, 4.1G, 4.1N, and 4.1B, are encoded by four genes, all of which undergo complex alternative splicing. It is well established that 4.1R, the prototypical member of the family, serves as an adapter that links the spectrin-actin based cytoskeleton to the plasma membrane in red cells. It is required for mechanical resilience of the membrane, and it ensures the cell surface accumulation of selected membrane proteins. However, the function of 4.1 proteins outside erythrocytes remains under-explored, especially in endocrine tissues. Transcripts of all 4.1 homologs have previously been documented to be abundantly expressed in adrenal gland. In order to begin to decipher the function of 4.1 proteins in adrenal gland, we performed a detailed characterization of the expression pattern of various 4.1 proteins and their cellular localization. We show that 4.1R (similar to 80 and similar to 135 kDa) splice forms are expressed on the membrane of all cells, while a similar to 160 kDa 4.1G splice form is distributed in the cytoplasm and the membrane of zona glomerulosa and of medullary cells. Two 4.1N splice forms, similar to 135 and similar to 95 kDa, are present in the peri-nuclear region of both zona glomerulosa and medullary cells, while a single similar to 130 kDa 4.1B splice form, is detected in all layers of adrenal gland in both the cytoplasm and the membrane. The characterization of distinct splice forms of various 4.1 proteins with diverse cellular and sub-cellular localization indicates multiple functions for this family of proteins in endocrine functions of adrenal gland.

语种英语
WOS记录号WOS:000282974600010
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61219
专题北京大学基础医学院_病理学系
北京大学基础医学院
作者单位1.New York Blood Ctr, Red Cell Physiol Lab, New York, NY 10065 USA
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100191, Peoples R China
4.Univ Kent, Sch Biosci, Canterbury CT2 7NJ, Kent, England
5.Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
推荐引用方式
GB/T 7714
Wang, Hua,Liu, Congrong,Debnath, Gargi,et al. Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions[J]. HISTOCHEMISTRY AND CELL BIOLOGY,2010,134(4):411-420.
APA Wang, Hua.,Liu, Congrong.,Debnath, Gargi.,Baines, Anthony J..,Conboy, John G..,...&An, Xiuli.(2010).Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions.HISTOCHEMISTRY AND CELL BIOLOGY,134(4),411-420.
MLA Wang, Hua,et al."Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions".HISTOCHEMISTRY AND CELL BIOLOGY 134.4(2010):411-420.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Comprehensive charac(1062KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Hua]的文章
[Liu, Congrong]的文章
[Debnath, Gargi]的文章
百度学术
百度学术中相似的文章
[Wang, Hua]的文章
[Liu, Congrong]的文章
[Debnath, Gargi]的文章
必应学术
必应学术中相似的文章
[Wang, Hua]的文章
[Liu, Congrong]的文章
[Debnath, Gargi]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland implications for functions.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。