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Two-stage analysis of pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese patients
Zhao Yan2; Duan Jing-li3; Wu Xin-min1; Jiang Jian-yu2; Lu Wei4; Zhang Li-ping2; Wang Jun2; Meng Xiu-li2; Xu Chuan-ya2; Jia Dong-lin2; Liu Wei3; Sheng Xiao-yan3
关键词anesthesia sufentanil pharmacokinetics target-controlled infusion two-stage analysis
刊名CHINESE MEDICAL JOURNAL
2009-09-05
DOI10.3760/cmaj.issn.0366-6999.2009.17.004
122期:17页:1979-1984
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]SURGICAL-PATIENTS ; OBESE PATIENTS ; HUMAN PLASMA ; SURGERY ; PROPOFOL ; ANESTHESIA ; ADULTS ; TRIAL ; TIME
英文摘要

Background Sufentanil is a suitable choice for target-controlled infusion (TCI) because of its shorter context-sensitive half-time. The current study was to estimate the pharmacokinetics of sufentanil TCI in Chinese patients using the two-stage analysis.

Methods Twelve adult patients with American Society of Anesthesiologists (ASA) physical status I or II undergoing elective surgery under general anesthesia were included. Anesthesia was induced with propofol, rocuronium and sufentanil administered by TCI lasting for 30 minutes, with target effect-site concentration of sufentanil 4 or 6 ng/ml. Frequent arterial blood samples (1.5 ml) were taken during and up to 24 hours after sufentanil TCI. Before the end of surgery, another arterial blood sample (1.0 ml) was drawn for the blood-gas analysis. Plasma sufentanil concentrations were determined by liquid chromatography-tandem mass spectrometry (limit of quantitation was 5 pg/ml). The data were analyzed with the two-stage approach, linear regression and correlation analysis.

Results The pharmacokinetics of sufentanil TCI were adequately described by a three-compartment model. The variables were derived as follows: the volume of central compartment (V(1)) was 5.4 L, volume of distribution at steady-state (Vdss) was 222.6 L, metabolic clearance (Cl(1)) was 0.84 L/min and elimination half-life (t(1/2)y) was 389 minutes. Patients′ age, gender and PaCO(2) correlated significantly with the pharmacokinetic parameters. The Vdss, volume of slowly equilibrating compartment (V(3)) and t(1/2) y increased, and rapid distribution clearance (Cl(2)) decreased with increasing patient age. Male patients had larger values of Vdss, volume of rapidly equilibrating compartment (V(2)) and V(3) than female patients. The Vdss and V(3) increased with higher PaCO(2) values. There were no significant correlations between the pharmacokinetic variables and body weight, height, lean body mass, plasma albumin, sufentanil dose, duration of surgery, pH or base excess of blood (BE-B).

Conclusions The pharmacokinetics of sufentanil TCI in Chinese patients can be optimally described by a three-compartment model. The pharmacokinetic analysis technique may affect the pharmacokinetic parameters and correlations. Chin Med J 2009;122(17):1979-1984

语种英语
WOS记录号WOS:000269783700004
项目编号YZZ07-7-11 ; BL09-6-14
资助机构Seed Foundation of Peking University Third Hospital ; Anesthesiology Scientific Research Foundation
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61226
专题北京大学第一临床医学院_麻醉科
北京大学药学院_药剂学系
北京大学第三临床医学院_麻醉科
北京大学第三临床医学院_疼痛科
北京大学第三临床医学院_药剂科
作者单位1.Peking Univ, Hosp 3, Dept Pharm, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Anesthesiol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao Yan,Duan Jing-li,Wu Xin-min,et al. Two-stage analysis of pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese patients[J]. CHINESE MEDICAL JOURNAL,2009,122(17):1979-1984.
APA Zhao Yan.,Duan Jing-li.,Wu Xin-min.,Jiang Jian-yu.,Lu Wei.,...&Sheng Xiao-yan.(2009).Two-stage analysis of pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese patients.CHINESE MEDICAL JOURNAL,122(17),1979-1984.
MLA Zhao Yan,et al."Two-stage analysis of pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese patients".CHINESE MEDICAL JOURNAL 122.17(2009):1979-1984.
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