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学科主题: 口腔医学
题名:
Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception
作者: Li, Kai1,2; Fu, Kai-Yuan1,2; Light, Alan R.3; Mao, Jianren4
关键词: Microglia ; OX-42 ; MHC class I ; p38 MAPK ; Minocycline ; Formalin
刊名: JOURNAL OF NEUROIMMUNOLOGY
发表日期: 2010-04-15
DOI: 10.1016/j.jneuroim.2010.02.003
卷: 221, 期:1-2, 页:25-31
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Neurosciences
研究领域[WOS]: Immunology ; Neurosciences & Neurology
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; PERIPHERAL-NERVE INJURY ; P38 MAPK ; NEUROPATHIC PAIN ; CYTOKINE EXPRESSION ; INFLAMMATORY PAIN ; SENSORY NEURONS ; DORSAL-HORN ; RAT ; INJECTION
英文摘要:

In the present study, intraperitoneal administration of minocycline attenuated enhancing nociceptive behaviors in those rats receiving dual formalin injections (5% formalin followed at 7 days later by 1% formalin). The minocycline treatment did not prevent the increase in OX-42 and MHC class I labeling and morphological changes, but significantly attenuated upregulation of phospho-p38 in activated microglia. These results suggest that the later days of microglial activation with upregulated immune markers in the spinal cord contributes to enhancing long-term pain response by a pathway of p38 activation in microglia. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30973337 ; DE18214 ; DE18538
项目资助者: Program for New Century Excellent Talents in University ; National Natural Science Foundation ; US PHS RO1
WOS记录号: WOS:000278653100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61229
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Ctr TMD & Orofacial Pain, Beijing 100081, Peoples R China
2.Hosp Stomatol, Beijing 100081, Peoples R China
3.Univ Utah, Dept Anesthesiol, Salt Lake City, UT 84132 USA
4.Harvard Univ, Sch Med, Massachusetts Gen Hosp,WACC 324, MGH Ctr Translat Pain Res,Dept Anesthesia & Crit, Boston, MA 02114 USA

Recommended Citation:
Li, Kai,Fu, Kai-Yuan,Light, Alan R.,et al. Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception[J]. JOURNAL OF NEUROIMMUNOLOGY,2010,221(1-2):25-31.
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