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学科主题: 基础医学
题名:
Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)
作者: Wei, Lan1; Sun, Shen1; Zhang, Jing1; Zhu, Hong1; Xu, Yun1; Ma, Qiang1; McNutt, Michael A.2; Korteweg, Christine2; Gu, Jiang2,3
关键词: SARS ; adenohypophysis ; endocrine cell ; immunohistochemistry
刊名: BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
发表日期: 2010-08-01
DOI: 10.1139/O10-022
卷: 88, 期:4, 页:723-730
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: HORMONAL PARAMETERS ; GROWTH-HORMONE ; VARICOCELES ; STRESS ; MEN ; HYPERPROLACTINEMIA ; CORONAVIRUS ; SECRETION ; PATHOLOGY
英文摘要:

It is known that severe acute respiratory syndrome (SARS), a severe infectious illness, which caused an epidemic in Asia in 2003. has extensive and complex effects on human organ systems It has been reported that the scrum levels of prolactin (PR L) follicle stimulating hormone (FSH). and luteinizing hormone (LH) of SARS patients are siginficantly higher than those of control groups. while estradiol (El). pregnancy hormone (P), and thyroid stimulating hormone (TS H) arc considerably lower than those of normal controls This phenomenon suggests that the adenohypophyseal endocrine cells in SARS patients may be damaged However. up to now there has been no direct histological in on the endocrine cells of patients′ pituitary Here we investigated the endocrine cells in the adenohypophysis obtained from autopsies of 5 SARS patients The mimunolustochemistry and quantitative image results showed that compared with control cases, both the number of positive cells and the slanting intensity of immunoreactivity for growth hormone. TS H, and adrenocorticotrophic hormone in these cells were remarkably decreased. while that ol PRL. FSH. and LH were significantly increased in all SA RS cases studied These findings indicated that alterations occurred in the patients′ adenohypophyscal endoerme cells, and these changes were consistent with the seruM levels of relevant endocrine hormones reported previously It appears that changes in these enclocime cells and their hormones arc affected by the severity of this new infectious disease

语种: 英语
WOS记录号: WOS:000280731100021
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61228
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Dept Pathol, Shantou, Peoples R China
2.Beijing Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China
3.Beijing Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Wei, Lan,Sun, Shen,Zhang, Jing,et al. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)[J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,2010,88(4):723-730.
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