IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception
Li, Kai1,2; Fu, Kai-Yuan1,2; Light, Alan R.3; Mao, Jianren4
关键词Microglia OX-42 MHC class I p38 MAPK Minocycline Formalin
刊名JOURNAL OF NEUROIMMUNOLOGY
2010-04-15
DOI10.1016/j.jneuroim.2010.02.003
221期:1-2页:25-31
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Neurosciences
研究领域[WOS]Immunology ; Neurosciences & Neurology
关键词[WOS]ACTIVATED PROTEIN-KINASE ; PERIPHERAL-NERVE INJURY ; P38 MAPK ; NEUROPATHIC PAIN ; CYTOKINE EXPRESSION ; INFLAMMATORY PAIN ; SENSORY NEURONS ; DORSAL-HORN ; RAT ; INJECTION
英文摘要

In the present study, intraperitoneal administration of minocycline attenuated enhancing nociceptive behaviors in those rats receiving dual formalin injections (5% formalin followed at 7 days later by 1% formalin). The minocycline treatment did not prevent the increase in OX-42 and MHC class I labeling and morphological changes, but significantly attenuated upregulation of phospho-p38 in activated microglia. These results suggest that the later days of microglial activation with upregulated immune markers in the spinal cord contributes to enhancing long-term pain response by a pathway of p38 activation in microglia. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000278653100004
项目编号30973337 ; DE18214 ; DE18538
资助机构Program for New Century Excellent Talents in University ; National Natural Science Foundation ; US PHS RO1
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61229
专题北京大学口腔医学院
北京大学公共卫生学院_公共卫生学院
北京大学口腔医学院_口腔放射科
作者单位1.Peking Univ, Sch Stomatol, Ctr TMD & Orofacial Pain, Beijing 100081, Peoples R China
2.Hosp Stomatol, Beijing 100081, Peoples R China
3.Univ Utah, Dept Anesthesiol, Salt Lake City, UT 84132 USA
4.Harvard Univ, Sch Med, Massachusetts Gen Hosp,WACC 324, MGH Ctr Translat Pain Res,Dept Anesthesia & Crit, Boston, MA 02114 USA
推荐引用方式
GB/T 7714
Li, Kai,Fu, Kai-Yuan,Light, Alan R.,et al. Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception[J]. JOURNAL OF NEUROIMMUNOLOGY,2010,221(1-2):25-31.
APA Li, Kai,Fu, Kai-Yuan,Light, Alan R.,&Mao, Jianren.(2010).Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception.JOURNAL OF NEUROIMMUNOLOGY,221(1-2),25-31.
MLA Li, Kai,et al."Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception".JOURNAL OF NEUROIMMUNOLOGY 221.1-2(2010):25-31.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Kai]的文章
[Fu, Kai-Yuan]的文章
[Light, Alan R.]的文章
百度学术
百度学术中相似的文章
[Li, Kai]的文章
[Fu, Kai-Yuan]的文章
[Light, Alan R.]的文章
必应学术
必应学术中相似的文章
[Li, Kai]的文章
[Fu, Kai-Yuan]的文章
[Light, Alan R.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。