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学科主题: 临床医学
题名:
Epigenetic inactivation of PCDH10 in human prostate cancer cell lines
作者: Li, Zesong1,2; Li, Wenjie1,3; Xie, Jun1; Wang, Yong1; Tang, Aifa1,2; Li, Xianxin1; Ye, Jiongxian1; Gui, Yaoting1; Cai, Zhiming1,2
关键词: epigenetics ; PCDH10 ; promoter methylation ; prostate cancer
刊名: CELL BIOLOGY INTERNATIONAL
发表日期: 2011-07-01
DOI: 10.1042/CBI20100568
卷: 35, 期:7, 页:671-676
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: PROTOCADHERIN PCDH10 ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; METHYLATION ; FREQUENT ; PROGRESSION ; MULTIPLE ; GROWTH
英文摘要:

PCDH10 (protocadherin-10), a novel tumour suppressor gene, is down-regulated in several human cancers due to hypermethylation of promoter CGIs (CpG islands). Here, we investigated the expression of PCDH10 in different normal adult tissues and in a panel of prostate cancer cell lines. PCDH10 was widely expressed in normal tissues with higher levels in the prostate. The expression of PCDH10 was markedly reduced or silenced in prostate cancer cell lines compared with normal adult prostate tissue. Decreased PCDH10 expression was correlated with the methylation status of the PCDH10 promoter. Furthermore, the DNA demethylating agent 5′-azacytidin restored PCDH10 expression by suppressing PCDH10 promoter methylation in prostate cancer cell lines. Treatment with Trichostatin A alone had no significant effect on the expression of PCDH10 but enhanced the effect of 5′-azacytidin. In conclusion, we found that the decreased PCDH10 expression in prostate cancer cells was associated with the aberrant methylation of PCDH10 promoter CGI. Our results may contribute to the understanding of the role of PCDH10 inactivation in the progression of prostate cancers.

语种: 英语
所属项目编号: 200800010106 ; A2010548 ; CXC201005260001A
项目资助者: Research Fund for the Doctoral Program of Higher Education of China ; Medical Scientific Research Foundation of Guangdong Province, People&prime ; s Republic of China ; Scientific Research Foundation of the State Human Resource Ministry for Returned Chinese Scholars, People&prime ; s Republic of China ; Science Foundation of Shenzhen, People&prime ; s Republic of China
WOS记录号: WOS:000293990800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61222
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Shantou 515041, Peoples R China
2.Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen PKU HKUST Med Ctr, Shenzhen 518036, Peoples R China
3.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Peoples R China

Recommended Citation:
Li, Zesong,Li, Wenjie,Xie, Jun,et al. Epigenetic inactivation of PCDH10 in human prostate cancer cell lines[J]. CELL BIOLOGY INTERNATIONAL,2011,35(7):671-676.
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