IR@PKUHSC  > 北京大学药学院
学科主题药学
Studies on pharmacokinetics and tissue distribution of bifendate nanosuspensions for intravenous delivery
Liu, Yue1; Zhang, Dianrui1; Duan, Cunxian1; Jia, Lejiao1; Xie, Pengcheng2; Zheng, Dandan1; Wang, Feihu1; Liu, Guangpu1; Hao, Leilei1; Zhang, Xueshun3; Zhang, Qiang4
关键词nanosuspensions DDB precipitation-combined microfluidization method pharmacokinetics tissue distribution
刊名JOURNAL OF MICROENCAPSULATION
2012
DOI10.3109/02652048.2011.642015
29期:2页:194-203
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
资助者National Basic Research Program of China (973Program) ; National Basic Research Program of China (973Program)
研究领域[WOS]Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]DRUG-DELIVERY ; VIVO EVALUATION ; NANOPARTICLES ; MICE
英文摘要

It is reported that the nanosuspension is one of the promising formulations for poorly water-soluble drugs. In order to enhance the in vitro and in vivo behaviours of DDB (bifendate), DDB-NSP (DDB nanosuspensions) have been produced by the precipitation-combined microfluidization method. The optimized DDB-NSP were transformed into dry powders by freeze-drying and then investigated by transmission electron microscopy, laser diffraction and X-ray diffraction (XRD) experiments. Next, the pharmacokinetics and biodistribution of DDB-NSP and DDB-Sol (DDB solution) were carried out. XRD experiments manifested that the crystalline state of DDB was preserved after the size reduction process. An accelerated dissolution velocity and increased saturation solubility could be shown for the DDB-NSP. Compared with DDB-Sol, DDB-NSP exhibited a markedly different pharmacokinetic property with a 17.18-fold increase in AUC(0-infinity). Meanwhile, the tissue distribution demonstrated that DDB-NSP were mainly uptaken by RES organs particularly by liver. These results supported the fact that nanosuspension, as a promising intravenous drug-delivery system for DDB, could be developed as an alternative to the conventional DDB preparations.

语种英语
所属项目编号2009CB930300
资助者National Basic Research Program of China (973Program) ; National Basic Research Program of China (973Program)
WOS记录号WOS:000300261600010
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61220
Collection北京大学药学院
作者单位1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Peoples R China
2.Jinan Petrochem Engn Design Inst, Jinan 250100, Peoples R China
3.Shandong Prov Hosipital TCM, Dept Pharmaceut, Jinan 250012, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yue,Zhang, Dianrui,Duan, Cunxian,et al. Studies on pharmacokinetics and tissue distribution of bifendate nanosuspensions for intravenous delivery[J]. JOURNAL OF MICROENCAPSULATION,2012,29(2):194-203.
APA Liu, Yue.,Zhang, Dianrui.,Duan, Cunxian.,Jia, Lejiao.,Xie, Pengcheng.,...&Zhang, Qiang.(2012).Studies on pharmacokinetics and tissue distribution of bifendate nanosuspensions for intravenous delivery.JOURNAL OF MICROENCAPSULATION,29(2),194-203.
MLA Liu, Yue,et al."Studies on pharmacokinetics and tissue distribution of bifendate nanosuspensions for intravenous delivery".JOURNAL OF MICROENCAPSULATION 29.2(2012):194-203.
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