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Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males
Jin, Ying; Chen, Dafang; Hu, Yonghua; Guo, Song; Sun, Hongqiang; Lu, Aili; Zhang, Xiaoyan; Li, Lingsong
关键词gene monoamine oxidase nicotine dependence polymorphism smoking
刊名INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
2006-10-01
DOI10.1017/S1461145705006218
9期:5页:557-564
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]DOPAMINE METABOLIC ENZYMES ; NICOTINE DEPENDENCE ; FUNCTIONAL POLYMORPHISM ; TOBACCO CONSUMPTION ; RISK-FACTORS ; A GENE ; SMOKERS ; PERSONALITY ; INHIBITION ; INITIATION
英文摘要

Monoamine oxidase (MAO) is a critical metabolic enzyme of dopamine, which is a key neurotransmitter of the mesolimbic reward pathway in the human brain. Consequently, the gene encoding MAO is all important candidate gene in the genetics of smoking behaviour. We investigated the association between MAOA polymorphisms (a VNTR polymorphism and an EcoRV polymorphism) and smoking status. A community-based cross-sectional study was conducted with 203 current smoking subjects and 168 non-current smoking subjects in Beijing, China. Genotyping for these polymorphisms was performed using PCR and restriction fragment length polymorphism. Multiple logistic regression models were used to analyse the association of MAOA gene polymorphisms with smoking status. We found that individuals with the 1460T/O genotype had a significantly increased the risk of smoking compared to those with 1460C/O. The adjusted odds ratios (aORs) were 3.2 (95% Cl 2.0-5.2) in current vs. non-current smokers group, 1.7 (95% CI 1.1-2.8) in ever vs. never smokers group, 2.5 (95% Cl 1.4-4.3) in current vs. never smokers group, and 5.3 (95% CI 2.5-11.2) in current vs. former smokers group respectively. We also found that individuals with the 3-repeat genotype of the VNTR polymorphism had a significantly increased risk of smoking significantly compared to those with the 4-repeat genotype. The aORs were 2.0 (95% Cl 1.0-4.1) in the current vs. former smokers group, and 1.9 (95% CI 1.0-3.6) in the nicotine dependent vs. non-nicotine dependent group respectively. Moreover, MAOA gene haplotypes were associated significantly with nicotine dependence in every group. In conclusion, there is an important association between MAOA polymorphisms and smoking status, suggesting a possible role of MAOA gene variants in nicotine dependence.

语种英语
WOS记录号WOS:000242062600007
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61235
专题北京大学公共卫生学院
作者单位1.Peking Univ, Stem Cell Res Ctr, Beijing, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Beijing 100083, Peoples R China
3.Capital Univ Med Sci, Beijing Anding Hosp, Natl Drug Dependence Treatment Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Jin, Ying,Chen, Dafang,Hu, Yonghua,et al. Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2006,9(5):557-564.
APA Jin, Ying.,Chen, Dafang.,Hu, Yonghua.,Guo, Song.,Sun, Hongqiang.,...&Li, Lingsong.(2006).Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,9(5),557-564.
MLA Jin, Ying,et al."Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 9.5(2006):557-564.
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