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学科主题基础医学
Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)
Wei, Lan1; Sun, Shen1; Zhang, Jing1; Zhu, Hong1; Xu, Yun1; Ma, Qiang1; McNutt, Michael A.2; Korteweg, Christine2; Gu, Jiang2,3
关键词SARS adenohypophysis endocrine cell immunohistochemistry
刊名BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
2010-08-01
DOI10.1139/O10-022
88期:4页:723-730
收录类别SCI ; ISTP
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]HORMONAL PARAMETERS ; GROWTH-HORMONE ; VARICOCELES ; STRESS ; MEN ; HYPERPROLACTINEMIA ; CORONAVIRUS ; SECRETION ; PATHOLOGY
英文摘要

It is known that severe acute respiratory syndrome (SARS), a severe infectious illness, which caused an epidemic in Asia in 2003. has extensive and complex effects on human organ systems It has been reported that the scrum levels of prolactin (PR L) follicle stimulating hormone (FSH). and luteinizing hormone (LH) of SARS patients are siginficantly higher than those of control groups. while estradiol (El). pregnancy hormone (P), and thyroid stimulating hormone (TS H) arc considerably lower than those of normal controls This phenomenon suggests that the adenohypophyseal endocrine cells in SARS patients may be damaged However. up to now there has been no direct histological in on the endocrine cells of patients′ pituitary Here we investigated the endocrine cells in the adenohypophysis obtained from autopsies of 5 SARS patients The mimunolustochemistry and quantitative image results showed that compared with control cases, both the number of positive cells and the slanting intensity of immunoreactivity for growth hormone. TS H, and adrenocorticotrophic hormone in these cells were remarkably decreased. while that ol PRL. FSH. and LH were significantly increased in all SA RS cases studied These findings indicated that alterations occurred in the patients′ adenohypophyscal endoerme cells, and these changes were consistent with the seruM levels of relevant endocrine hormones reported previously It appears that changes in these enclocime cells and their hormones arc affected by the severity of this new infectious disease

语种英语
WOS记录号WOS:000280731100021
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61228
专题北京大学基础医学院_病理学系
作者单位1.Shantou Univ, Coll Med, Dept Pathol, Shantou, Peoples R China
2.Beijing Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China
3.Beijing Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wei, Lan,Sun, Shen,Zhang, Jing,et al. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)[J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,2010,88(4):723-730.
APA Wei, Lan.,Sun, Shen.,Zhang, Jing.,Zhu, Hong.,Xu, Yun.,...&Gu, Jiang.(2010).Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS).BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE,88(4),723-730.
MLA Wei, Lan,et al."Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)".BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 88.4(2010):723-730.
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