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学科主题: 临床医学
题名:
Two-stage analysis of pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese patients
作者: Zhao Yan2; Duan Jing-li3; Wu Xin-min1; Jiang Jian-yu2; Lu Wei4; Zhang Li-ping2; Wang Jun2; Meng Xiu-li2; Xu Chuan-ya2; Jia Dong-lin2; Liu Wei3; Sheng Xiao-yan3
关键词: anesthesia ; sufentanil ; pharmacokinetics ; target-controlled infusion ; two-stage analysis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2009-09-05
DOI: 10.3760/cmaj.issn.0366-6999.2009.17.004
卷: 122, 期:17, 页:1979-1984
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SURGICAL-PATIENTS ; OBESE PATIENTS ; HUMAN PLASMA ; SURGERY ; PROPOFOL ; ANESTHESIA ; ADULTS ; TRIAL ; TIME
英文摘要:

Background Sufentanil is a suitable choice for target-controlled infusion (TCI) because of its shorter context-sensitive half-time. The current study was to estimate the pharmacokinetics of sufentanil TCI in Chinese patients using the two-stage analysis.

Methods Twelve adult patients with American Society of Anesthesiologists (ASA) physical status I or II undergoing elective surgery under general anesthesia were included. Anesthesia was induced with propofol, rocuronium and sufentanil administered by TCI lasting for 30 minutes, with target effect-site concentration of sufentanil 4 or 6 ng/ml. Frequent arterial blood samples (1.5 ml) were taken during and up to 24 hours after sufentanil TCI. Before the end of surgery, another arterial blood sample (1.0 ml) was drawn for the blood-gas analysis. Plasma sufentanil concentrations were determined by liquid chromatography-tandem mass spectrometry (limit of quantitation was 5 pg/ml). The data were analyzed with the two-stage approach, linear regression and correlation analysis.

Results The pharmacokinetics of sufentanil TCI were adequately described by a three-compartment model. The variables were derived as follows: the volume of central compartment (V(1)) was 5.4 L, volume of distribution at steady-state (Vdss) was 222.6 L, metabolic clearance (Cl(1)) was 0.84 L/min and elimination half-life (t(1/2)y) was 389 minutes. Patients′ age, gender and PaCO(2) correlated significantly with the pharmacokinetic parameters. The Vdss, volume of slowly equilibrating compartment (V(3)) and t(1/2) y increased, and rapid distribution clearance (Cl(2)) decreased with increasing patient age. Male patients had larger values of Vdss, volume of rapidly equilibrating compartment (V(2)) and V(3) than female patients. The Vdss and V(3) increased with higher PaCO(2) values. There were no significant correlations between the pharmacokinetic variables and body weight, height, lean body mass, plasma albumin, sufentanil dose, duration of surgery, pH or base excess of blood (BE-B).

Conclusions The pharmacokinetics of sufentanil TCI in Chinese patients can be optimally described by a three-compartment model. The pharmacokinetic analysis technique may affect the pharmacokinetic parameters and correlations. Chin Med J 2009;122(17):1979-1984

语种: 英语
所属项目编号: YZZ07-7-11 ; BL09-6-14
项目资助者: Seed Foundation of Peking University Third Hospital ; Anesthesiology Scientific Research Foundation
WOS记录号: WOS:000269783700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61226
Appears in Collections:北京大学第一临床医学院_麻醉科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Anesthesiol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhao Yan,Duan Jing-li,Wu Xin-min,et al. Two-stage analysis of pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese patients[J]. CHINESE MEDICAL JOURNAL,2009,122(17):1979-1984.
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